Results 41 to 50 of about 1,765 (165)
Journal of Fungi, 2023 Azole resistance in Aspergillus fumigatus (AFM) is mainly associated with mutations in CYP51A and its promoter region or its homologue CYP51B. We evaluated the in vitro activity of isavuconazole, itraconazole, posaconazole, and voriconazole against 660 ...
Michael A. Pfaller +4 more
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mSphere, 2022 Azole drugs represent the primary means of treating infections associated with the filamentous fungal pathogen Aspergillus fumigatus. A central player in azole resistance is the Zn2Cys6 zinc cluster-containing transcription factor AtrR.
Sanjoy Paul +3 more
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A Cyp51B Mutation Contributes to Azole Resistance in Aspergillus fumigatus
Journal of Fungi, 2020 The emergence and spread of Aspergillus fumigatus azole resistance has been acknowledged worldwide. The main problem of azole resistance is the limited therapeutic options for patients suffering aspergillosis. Azole resistance mechanisms have been mostly
Irene Gonzalez-Jimenez +6 more
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Genome-Wide Association Analysis for Triazole Resistance in Aspergillus fumigatus
Pathogens, 2021 Aspergillus fumigatus is a ubiquitous fungus and the main agent of aspergillosis, a common fungal infection in the immunocompromised population. Triazoles such as itraconazole and voriconazole are the common first-line drugs for treating aspergillosis ...
Yuying Fan +4 more
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AtrR Is an Essential Determinant of Azole Resistance in
mBio, 2019 Aspergillosis associated with azole-resistant Aspergillus fumigatus has a mortality rate that can approach 90% in certain patient populations. The best-understood avenue for azole resistance involves changes in the cyp51A gene that encodes the target of ...
Sanjoy Paul +7 more
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Hmg1 Gene Mutation Prevalence in Triazole-Resistant Aspergillus fumigatus Clinical Isolates
Journal of Fungi, 2020 Recently, mutations in the 3-hydroxy-3-methylglutaryl-coenzyme-A-reductase-encoding gene (hmg1), a gene involved in ergosterol production, were associated with triazole-resistance in Aspergillus fumigatus.
Agustin Resendiz-Sharpe +9 more
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Journal of Fungi, 2023 Pulmonary aspergillosis is a common fungal infection with several clinical manifestations including invasive, allergic and chronic chest diseases.
Mohammad Asadzadeh +3 more
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CRISPR/Cas9 Genome Editing To Demonstrate the Contribution of Cyp51A Gly138Ser to Azole Resistance in Aspergillus fumigatus [PDF]
Antimicrobial Agents and Chemotherapy, 2018 A pan-azole-resistant Aspergillus fumigatus strain with the cyp51A mutations Gly138Ser and Asn248Lys was isolated from a patient receiving long-term voriconazole treatment. PCR fragments containing cyp51A with the
Takashi Umeyama +11 more
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Microbiology Resource Announcements, 2023 ABSTRACT Azoles are major antifungals in agriculture and medicine. However, the surge of intrinsic azole resistance is critical for public health. Here, we present the complete long-read sequencing of three azole-resistant Penicillium rubens from food crops.
Jeff Gauthier +7 more
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Detection of Azole Drug Resistance of the Aspergillus Species Cyp51a Gene by PCR
Journal of Medical Sciences and Health, 2019 Background: Allergic bronchopulmonary aspergillosis (ABPA) is a hypersensitivity pulmonary disease occurring in individuals with asthma or cystic fibrosis. In these patients, it is characterized by transient pulmonary infiltrates, reversible airway obstruction, eosinophilia, and evidence of hypersensitivity to the Aspergillus fumigatus. The aim of this
Raksha, Gurjeet Singh, A D Urhekar
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