Results 31 to 40 of about 1,765 (165)
Italian Journal of Mycology, 2021 Aspergillosis is a fungal disease caused by different Aspergillus species and have high morbidity/mortality rates. Aspergillus fumigatus is the main aetiological agent related to most of Aspergillus infections.
Javier Luis San Juan Galán +5 more
doaj +1 more source
Evidence for the Role of CYP51A and Xenobiotic Detoxification in Differential Sensitivity to Azole Fungicides in Boxwood Blight Pathogens [PDF]
International Journal of Molecular Sciences, 2021 Boxwood blight, a fungal disease of ornamental plants (Buxus spp.), is caused by two sister species, Calonectria pseudonaviculata (Cps) and C. henricotiae (Che). Compared to Cps, Che is documented to display reduced sensitivity to fungicides, including the azole class of antifungals, which block synthesis of a key fungal membrane component, ergosterol.
Stefanos Stravoravdis +4 more
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Interrogation of Related Clinical Pan-Azole-Resistant Aspergillus fumigatus Strains: G138C, Y431C, and G434C Single Nucleotide Polymorphisms incyp51A, Upregulation ofcyp51A, and Integration and Activation of TransposonAtf1in thecyp51APromoter [PDF]
Antimicrobial Agents and Chemotherapy, 2011 ABSTRACTMultipleAspergillus fumigatusisolates from a patient with two aspergillomas complicating chronic pulmonary aspergillosis were pan-azole resistant. Microsatellite typing was identical for all isolates despite major phenotypic and some growth rate differences. Three differentcyp51Amutations were found (G138C, Y431C, and G434C), of which the first
Ahmed M. Albarrag +6 more
openaire +1 more source
Molecules, 2021 Invasive aspergillosis, mainly caused by Aspergillus fumigatus, can lead to severe clinical outcomes in immunocompromised individuals. Antifungal treatment, based on the use of azoles, is crucial to increase survival rates.
Irene Gonzalez-Jimenez +4 more
doaj +1 more source
The cdr1B efflux transporter is associated with non-cyp51a-mediated itraconazole resistance in Aspergillus fumigatus [PDF]
Journal of Antimicrobial Chemotherapy, 2013 Recent increases in triazole resistance in Aspergillus fumigatus have been attributed primarily to target site (cyp51A) mutations. A recent survey of resistant isolates in Manchester showed that >50% of resistant isolates had no mutation in cyp51A or its promoter. We investigated the mechanisms of resistance in clinical azole-resistant isolates without
Fraczek, Marcin G +8 more
openaire +3 more sources
Mycobiology, 2020 We investigated the antifungal susceptibilities and the cyp51 mutant strains among Aspergillus fumigatus clinical isolates obtained from 10 university hospitals in Korea. Of the 84 isolates examined, two itraconazole-resistant isolates were found with no
Eun Jeong Won +7 more
doaj +1 more source
In Vivo Emergence of Aspergillus terreus with Reduced Azole Susceptibility and a Cyp51a M217I Alteration [PDF]
The Journal of Infectious Diseases, 2012 Azole resistance in Aspergillus terreus isolates was explored. Twenty related (MB) and 6 unrelated A. terreus isolates were included. CYP51A sequencing and RAPD genotyping was performed. Five MB isolates were itraconazole susceptible, whereas the minimum inhibitory concentrations (MICs) for 15 MB isolates were elevated (1-2 mg/L).
Maiken C, Arendrup +6 more
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Current Issues in Molecular Biology, 2022 Multiple demethylation-inhibiting (DMI) fungicides are used to control pecan scab, caused by Venturia effusa. To compare the efficacy of various DMI fungicides on V.
Logan C. Moore +4 more
doaj +1 more source
Role of Aspergillus lentulus 14-α Sterol Demethylase (Cyp51A) in Azole Drug Susceptibility [PDF]
Antimicrobial Agents and Chemotherapy, 2011 ABSTRACT Recent studies have demonstrated that some morphologically atypical Aspergillus fumigatus strains are different species belonging to the section Fumigati . Aspergillus lentulus , one of these sibling species, is increasingly reported in patients ...
Emilia, Mellado +3 more
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Azole resistance and cyp51A mutation screening in Aspergillus fumigatus in Mexico
Journal of Antimicrobial Chemotherapy, 2019 AbstractBackgroundFungicide exposure in the environment has driven the emergence of azole-resistant Aspergillus fumigatus worldwide. A screening test allows identification of resistant isolates.ObjectivesWe screened clinical samples for azole-resistant Aspergillus through azole-containing agar plates and identified mutations in the cyp51A gene of A ...
Maria F, Gonzalez-Lara +8 more
openaire +2 more sources