Results 21 to 30 of about 1,046 (126)

Data_Sheet_1_Uncovering New Mutations Conferring Azole Resistance in the Aspergillus fumigatus cyp51A Gene.pdf

, 2020
The opportunistic pathogen Aspergillus fumigatus has developed worldwide resistance to azoles largely through mutations in cytochromeP450 enzyme Cyp51.
Weida Liu (848554), Qiuqiong Zeng (6811145), Musang Liu (8337030), Zheng Zhang (88857), Hong Sang (490404), Peiying Chen (6811148), Ling Lu (53325)   +6 more
core   +1 more source

A Cyp51B Mutation Contributes to Azole Resistance in Aspergillus fumigatus

Journal of Fungi, 2020
The emergence and spread of Aspergillus fumigatus azole resistance has been acknowledged worldwide. The main problem of azole resistance is the limited therapeutic options for patients suffering aspergillosis. Azole resistance mechanisms have been mostly
Irene Gonzalez-Jimenez, Jose Lucio, Jorge Amich, Isabel Cuesta, Rafael Sanchez Arroyo, Laura Alcazar-Fuoli, Emilia Mellado   +6 more
doaj   +1 more source

Biochemical Identification of a Nuclear Coactivator Protein Required for AtrR-Dependent Gene Regulation in Aspergillus fumigatus

mSphere, 2022
Azole drugs represent the primary means of treating infections associated with the filamentous fungal pathogen Aspergillus fumigatus. A central player in azole resistance is the Zn2Cys6 zinc cluster-containing transcription factor AtrR.
Sanjoy Paul, Shivani Ror, W. Hayes McDonald, W. Scott Moye-Rowley   +3 more
doaj   +1 more source

In Vitro Activity of Isavuconazole and Other Mould-Active Azoles against Aspergillus fumigatus with and without CYP51 Alterations

Journal of Fungi, 2023
Azole resistance in Aspergillus fumigatus (AFM) is mainly associated with mutations in CYP51A and its promoter region or its homologue CYP51B. We evaluated the in vitro activity of isavuconazole, itraconazole, posaconazole, and voriconazole against 660 ...
Michael A. Pfaller, Cecilia G. Carvalhaes, Lalitagauri M. Deshpande, Paul R. Rhomberg, Mariana Castanheira   +4 more
doaj   +1 more source

Genome-Wide Association Analysis for Triazole Resistance in Aspergillus fumigatus

Pathogens, 2021
Aspergillus fumigatus is a ubiquitous fungus and the main agent of aspergillosis, a common fungal infection in the immunocompromised population. Triazoles such as itraconazole and voriconazole are the common first-line drugs for treating aspergillosis ...
Yuying Fan, Yue Wang, Gregory A. Korfanty, Meagan Archer, Jianping Xu   +4 more
doaj   +1 more source

An improved model of the Aspergillus fumigatus CYP51A protein

, 2011
Azole resistance is an increasing clinical problem for Aspergillus fumigatus, with the majority of published resistance arising from mutations in the azole target gene CYP51A.
Bromley, M.; id_orcid, Bowyer, P., M. G. Fraczek, M. Bromley, P. Bowyer, Fraczek, M. G.   +5 more
core   +1 more source

Targeted gene disruption of the 14-alpha sterol demethylase (cyp51A) in Aspergillus fumigatus and its role in azole drug susceptibility [PDF]

, 2005
The role of Aspergillus fumigatus 14alpha-sterol demethylase (Cyp51A) in azole drug susceptibility was assessed. Targeted disruption of cyp51A in azole-susceptible and -resistant strains decreased MICs from 2- to 40-fold.
Alcazar-Fuoli, Laura, Cuenca-Estrella, Manuel, Buitrago, Maria Jose, Rodriguez-Tudela, Juan Luis, Garcia-Effron, Guillermo, Mellado, Emilia   +5 more
core   +1 more source

AtrR Is an Essential Determinant of Azole Resistance in Aspergillus fumigatus

mBio, 2019
Aspergillosis associated with azole-resistant Aspergillus fumigatus has a mortality rate that can approach 90% in certain patient populations. The best-understood avenue for azole resistance involves changes in the cyp51A gene that encodes the target of ...
Sanjoy Paul, Mark Stamnes, Grace Heredge Thomas, Hong Liu, Daisuke Hagiwara, Katsuya Gomi, Scott G. Filler, W. Scott Moye-Rowley   +7 more
doaj   +1 more source

Hmg1 Gene Mutation Prevalence in Triazole-Resistant Aspergillus fumigatus Clinical Isolates

Journal of Fungi, 2020
Recently, mutations in the 3-hydroxy-3-methylglutaryl-coenzyme-A-reductase-encoding gene (hmg1), a gene involved in ergosterol production, were associated with triazole-resistance in Aspergillus fumigatus.
Agustin Resendiz-Sharpe, Margriet W.J. Hokken, Toine Mercier, Rita Merckx, Kamiel Verhagen, Lisa Dewitte, Willem J.G. Melchers, Paul E. Verweij, Johan Maertens, Katrien Lagrou   +9 more
doaj   +1 more source

First Report of Azole-Resistant Aspergillus fumigatus with TR₄₆/Y121F/T289A Mutations in Kuwait and an Update on Their Occurrence in the Middle East

Journal of Fungi, 2023
Pulmonary aspergillosis is a common fungal infection with several clinical manifestations including invasive, allergic and chronic chest diseases.
Mohammad Asadzadeh, Khaled Alobaid, Suhail Ahmad, Sara Mazloum   +3 more
doaj   +1 more source