Results 61 to 70 of about 1,046 (126)

Complementation of a Saccharomyces cerevisiae ERG11/CYP51 (Sterol 14alpha-Demethylase) Doxycycline-Regulated Mutant and Screening of the Azole Sensitivity of Aspergillus fumigatus Isoenzymes CYP51A and CYP51B

, 2010
Aspergillus fumigatus sterol 14α-demethylase isoenzymes CYP51A and CYP51B were heterologously expressed in a Saccharomyces cerevisiae mutant (YUG37- erg11 ), wherein native ERG11/CYP51 ...
Andrew Warrilow, Steven Kelly, Andrew G. S. Warrilow, Nicola J. Rolley, Steven L. Kelly, Diane E. Kelly, Claire Hull, Diane Kelly, Josie Parker, Claire M. Martel, Josie E. Parker   +10 more
core   +1 more source

Environmental Circulation of Aspergillus fumigatus With Reduced Susceptibility to Agricultural Triazole in Brazil: Clonal Dissemination of Potentially Resistant Genotypes

Mycoses, Volume 69, Issue 5, May 2026.
ABSTRACT Background Aspergillus fumigatus resistance to triazole antifungals poses an increasing global health concern. Moreover, the cross‐resistance between azole antifungal agents used in clinical settings and those applied in agriculture has become an important emerging issue.
Dality Keffelen de Barros Rodrigues, Manuel Leeuwerik, Balázs Brankovics, Wellington Santos Fava, James Venturini, Wieland Meyer, Teppei Arai, Hidetaka Majima, Akira Watanabe, Marcia de Souza Carvalho Melhem   +9 more
wiley   +1 more source

Evidence for the Role of CYP51A and Xenobiotic Detoxification in Differential Sensitivity to Azole Fungicides in Boxwood Blight Pathogens

, 2021
Boxwood blight, a fungal disease of ornamental plants (Buxus spp.), is caused by two sister species, Calonectria pseudonaviculata (Cps) and C. henricotiae (Che).
LeBlanc, Nicholas R, Crouch, JoAnne, Jonathan P. Hulvey, Stravoravdis, Stefanos, Robert E. Marra, Hulvey, Jonathan P, Stefanos Stravoravdis, Marra, Robert E, Jo Anne Crouch, Nicholas R. LeBlanc   +9 more
core   +1 more source

Evaluation of Two Cyclonic Bioaerosol Samplers for Hospital Air Monitoring in a Calibrated Test Chamber Integrating Aerodynamics and Biological Endpoints

Indoor Air, Volume 2026, Issue 1, 2026.
Indoor air quality (IAQ) monitoring in hospital settings is critical to limit airborne transmission of pathogens to vulnerable patients and healthcare workers. However, bioaerosol sampling remains challenging because of the diversity of devices and methodologies and the very low airborne concentration of pathogens in real‐world settings, especially ...
Jessica Morel, Jean-Michel Lenoir, Camille Ménard, Samuel Le Hir, Clara Bourgeay, Tiago Zambujo, Emma Ensenat, Ibtissam Barhoumi, Mariana Gaboriau, Thomas Julien, Anaïs Proust, Manuel Rosa-Calatrava, Kalyani Sen   +12 more
wiley   +1 more source

Probing the role of point mutations in the cyp51A gene from Aspergillus fumigatus in the model yeast Saccharomyces cerevisiae [PDF]

, 2017
Azole-resistant strains of Aspergillus fumigatus have been detected and the underlying molecular mechanisms of resistance characterized. Point mutations in the cyp51A gene have been proved to be related to azole resistance in A.
Alcazar-Fuoli, L., Mellado, E., Sanglard, D., Cuenca-Estrella, M.   +3 more
core  

Cas9/CRISPR genome editing to demonstrate the contribution of Cyp51A Gly138Ser to azole resistance in Aspergillus fumigatus

, 2018
Azole resistance in Aspergillus fumigatus is predominantly associated with increased expression of Cyp51A (lanosterol 14α-demethylase), the target enzyme of azole antifungal agents, or with single-nucleotide polymorphisms (SNPs) in cyp51A.
Shigeki Nakamura, Tatsuya Inukai, Yasutaka Hoshino, Takashi Umeyama, Hisaki Shimosaka, Shogo Takatsuka, Satoshi Yamagoe, Katsuhiko Kamei, Kenji Ogawa, Yuta Hayashi, Minoru Nagi, Yoshitsugu Miyazaki   +11 more
core   +1 more source

First Report of Human Infection Caused by Aspergillus steynii and Analysis of Its Whole‐Genome Characteristics

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
The incidence of infections caused by rare pathogens has increased in recent years. This necessitates the development of effective diagnostic and therapeutic approaches. In this study, we report the first documented case of Aspergillus steynii‐induced pulmonary infection in humans.
Ruixuan Wang, Jingjing Chen, Na Wu, Min Yang, Ruiying Quan, Nan Xia, Hailong Li, Hua Nian, Ning Jiang, Yunzhuo Chu, Shitong Cheng, Sufei Tian, Nan-hua Chen   +12 more
wiley   +1 more source

Impact of the 29.9KD deletion on CYP51A and CYP51B expression and ergosterol levels.

, 2016
A. Induction of CYP51A in parental (A1163) and deletion mutant (Δ29.9) isolates 4 h after addition of 1 mg/L itraconazole (Δ29.9+I and A1160+I) or DMSO solvent control (Δ29.9 and A1160). B. Induction of CYP51B in parental (A1160) and deletion mutant (Δ29.
Mike Bromley (3150420), Paul Bowyer (21835), Natalya Kurbatova (3150414), Misha Kapushesky (3150417), Ivo Gut (69797), Maria Keays (3150426), David W. Denning (81132), Emma Davies (3150429), Anna Johns (3150432), Jane Mabey Gilsenan (3150423), Marcin Fraczek (21836), Marta Gut (203324)   +11 more
core   +1 more source

A Review on Aspergillosis in Turkey: As a Main Fungal Disease in Poultry

Veterinary Medicine and Science, Volume 11, Issue 6, November 2025.
ABSTRACT Background Aspergillosis, a fungal disease caused by various species of the genus Aspergillus, poses a significant threat to the health and productivity of turkeys. Objective The current review aims to synthesize current knowledge regarding the aetiology, pathogenesis, clinical manifestations, diagnostic methods and management strategies ...
Ansam Naji Aboud Alhassani, Abdulrahman T. Ahmed, Gaurav Sanghvi, Subbulakshmi Ganesan, Hussein Riyadh Abdul Kareem Al‐Hetty, I. B. Sapaev, Abhayveer Singh, Puneet Sudan, Yasser Fakri Mustafa, Majid Gholami‐Ahangaran   +9 more
wiley   +1 more source

The cdr1B efflux transporter is associated with non-cyp51a-mediated itraconazole resistance in aspergillus fumigatus

, 2013
<p>Objectives: Recent increases in triazole resistance in Aspergillus fumigatus have been attributed primarily to target site (cyp51A) mutations. A recent survey of resistant isolates in Manchester showed that >50% of resistant isolates had no ...
Bowyer, P., Buied, Ahmed, Fraczek, M.G., Bromley, M., Fraczek, Marcin G, Moore, C.B., Ramage, G., Richardson, Rautemaa-Richardson; id_orcid, Rajendran, R., Moore, Caroline B, Ramage, Gordon, Denning, D.W., Denning, David W; id_orcid, Bowyer, Paul, Rajendran, Ranjith, Rautemaa, R., Bromley, Michael; id_orcid, Buied, A.   +17 more
core   +1 more source