Results 41 to 50 of about 1,046 (126)

A Multifactorial Azole Response in Clinically Relevant Fusarium Species Complexes

Mycoses, Volume 69, Issue 9, September 2026.
ABSTRACT Background Fusarium spp. are clinically relevant filamentous fungi with intrinsically low susceptibility to multiple antifungal agents, particularly azoles, and are included in the World Health Organization fungal priority pathogens list.
Patrícia Helena Grizante Barião, Ludmilla Tonani, Adriana Rodrigues Alves, Otávio Guilherme Gonçalves de Almeida, Cledir Santos, Marcia Regina von Zeska Kress   +5 more
wiley   +1 more source

Understanding multi-azole resistance in Aspergillus fumigatus: the impact of non-cyp51A mutation and efflux pump overexpression

Frontiers in Fungal Biology
IntroductionAzole resistance in Aspergillus fumigatus is an emerging global concern, significantly limiting treatment options for aspergillosis. The present study aimed to investigate azole resistance mechanisms, focusing on non-cyp51A mutations and ...
Pooja Sen, Lokesh Kumar, Jata Shankar, Pooja Vijayaraghavan   +3 more
doaj   +1 more source

Hidden Mould in the Air: A Practical Narrative Mini‐Review of Invasive Mould Infection Prevention for High‐Risk Patients and Clinicians

Mycoses, Volume 69, Issue 9, September 2026.
ABSTRACT Airborne mould spores, including those of the Aspergillus species, are ubiquitous both indoors and outdoors. While they are generally harmless, inhaled spores can cause severe infections, particularly invasive pulmonary aspergillosis, in patients with impaired immune defences.
Angelika Bauer, Cornelia Lass‐Flörl, Stephan Steixner, Oliver Cornely, Ilana Reinhold, Laura Walti, on behalf of International Society for Human and Animal Mycology (ISHAM) Working Group for Patient Representation and Advocacy in Invasive Fungal Infections   +6 more
wiley   +1 more source

Structural basis of HapE P88L -linked antifungal triazole resistance in Aspergillus fumigatus

Life Science Alliance, 2020
The mutation P88L in subunit HapE of the CCAAT transcription factor causes resistance of Aspergillus fumigatus to azole drugs due to altered binding, bending, and transcription of target promoters.
Peter Hortschansky, Matthias Misslinger, Jasmin Mörl, Fabio Gsaller, Michael J Bromley, Axel A Brakhage, Michael Groll, Hubertus Haas, Eva M Huber   +8 more
doaj   +1 more source

Stomatal Morphology, Leaf Nutrients and Molecular Adaptations Are Associated With Scald Resistance in Barley

Physiologia Plantarum, Volume 178, Issue 5, September/October 2026.
ABSTRACT Scald, caused by Rhynchosporium secalis, can reduce grain yield by up to 40% in susceptible cultivars. To investigate physiological and molecular responses associated with scald resistance in barley, we compared a susceptible cultivar, Atlantis, with a resistant cultivar, Yangsimai 3, under uninoculated control and R.
Usman Ijaz, Muhammad Atif Azeem, Sergey Shabala, Meixue Zhou, Chenchen Zhao   +4 more
wiley   +1 more source

Genomic perspective of triazole resistance in clinical and environmental Aspergillus fumigatus isolates without cyp51A mutations

, 2019
Aspergillus fumigatus is the most common etiologic agent of primarily all clinical manifestations of aspergillosis. A steady increase in the number of azole resistant A.
Singh, Ashutosh, Radhakrishna Pillai, M., Nelson-Sathi, Shijulal, Sharma, Cheshta, Chowdhary, Anuradha   +4 more
core   +1 more source

A point mutation in the 14alpha-sterol demethylase gene cyp51A contributes to itraconazole resistance in Aspergillus fumigatus [PDF]

, 2003
Erratum in: Antimicrob Agents Chemother. 2004 Mar;48(3):1071.The genes encoding 14alpha-sterol demethylases (cyp51A and cyp51B) were analyzed in 12 itraconazole (ITC)-resistant and three ITC-susceptible clinical isolates of Aspergillus fumigatus. Six ITC-
Cuenca-Estrella, Manuel, Rodriguez-Tudela, Juan Luis, Diaz-Guerra, Teresa M., Mellado, Emilia   +3 more
core   +1 more source

Emerging Antifungal Resistance in Tropical Mycoses: A Genomic and Clinical Perspective From Endemic Zones

Journal of the Royal Society of New Zealand, Volume 56, Issue 4, August 2026.
Antifungal resistance in tropical mycoses is an increasingly important component of the global antimicrobial resistance crisis, particularly in endemic regions where diagnostic capacity, therapeutic options, and surveillance systems are limited. This review synthesizes clinical, environmental, and genomic evidence on resistance in major endemic and ...
Meral Miraloglu
wiley   +1 more source

Comparison of Two Molecular Assays for Detection and Characterization of Aspergillus fumigatus Triazole Resistance and Cyp51A Mutations in Clinical Isolates and Primary Clinical Samples of Immunocompromised Patients

Frontiers in Microbiology, 2018
In hematological patients, the incidence of invasive aspergillosis (IA) caused by azole resistant Aspergillus fumigatus (ARAf) is rising. As the diagnosis of IA is rarely based on positive culture in this group of patients, molecular detection of ...
Patricia Postina, Julian Skladny, Tobias Boch, Oliver A. Cornely, Oliver A. Cornely, Axel Hamprecht, Peter-Michael Rath, Jörg Steinmann, Oliver Bader, Thomas Miethke, Anne Dietz, Natalia Merker, Wolf-Karsten Hofmann, Dieter Buchheidt, Birgit Spiess   +14 more
doaj   +1 more source

Antifungal Potential of Cumin Spice Seeds, Cuminum cyminum, Against Aspergillus fumigatus: Mechanistic Insights Into Ergosterol, Melanin, and Biofilm Inhibition

Food Frontiers, Volume 7, Issue 4, July 2026.
Antifungal effects and underlying mechanism of the action of the supercritical fluid extracted from the cumin (Cuminum cyminum) seeds and its volatile phyto‐constituents against pathogenic Aspergillus fumigatus. ABSTRACT Spices are aromatic culinary ingredients used worldwide for enhancing food flavors, folklore therapy, and their antiseptic ...
Acharya Balkrishna, Lovely Gupta, Rani Singh, Yash Varshney, Rishabh Dev, Pardeep Nain, Savita Lochab, Anurag Varshney   +7 more
wiley   +1 more source