Results 21 to 30 of about 34,473 (219)
The pharmacokinetics of voriconazole [PDF]
British Journal of Clinical Pharmacology, 2003 Voriconazole (Vfend® Pfizer Global Research and Development, Sandwich, Kent, UK) is a broad-spectrum antifungal triazole that is structurally related to fluconazole. As with all triazole antifungal agents, voriconazole works principally by inhibition of cytochrome P450 14-α-demethylase (P450 14DM) [1, 2].
openaire +2 more sources
BMC Veterinary Research, 2020 Background Keratomycosis is a relatively common, sight threatening condition in horses, where treatment is often prolonged and costly. Subconjunctival (SCo) injections offer less resistance to drug diffusion than the topical route, resulting in better ...
Mariano Mora-Pereira +7 more
doaj +1 more source
Therapeutic Drug Monitoring of Sputum Voriconazole in Pulmonary Aspergillosis
Pharmaceutics, 2022 Voriconazole is one of the most used antifungal azoles against pulmonary aspergillosis. Therapeutic drug monitoring (TDM) of the voriconazole concentration in plasma is recommended in clinical practice guidelines to prevent treatment failure and toxicity.
Sacha Sarfati +7 more
doaj +1 more source
Clinically relevant bidirectional drug-drug interaction between midostaurin and voriconazole. [PDF]
, 2023 Midostaurin is often prescribed with azole antifungals in patients with leukemia, either for aspergillosis prophylaxis or treatment. Midostaurin is extensively metabolized by cytochrome (CYP) 3A4.
Lamoth, F +23 more
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Voriconazole-induced periostitis post lung transplantation
, 2022 Voriconazole is a broad-spectrum triazole antifungal used to treatinvasive fungal infections. It is commonly used prophylactically in immunocompromized patient cohorts, including transplant recipients.
Orla M. Murray (12596119) +3 more
core +1 more source
Journal of Research in Pharmacy Practice, 2017 Objective: Voriconazole as a triazole antifungal agent is widely used for prophylaxis or treatment of fungal infections in allogeneic hematopoietic stem cell transplantation (HSCT).
Hamidreza Taghvaye Masoumi +3 more
doaj +1 more source
Clinical and Translational Science, 2021 Voriconazole is the mainstay for the treatment of invasive fungal infections in patients who underwent a kidney transplant. Variant CYP2C19 alleles, hepatic function, and concomitant medications are directly involved in the metabolism of voriconazole ...
Yi‐Chang Zhao +9 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Aims: We aimed to assess the impact of extracorporeal membrane oxygenation (ECMO) on voriconazole exposure.Methods: Adult critically ill patients with or without ECMO support receiving intravenous voriconazole therapy were included in this retrospective ...
Qinghua Ye +11 more
doaj +1 more source
Case Reports in Medicine, 2010 Voriconazole is a treatment for severe fungal infections. Prolonged voriconazole therapy may induce skin reactions, with 1% of severe photosensitivity accidents. Recently the imputability of voriconazole in skin carcinogenesis has been suggested.
C. Morice +6 more
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Frontiers in Pediatrics, 2022 BackgroundPediatric patients have significant interindividual variability in voriconazole exposure. The aim of the study was to identify factors associated with voriconazole concentrations and dose requirements to achieve therapeutic concentrations in ...
Juan Chen +5 more
doaj +1 more source