Results 21 to 30 of about 25,647 (169)

The pharmacokinetics of voriconazole [PDF]

British Journal of Clinical Pharmacology, 2003
Voriconazole (Vfend® Pfizer Global Research and Development, Sandwich, Kent, UK) is a broad-spectrum antifungal triazole that is structurally related to fluconazole. As with all triazole antifungal agents, voriconazole works principally by inhibition of cytochrome P450 14-α-demethylase (P450 14DM) [1, 2].
openaire   +2 more sources

Relationship between voriconazole trough concentration and liver injury in elderly patients with lung invasive aspergillosis

Di-san junyi daxue xuebao, 2020
Objective To investigate the relationship between voriconazole trough concentration and liver injury in elderly patients with lung invasive aspergillosis.
CHENG Lin, WENG Bangbi, XIANG Rongfeng, SUN Fengjun   +3 more
doaj   +1 more source

Comparative study of posaconazole and voriconazole for primary antifungal prophylaxis in patients with pediatric acute leukemia

Scientific Reports, 2023
Posaconazole and voriconazole are commonly used for preventing invasive fungal disease (IFD), but few studies compared posaconazole with voriconazole for primary antifungal prophylaxis (PAP) in pediatric acute leukemia.
Songji Tu, Kunlong Zhang, Ningling Wang, Jinhua Chu, Linhai Yang, Zhiwei Xie   +5 more
doaj   +1 more source

Impact of Inflammation on Voriconazole Exposure in Critically ill Patients Affected by Probable COVID-19-Associated Pulmonary Aspergillosis

Antibiotics, 2023
(1) Background: To explore the impact of the degree of inflammation on voriconazole exposure in critically ill patients affected by COVID-associated pulmonary aspergillosis (CAPA); (2) Methods: Critically ill patients receiving TDM-guided voriconazole ...
Milo Gatti, Giacomo Fornaro, Zeno Pasquini, Andrea Zanoni, Michele Bartoletti, Pierluigi Viale, Federico Pea   +6 more
doaj   +1 more source

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

Sustained-release voriconazole-thermogel for subconjunctival injection in horses: ocular toxicity and in-vivo studies

BMC Veterinary Research, 2020
Background Keratomycosis is a relatively common, sight threatening condition in horses, where treatment is often prolonged and costly. Subconjunctival (SCo) injections offer less resistance to drug diffusion than the topical route, resulting in better ...
Mariano Mora-Pereira, Eva M. Abarca, Sue Duran, William Ravis, Richard J. McMullen, Britta M. Fischer, Yann-Huei Phillip Lee, Anne A. Wooldridge   +7 more
doaj   +1 more source

Therapeutic Drug Monitoring of Sputum Voriconazole in Pulmonary Aspergillosis

Pharmaceutics, 2022
Voriconazole is one of the most used antifungal azoles against pulmonary aspergillosis. Therapeutic drug monitoring (TDM) of the voriconazole concentration in plasma is recommended in clinical practice guidelines to prevent treatment failure and toxicity.
Sacha Sarfati, Julien Wils, Timothée Lambert, Céline Mory, Laurent Imbert, Gilles Gargala, Hélène Morisse-Pradier, Fabien Lamoureux   +7 more
doaj   +1 more source

Predictors of Adverse Events and Determinants of the Voriconazole Trough Concentration in Kidney Transplantation Recipients

Clinical and Translational Science, 2021
Voriconazole is the mainstay for the treatment of invasive fungal infections in patients who underwent a kidney transplant. Variant CYP2C19 alleles, hepatic function, and concomitant medications are directly involved in the metabolism of voriconazole ...
Yi‐Chang Zhao, Xiao‐Bin Lin, Bi‐Kui Zhang, Yi‐wen Xiao, Ping Xu, Feng Wang, Da‐Xiong Xiang, Xu‐Biao Xie, Feng‐Hua Peng, Miao Yan   +9 more
doaj   +1 more source

Evaluation of the interaction of intravenous and oral voriconazole with oral cyclosporine in iranian HSCT patients

Journal of Research in Pharmacy Practice, 2017
Objective: Voriconazole as a triazole antifungal agent is widely used for prophylaxis or treatment of fungal infections in allogeneic hematopoietic stem cell transplantation (HSCT).
Hamidreza Taghvaye Masoumi, Molouk Hadjibabaie, Mohammad Vaezi, Ardeshir Ghavamzadeh   +3 more
doaj   +1 more source

Combined Effect of CYP2C19 Genetic Polymorphisms and C-Reactive Protein on Voriconazole Exposure and Dosing in Immunocompromised Children

Frontiers in Pediatrics, 2022
BackgroundPediatric patients have significant interindividual variability in voriconazole exposure. The aim of the study was to identify factors associated with voriconazole concentrations and dose requirements to achieve therapeutic concentrations in ...
Juan Chen, Ying Wu, Yuelin He, Xiaoqin Feng, Yuqiong Ren, Shiting Liu   +5 more
doaj   +1 more source