A Retrospective, Comparative Cohort Analysis of the Utilization of Voriconazole-Containing Regimens Versus Itraconazole in the Treatment of Blastomycosis [PDF]
Journal of FungiItraconazole is the recommended first-line antifungal agent in blastomycosis treatment. However, pharmacokinetic limitations and adverse drug events may necessitate the use of alternative antifungal agents.
Caitlin C. Schanz +8 more
doaj +2 more sources
Prediction of the Impact of CYP2C19 Polymorphism on Drug-Drug Interaction between Voriconazole and Tacrolimus Using Physiologically-Based Pharmacokinetic Modelling [PDF]
Brazilian Journal of Pharmaceutical Sciences, 2023 Voriconazole increases tacrolimus blood concentration significantly when coadministrated. The recommendation of reducing tacrolimus to 1/3 in voriconazole package insert seems not to be satisfactory in clinical practice.
Zhi-Ping Jin +8 more
doaj +1 more source
Voriconazole-Induced acute interstitial pulmonary edema with angioedema: A case report [PDF]
BMC Pulmonary MedicineBackground Voriconazole is a first-line antifungal agent for invasive fungal infections. Reports of voriconazole-induced interstitial pulmonary edema are exceedingly rare.
Yuzhen Jin +4 more
doaj +2 more sources
Journal of Fungi, 2022 Voriconazole is an antifungal drug used to treat invasive aspergillosis. Voriconazole exhibits nonlinear behavior and considerable individual variability in its pharmacokinetic profile.
Takeo Yasu +6 more
doaj +1 more source
Frontiers in Pediatrics, 2021 Voriconazole is a second-generation azole widely used for the prevention and treatment of fungal infection in leukemia patients. We report a case of 9-year-old girl with T-cell acute lymphoblastic leukemia who developed hallucinations and visual ...
Rujiang Zheng +5 more
doaj +1 more source
Concomitant Treatment with Voriconazole and Flucloxacillin: A Combination to Avoid
Antibiotics, 2021 Background: Voriconazole is an antifungal drug used as one of the first-line treatments for invasive aspergillosis. This drug is extensively metabolized, predominantly via cytochrome P450 enzymes.
Ruth Van Daele +12 more
doaj +1 more source
The Global Antifungal Susceptibility Epidemiology of Trichophyton indotineae Indicating Voriconazole as an Alternative Therapy for Recalcitrant Dermatophytosis. [PDF]
MycosesABSTRACT Background The emergence of Trichophyton indotineae as a multidrug‐resistant dermatophyte has challenged conventional therapeutic approaches for dermatophytosis, leading to a significant therapeutic dilemma. The absence of formal epidemiological cutoff values (ECVs) under the Clinical and Laboratory Standards Institute (CLSI) framework has led
Song G +5 more
europepmc +2 more sources
An appraisal of antifungal impacts of nano-liposome containing voriconazole on voriconazole-resistant Aspergillus flavus isolates as a groundbreaking drug delivery system [PDF]
Nanomedicine Research Journal, 2020 Background: This study is an attempt to investigate the effect of nano-liposome containing voriconazole on voriconazole-resistant A. flavus strains on the one hand, and to consider the expression of cyp51A and MDR1genes, regarded as important genes ...
Parviz Hassanpour +7 more
doaj +1 more source
Therapeutic Advances in Drug Safety, 2022 Aims: The gene polymorphism of voriconazole metabolism–related liver enzyme is notable in East Asia population. It casts a significant influence on the rational use of voriconazole.
Kunlu Shen +7 more
doaj +1 more source
PLoS ONE, 2021 Therapeutic drug monitoring (TDM) is essential for voriconazole to ensure optimal drug exposure, mainly in critically ill patients for whom voriconazole demonstrated a large variability.
Anne-Lise Bienvenu +16 more
doaj +1 more source