Results 1 to 10 of about 1,715 (126)

Genotype–Phenotype Relationships in Azole-Resistant Aspergillus: Two Sides of the Same Coin [PDF]

Journal of Fungi
Aspergillus fumigatus is a leading cause of invasive fungal disease in humans and is classified as a critical priority threat by the World Health Organization.
Merlijn H. I. van Haren, Willem J. G. Melchers, Jianhua Zhang, Sarah Dellière, Christine C. Bii, Felicia A. Stanford, Michael Voetz, P. Lewis White, Paul S. Dyer, Suzan D. Pas, Paul E. Verweij, Jochem B. Buil   +11 more
doaj   +2 more sources

Understanding multi-azole resistance in Aspergillus fumigatus: the impact of non-cyp51A mutation and efflux pump overexpression [PDF]

Frontiers in Fungal Biology
IntroductionAzole resistance in Aspergillus fumigatus is an emerging global concern, significantly limiting treatment options for aspergillosis. The present study aimed to investigate azole resistance mechanisms, focusing on non-cyp51A mutations and ...
Pooja Sen, Lokesh Kumar, Jata Shankar, Pooja Vijayaraghavan   +3 more
doaj   +2 more sources

Environmental Circulation of Aspergillus fumigatus With Reduced Susceptibility to Agricultural Triazole in Brazil: Clonal Dissemination of Potentially Resistant Genotypes. [PDF]

Mycoses
ABSTRACT Background Aspergillus fumigatus resistance to triazole antifungals poses an increasing global health concern. Moreover, the cross‐resistance between azole antifungal agents used in clinical settings and those applied in agriculture has become an important emerging issue.
de Barros Rodrigues DK, Leeuwerik M, Brankovics B, Fava WS, Venturini J, Meyer W, Arai T, Majima H, Watanabe A, de Souza Carvalho Melhem M.   +9 more
europepmc   +2 more sources

Uncovering New Mutations Conferring Azole Resistance in the Aspergillus fumigatus cyp51A Gene

Frontiers in Microbiology, 2020
The opportunistic pathogen Aspergillus fumigatus has developed worldwide resistance to azoles largely through mutations in cytochromeP450 enzyme Cyp51.
Hong Sang, Zheng Zhang, Ling Lu
exaly   +3 more sources

Monitoring fungicide resistance frequencies - a case study of barley net blotch. [PDF]

Pest Manag Sci
Droplet digital PCR revealed the frequency of alleles associated with decreased sensitivity to demethylation inhibitor (DMI) and succinate dehydrogenase inhibitor (SDHI) fungicides in Pyrenophora teres from barley net blotch in Western Australia. The findings highlight field‐level allele dynamics and emerging risks to fungicide efficacy.
Knight NL, Adhikari KC, Mair WJ, Dodhia K, Zulak KG, Lopez-Ruiz FJ.   +5 more
europepmc   +2 more sources

A 23 bp cyp51A Promoter Deletion Associated With Voriconazole Resistance in Clinical and Environmental Isolates of Neocosmospora keratoplastica

Frontiers in Microbiology, 2020
In the fungal pathogen Aspergillus fumigatus, resistance to azole antifungals is often linked to mutations in CYP51A, a gene that encodes the azole antifungal drug target lanosterol 14α-demethylase.
Jasper E James, Latiffah Zakaria, Erwin Lamping   +2 more
exaly   +3 more sources

The First Isolation of Multiple Antifungal-Drug-Resistant Trichophyton Rubrum in China and the Novel Resistance Mechanism. [PDF]

Mycoses
ABSTRACT Objectives This study reports the first isolation of a multidrug‐resistant Trichophyton rubrum strain in China, characterizing its drug resistance profile and mechanisms. Methods The isolate was identified by internal transcribed spacer (ITS) sequencing and phylogenetic analysis.
Song G, Xie W, Kong X, Zheng H, Tsui CKM, Xiaodong She, Liu W, Li X, Liang G.   +8 more
europepmc   +2 more sources

In Vitro Activity of Nitroxoline (5-Nitro-8-Hydroxyquinoline) Against Aspergillus Species. [PDF]

Mycoses
ABSTRACT Background Nitroxoline is an old antibiotic currently approved for the treatment of uncomplicated urinary tract infections. Its mode of action is based on the chelation of bivalent cations, such as zinc. Objectives As zinc plays a central role in the metabolism of Aspergillus spp., we performed antifungal susceptibility testing against ...
Hoffmann A, Cornely OA, Vonhoegen J, Sprute R, Reinhold I, Walther G, Fuchs F, Simon M.   +7 more
europepmc   +2 more sources

Appearance of Environment-Linked Azole Resistance in the Aspergillus fumigatus Complex in New Zealand. [PDF]

Mycoses
ABSTRACT Background Until 2020, azole resistance in Aspergillus fumigatus complex isolates in New Zealand was due to cyp51A hot spot mutations. This report details the appearance of environment‐linked tandem repeat (TR)‐related azole resistance genotypes since 2021. Methods Isolates were tested by broth micro‐dilution.
Morris AJ, McKinney WP, Roberts SA, Sithamparanathan S, Chaudhry Z, Fisher MC.   +5 more
europepmc   +2 more sources

Direct Molecular Diagnosis of Aspergillosis and CYP51A Profiling from Respiratory Samples of French Patients

Frontiers in Microbiology, 2016
Background: Microbiological diagnosis of aspergillosis and triazole resistance is limited by poor culture yield. To better estimate this shortcoming, we compared culture and molecular detection of A.
David Perlin, Yanan Zhao, Marie-Pierre Brenier-Pinchart   +2 more
exaly   +3 more sources