Results 1 to 10 of about 34,473 (219)

Therapeutic drug monitoring and safety evaluation of voriconazole in the treatment of pulmonary fungal diseases

Therapeutic Advances in Drug Safety, 2022
Aims: The gene polymorphism of voriconazole metabolism–related liver enzyme is notable in East Asia population. It casts a significant influence on the rational use of voriconazole.
Kunlu Shen, Yueyan Ni, Yajie Lu
exaly   +2 more sources

Prediction of the Impact of CYP2C19 Polymorphism on Drug-Drug Interaction between Voriconazole and Tacrolimus Using Physiologically-Based Pharmacokinetic Modelling [PDF]

Brazilian Journal of Pharmaceutical Sciences, 2023
Voriconazole increases tacrolimus blood concentration significantly when coadministrated. The recommendation of reducing tacrolimus to 1/3 in voriconazole package insert seems not to be satisfactory in clinical practice.
Zhi-Ping Jin, Miao Yan, Si-Ze Li, Bao-Qing Wang, Qing Xu, Wei Wu, Xiao-Yu Li, Qian-Zhou Lv, Xiao-Qiang Xiang   +8 more
doaj   +1 more source

High-Performance Liquid Chromatography for Ultra-Simple Determination of Plasma Voriconazole Concentration

Journal of Fungi, 2022
Voriconazole is an antifungal drug used to treat invasive aspergillosis. Voriconazole exhibits nonlinear behavior and considerable individual variability in its pharmacokinetic profile.
Takeo Yasu, Yuka Nomura, Yoshito Gando, Yasuhiko Matsumoto, Takashi Sugita, Nobuharu Kosugi, Masayuki Kobayashi   +6 more
doaj   +1 more source

Concomitant Treatment with Voriconazole and Flucloxacillin: A Combination to Avoid

Antibiotics, 2021
Background: Voriconazole is an antifungal drug used as one of the first-line treatments for invasive aspergillosis. This drug is extensively metabolized, predominantly via cytochrome P450 enzymes.
Ruth Van Daele, Joost Wauters, Pieter De Cock, Franky Buyle, John Leys, Pieter Van Brantegem, Matthias Gijsen, Pieter Annaert, Yves Debaveye, Katrien Lagrou, Willy E. Peetermans, Roger J. Brüggemann, Isabel Spriet   +12 more
doaj   +1 more source

Voriconazole Induced Hallucinations and Visual Disturbances in a Female Child: A Case Report and Literature Review

Frontiers in Pediatrics, 2021
Voriconazole is a second-generation azole widely used for the prevention and treatment of fungal infection in leukemia patients. We report a case of 9-year-old girl with T-cell acute lymphoblastic leukemia who developed hallucinations and visual ...
Rujiang Zheng, Yu Li, Chuyi Guo, Yuxin Pei, Zhiyong Ke, Libin Huang   +5 more
doaj   +1 more source

An appraisal of antifungal impacts of nano-liposome containing voriconazole on voriconazole-resistant Aspergillus flavus isolates as a groundbreaking drug delivery system [PDF]

Nanomedicine Research Journal, 2020
Background: This study is an attempt to investigate the effect of nano-liposome containing voriconazole on voriconazole-resistant A. flavus strains on the one hand, and to consider the expression of cyp51A and MDR1genes, regarded as important genes ...
Parviz Hassanpour, Hamed Hamishehkar, Behzad Baradaran, Maryam Mohammadi, Navid Shomali, Adel Spotin, Teimour Hazratian, Sanam Nami   +7 more
doaj   +1 more source

Association between voriconazole exposure and Sequential Organ Failure Assessment (SOFA) score in critically ill patients.

PLoS ONE, 2021
Therapeutic drug monitoring (TDM) is essential for voriconazole to ensure optimal drug exposure, mainly in critically ill patients for whom voriconazole demonstrated a large variability.
Anne-Lise Bienvenu, Pierre Pradat, Alexandra Plesa, Vincent Leclerc, Vincent Piriou, Jean-Luc Fellahi, Laurent Argaud, Thomas Rimmelé, Jean Menotti, Frédéric Aubrun, Jean-Christophe Richard, Marie-Claude Gagnieu, François Parant, Christian Chidiac, Gilles Leboucher, Michel Tod, Sylvain Goutelle   +16 more
doaj   +1 more source

Relationship between voriconazole trough concentration and liver injury in elderly patients with lung invasive aspergillosis

Di-san junyi daxue xuebao, 2020
Objective To investigate the relationship between voriconazole trough concentration and liver injury in elderly patients with lung invasive aspergillosis.
CHENG Lin, WENG Bangbi, XIANG Rongfeng, SUN Fengjun   +3 more
doaj   +1 more source

Impact of Inflammation on Voriconazole Exposure in Critically ill Patients Affected by Probable COVID-19-Associated Pulmonary Aspergillosis

Antibiotics, 2023
(1) Background: To explore the impact of the degree of inflammation on voriconazole exposure in critically ill patients affected by COVID-associated pulmonary aspergillosis (CAPA); (2) Methods: Critically ill patients receiving TDM-guided voriconazole ...
Milo Gatti, Giacomo Fornaro, Zeno Pasquini, Andrea Zanoni, Michele Bartoletti, Pierluigi Viale, Federico Pea   +6 more
doaj   +1 more source

Comparative study of posaconazole and voriconazole for primary antifungal prophylaxis in patients with pediatric acute leukemia

Scientific Reports, 2023
Posaconazole and voriconazole are commonly used for preventing invasive fungal disease (IFD), but few studies compared posaconazole with voriconazole for primary antifungal prophylaxis (PAP) in pediatric acute leukemia.
Songji Tu, Kunlong Zhang, Ningling Wang, Jinhua Chu, Linhai Yang, Zhiwei Xie   +5 more
doaj   +1 more source