Differentiation of Aspergillus flavus from Aspergillus oryzae Targeting the cyp51A Gene [PDF]
Pathogens, 2021 Aspergillus flavus is one of the most important agents of invasive and non-invasive aspergillosis, especially in tropical and subtropical regions of the world, including Iran. Aspergillus oryzae is closely related to A. flavus, and it is known for its economic importance in traditional fermentation industries. Reports of infection due to A.
Sanaz Nargesi +6 more
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An Improved Model of the Aspergillus fumigatus CYP51A Protein [PDF]
Antimicrobial Agents and Chemotherapy, 2011 ABSTRACT Azole resistance is an increasing clinical problem for Aspergillus fumigatus , with the majority of published resistance arising from mutations in the azole target gene CYP51A. Previous structural studies of this protein have suffered from a nonorthologous, low-homology template for homology ...
Fraczek, M. G. +2 more
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Deciphering Aspergillus fumigatus cyp51A-mediated triazole resistance by pyrosequencing of respiratory specimens [PDF]
Journal of Antimicrobial Chemotherapy, 2020 Abstract Background Infections caused by triazole drug-resistant Aspergillus fumigatus are an increasing problem. The sensitivity of standard culture is poor, abrogating susceptibility testing. Early detection of resistance can improve patient outcomes, yet tools for this purpose are limited.
Lilyann Novak-Frazer +7 more
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Study of Azole - Resistant and Cyp51a Gene in Aspergillus Fumigatus [PDF]
Open Access Macedonian Journal of Medical Sciences, 2018 AIM: The main goal of the present study was to find azole-resistant and molecular analysis of cyp51A gene in Aspergillus fumigatus.MATERIALS AND METHODS: Fifty-eight A. fumigatus strains including environmental, clinical and reference isolates were assessed in this investigation.
Zarrin, Majid, Faramarzi, Sama
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A Novel Combination of CYP51A Mutations Confers Pan-Azole Resistance in Aspergillus fumigatus [PDF]
Antimicrobial Agents and Chemotherapy, 2020 The treatment of invasive and chronic aspergillosis involves triazole drugs. Its intensive use has resulted in the selection of resistant isolates, and at present, azole resistance in Aspergillus fumigatus is considered an emerging threat to public health worldwide.
Daiana Macedo +5 more
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An appraisal of antifungal impacts of nano-liposome containing voriconazole on voriconazole-resistant Aspergillus flavus isolates as a groundbreaking drug delivery system [PDF]
Nanomedicine Research Journal, 2020 Background: This study is an attempt to investigate the effect of nano-liposome containing voriconazole on voriconazole-resistant A. flavus strains on the one hand, and to consider the expression of cyp51A and MDR1genes, regarded as important genes ...
Parviz Hassanpour +7 more
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cyp51A-based mechanism of azole resistance inAspergillus fumigatus: Illustration by a new 3D Structural Model ofAspergillus fumigatusCYP51A protein [PDF]
Medical Mycology, 2016 Mutations of CYP51A protein (Cytochrome P450 14-α Sterol demethylase) play a central role in the azole resistance of Aspergillus fumigatus The available structural models of CYP51A protein ofA. fumigatus are built based on that of Homo sapiens and that of Mycobacterium tuberculosis, of which the amino acid homology is only 38% and 29% compared with ...
Musang, Liu +6 more
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A Novel Zn2-Cys6 Transcription Factor AtrR Plays a Key Role in an Azole Resistance Mechanism of Aspergillus fumigatus by Co-regulating cyp51A and cdr1B Expressions. [PDF]
PLoS Pathogens, 2017 Successful treatment of aspergillosis caused by Aspergillus fumigatus is threatened by an increasing incidence of drug resistance. This situation is further complicated by the finding that strains resistant to azoles, the major antifungal drugs for ...
Daisuke Hagiwara +11 more
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The Utilization of RNA Silencing Technology to Mitigate the Voriconazole Resistance of Aspergillus Flavus; Lipofectamine-Based Delivery [PDF]
Advanced Pharmaceutical Bulletin, 2017 Purpose: Introducing the effect of RNAi in fungi to downregulate essential genes has made it a powerful tool to investigate gene function, with potential strategies for novel disease treatments. Thus, this study is an endeavor to delve into the silencing
Sanam Nami +8 more
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Microbiology Spectrum, 2023 Aspergillus fumigatus is a ubiquitous environmental mold that can cause severe disease in immunocompromised patients and chronic disease in individuals with underlying lung conditions. Triazoles are the most widely used class of antifungal drugs to treat
Ana C. O. Souza +5 more
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