Results 31 to 40 of about 1,046 (126)

Study of Azole - Resistant and Cyp51a Gene in Aspergillus Fumigatus

, 2018
AIM: The main goal of the present study was to find azole-resistant and molecular analysis of cyp51A gene in Aspergillus fumigatus.MATERIALS AND METHODS: Fifty-eight A.
Majid Zarrin, Sama Faramarzi
core   +1 more source

Data_Sheet_1_A 23 bp cyp51A Promoter Deletion Associated With Voriconazole Resistance in Clinical and Environmental Isolates of Neocosmospora keratoplastica.docx

, 2020
In the fungal pathogen Aspergillus fumigatus, resistance to azole antifungals is often linked to mutations in CYP51A, a gene that encodes the azole antifungal drug target lanosterol 14α-demethylase.
Richard David Cannon (8638647), Latiffah Zakaria (8638644), Trudy Jane Milne (8638638), Erwin Lamping (1337808), Jasper Elvin James (8638632), Mohd Fuat Abd Razak (8638641), Jacinta Santhanam (8638635)   +6 more
core   +1 more source

Role of Aspergillus lentulus 14-α Sterol Demethylase (Cyp51A) in Azole Drug Susceptibility

, 2011
Recent studies have demonstrated that some morphologically atypical Aspergillus fumigatus strains are different species belonging to the section Fumigati . Aspergillus lentulus , one
Manuel Cuenca-Estrella, Juan L. Rodriguez-Tudela, Laura Alcazar-Fuoli, Emilia Mellado   +3 more
core   +1 more source

Performance of Molecular Approaches for Aspergillus Detection and Azole Resistance Surveillance in Cystic Fibrosis

Frontiers in Microbiology, 2018
Aspergillus fumigatus triazole resistance is an emerging concern for treating chronically infected/colonized patients. This study sought to evaluate the performance of PCR assays to detect Aspergillus fungi together with azole resistance in sputum ...
Hélène Guegan, Sylviane Chevrier, Chantal Belleguic, Eric Deneuville, Florence Robert-Gangneux, Florence Robert-Gangneux, Jean-Pierre Gangneux, Jean-Pierre Gangneux   +7 more
doaj   +1 more source

Phylogenetic and Structural Analysis of Miconazole Susceptibility in Malassezia pachydermatis Isolates From Dogs With Otitis Externa

Veterinary Dermatology, Volume 37, Issue 5, Page 620-629, October 2026.
Background: An increased number of dogs with unresolved yeast otitis externa (OE) after miconazole treatment was observed at a tertiary practice. Hypothesis/Objectives: To evaluate miconazole susceptibility in Malassezia pachydermatis isolates from canine OE.
Cole M. Belcher, Clarissa P. Souza, Elyas McGuire, Chien‐Che Hung, Joel D. A. Tyndall, Lois L. Hoyer   +5 more
wiley   +1 more source

An efficient gene targeting system using Δku80 and functional analysis of Cyp51A in Trichophyton rubrum

AMB Express
Trichophyton rubrum is one of the most frequently isolated fungi in patients with dermatophytosis. Despite its clinical significance, the molecular mechanisms of drug resistance and pathogenicity of T.
Masaki Ishii, Tsuyoshi Yamada, Shinya Ohata   +2 more
doaj   +1 more source

Genotype–Phenotype Relationships in Azole-Resistant Aspergillus: Two Sides of the Same Coin

Journal of Fungi
Aspergillus fumigatus is a leading cause of invasive fungal disease in humans and is classified as a critical priority threat by the World Health Organization.
Merlijn H. I. van Haren, Willem J. G. Melchers, Jianhua Zhang, Sarah Dellière, Christine C. Bii, Felicia A. Stanford, Michael Voetz, P. Lewis White, Paul S. Dyer, Suzan D. Pas, Paul E. Verweij, Jochem B. Buil   +11 more
doaj   +1 more source

Fungal Antimicrobial Resistance: Mechanisms, Drivers, and Global Clinical Burden

ChemFoodChem, Volume 2, Issue 3, September 2026.
ABSTRACT Fungal antimicrobial resistance (AMR) is a growing concern for world health caused by an increase in multidrug‐resistant infections, an increase in environmental reservoirs, and the ineffectiveness of current antifungal treatments. Fungal infections continue to be largely excluded from AMR initiatives while causing over 1.6 million deaths ...
Bikash Baral
wiley   +1 more source

Azole resistance profile of amino acid changes in Aspergillus fumigatus CYP51A based on protein homology modeling. [PDF]

, 2010
Contains fulltext : 88470.pdf (Publisher’s version ) (Open Access)Molecular studies have shown that the majority of azole resistance in Aspergillus fumigatus is associated with amino acid substitutions in the cyp51A gene.
Snelders, Eveline, Snelders, E., Melchers, W.J.G., Schaftenaar, Gijs, Verweij, Paul E., Karawajczyk, A., Melchers, Willem J.G., Schaftenaar, G., Karawajczyk, Anna, Verweij, P.E.   +9 more
core   +2 more sources

Afu-Emi1 Contributes to Stress Adaptation and Voriconazole Susceptibility in Aspergillus fumigatus

Microbiology Spectrum, 2023
Invasive aspergillosis (IA) is the second most common invasive fungal disease and is associated with high mortality rates. Aspergillus fumigatus is the predominant causal agent of this life-threatening infection.
Jufang Tan, Heng Zhang, Yi Sun, Lujuan Gao   +3 more
doaj   +1 more source