Results 1 to 10 of about 1,046 (126)

Azole Resistance and cyp51A Mutation of Aspergillus fumigatus in a Tertiary Referral Hospital in Taiwan

Journal of Fungi, 2022
Azole resistance in Aspergillus fumigatus has increasingly been reported worldwide. Its major mechanism of resistance is mediated by mutations in cyp51A. The objective of this study was to test the antifungal susceptibilities of A.
Tsun-Hao Hsu, Po-Yen Huang, Yun-Chen Fan, Pei-Lun Sun   +3 more
doaj   +2 more sources

A Novel Zn2-Cys6 Transcription Factor AtrR Plays a Key Role in an Azole Resistance Mechanism of Aspergillus fumigatus by Co-regulating cyp51A and cdr1B Expressions. [PDF]

PLoS Pathogens, 2017
Successful treatment of aspergillosis caused by Aspergillus fumigatus is threatened by an increasing incidence of drug resistance. This situation is further complicated by the finding that strains resistant to azoles, the major antifungal drugs for ...
Daisuke Hagiwara, Daisuke Miura, Kiminori Shimizu, Sanjoy Paul, Ayumi Ohba, Tohru Gonoi, Akira Watanabe, Katsuhiko Kamei, Takahiro Shintani, W Scott Moye-Rowley, Susumu Kawamoto, Katsuya Gomi   +11 more
doaj   +2 more sources

Differential Functions of Individual Transcription Factor Binding Sites in the Tandem Repeats Found in Clinically Relevant cyp51A Promoters in Aspergillus fumigatus

mBio, 2022
Aspergillus fumigatus is the major filamentous fungal pathogen in humans. The gold standard treatment of A. fumigatus is based on azole drug use, but the appearance of azole-resistant isolates is increasing at an alarming rate.
Sanjoy Paul, Paul E. Verweij, Willem J. G. Melchers, W. Scott Moye-Rowley   +3 more
doaj   +1 more source

Azole Resistance-Associated Regulatory Motifs within the Promoter of cyp51A in Aspergillus fumigatus

Microbiology Spectrum, 2022
Aspergillus fumigatus is one of the deadliest fungal species, causing hundreds of thousands of deaths each year. Because azoles provide the preferred first-line option for treatment of aspergillosis, the increase in rates of resistance and the poor ...
Alexander Kühbacher, Mandy Peiffer, Peter Hortschansky, Petra Merschak, Michael J. Bromley, Hubertus Haas, Axel A. Brakhage, Fabio Gsaller   +7 more
doaj   +1 more source

An appraisal of antifungal impacts of nano-liposome containing voriconazole on voriconazole-resistant Aspergillus flavus isolates as a groundbreaking drug delivery system [PDF]

Nanomedicine Research Journal, 2020
Background: This study is an attempt to investigate the effect of nano-liposome containing voriconazole on voriconazole-resistant A. flavus strains on the one hand, and to consider the expression of cyp51A and MDR1genes, regarded as important genes ...
Parviz Hassanpour, Hamed Hamishehkar, Behzad Baradaran, Maryam Mohammadi, Navid Shomali, Adel Spotin, Teimour Hazratian, Sanam Nami   +7 more
doaj   +1 more source

Uncovering New Mutations Conferring Azole Resistance in the Aspergillus fumigatus cyp51A Gene

Frontiers in Microbiology, 2020
The opportunistic pathogen Aspergillus fumigatus has developed worldwide resistance to azoles largely through mutations in cytochromeP450 enzyme Cyp51.
Peiying Chen, Musang Liu, Musang Liu, Qiuqiong Zeng, Zheng Zhang, Weida Liu, Weida Liu, Hong Sang, Ling Lu   +8 more
doaj   +1 more source

Screening for M220 mutation in azole-resistant Aspergillus fumigatus isolates from clinical and environmental specimens in Cuba

Italian Journal of Mycology, 2021
Aspergillosis is a fungal disease caused by different Aspergillus species and have high morbidity/mortality rates. Aspergillus fumigatus is the main aetiological agent related to most of Aspergillus infections.
Javier Luis San Juan Galán, Carlos Manuel Fernández Andreu, Gerardo Félix Martínez Machín, Mayda Rosa Perurena Lancha, María Teresa Illnait Zaragozí, Rosario Esperanza Velar Martínez   +5 more
doaj   +1 more source

The Utilization of RNA Silencing Technology to Mitigate the Voriconazole Resistance of Aspergillus Flavus; Lipofectamine-Based Delivery [PDF]

Advanced Pharmaceutical Bulletin, 2017
Purpose: Introducing the effect of RNAi in fungi to downregulate essential genes has made it a powerful tool to investigate gene function, with potential strategies for novel disease treatments. Thus, this study is an endeavor to delve into the silencing
Sanam Nami, Behzad Baradaran, Behzad Mansoori, Parivash Kordbacheh, Sasan Rezaie, Mehraban Falahati, Leila Mohamed Khosroshahi, Mahin Safara, Farideh Zaini   +8 more
doaj   +1 more source

hapE and hmg1 Mutations Are Drivers of cyp51A-Independent Pan-Triazole Resistance in an Aspergillus fumigatus Clinical Isolate

Microbiology Spectrum, 2023
Aspergillus fumigatus is a ubiquitous environmental mold that can cause severe disease in immunocompromised patients and chronic disease in individuals with underlying lung conditions. Triazoles are the most widely used class of antifungal drugs to treat
Ana C. O. Souza, Wenbo Ge, Nathan P. Wiederhold, Jeffrey M. Rybak, Jarrod R. Fortwendel, P. David Rogers   +5 more
doaj   +1 more source

Are Point Mutations in HMG-CoA Reductases (Hmg1 and Hmg2) a Step towards Azole Resistance in Aspergillus fumigatus?

Molecules, 2021
Invasive aspergillosis, mainly caused by Aspergillus fumigatus, can lead to severe clinical outcomes in immunocompromised individuals. Antifungal treatment, based on the use of azoles, is crucial to increase survival rates.
Irene Gonzalez-Jimenez, Jose Lucio, Alejandra Roldan, Laura Alcazar-Fuoli, Emilia Mellado   +4 more
doaj   +1 more source