Results 71 to 80 of about 1,765 (165)

A Review on Aspergillosis in Turkey: As a Main Fungal Disease in Poultry

Veterinary Medicine and Science, Volume 11, Issue 6, November 2025.
ABSTRACT Background Aspergillosis, a fungal disease caused by various species of the genus Aspergillus, poses a significant threat to the health and productivity of turkeys. Objective The current review aims to synthesize current knowledge regarding the aetiology, pathogenesis, clinical manifestations, diagnostic methods and management strategies ...
Ansam Naji Aboud Alhassani, Abdulrahman T. Ahmed, Gaurav Sanghvi, Subbulakshmi Ganesan, Hussein Riyadh Abdul Kareem Al‐Hetty, I. B. Sapaev, Abhayveer Singh, Puneet Sudan, Yasser Fakri Mustafa, Majid Gholami‐Ahangaran   +9 more
wiley   +1 more source

Investigation of cgrA and cyp51A gene alternations in Aspergillus fumigatus strains exposed to kombucha fermented tea

Current Medical Mycology, 2019
Background and Purpose: Aspergillus fumigatus is one of the most common opportunistic fungus, which causes infection in immunocompromised and neutropenic patients. The current guidelines recommend voriconazole as the initial therapeutic and prophylactic agent for almost all cases, especially in patients with organ transplants, which leads to increased ...
Ladan Nazemi, Seyed Jamal Hashemi, Roshanak Daie Ghazvini, Mina Saeedi, Sadegh Khodavaisy, Aleksandra Barac, Mona Modiri, Maryam Akbari Dana, Zahra Zare shahrabadi Zare shahrabadi, Sassan Rezaie   +9 more
openaire   +3 more sources

Repositioning Antimicrobial Peptides Against WHO‐Priority Fungi

Advanced Science, Volume 12, Issue 37, October 6, 2025.
The growing burden of drug‐resistant fungal infections, driven by pathogens such as Candida auris, Cryptococcus neoformans, and Aspergillus fumigatus, underscores the urgent need for novel antifungal therapies. This review explores antimicrobial peptides as promising agents with membrane‐disruptive activity, immunomodulatory properties, and delivery ...
Cesar Augusto Roque‐Borda, Kaila Petronila Medina‐Alarcón, João Paulo Soler Gonçalves Pereira, Thais Cristina dos Anjos Sevilhano, Brigitte Aguilar‐Morón, Fernando Díaz‐Cárdenas, Lucas Silva da Cruz, Francisco Humberto Xavier‐Júnior, Eduardo Festozo Vicente, João Perdigão, Beatriz G. de la Torre, Fernando Albericio, Fernando Rogério Pavan   +12 more
wiley   +1 more source

Impact of cyp51A Mutations on the Pharmacokinetic and Pharmacodynamic Properties of Voriconazole in a Murine Model of Disseminated Aspergillosis [PDF]

Antimicrobial Agents and Chemotherapy, 2010
ABSTRACT The in vivo efficacy of voriconazole against 4 clinical Aspergillus fumigatus isolates with MICs ranging from 0.125 to 2 mg/liter (CLSI document M38A) was assessed in a nonneutropenic murine model of disseminated aspergillosis.
Mavridou, E., Bruggemann, R.J.M., Melchers, W.J.G., Verweij, P.E., Mouton, J.W.   +4 more
openaire   +4 more sources

Genetic analysis of azole-resistant Aspergillus fumigatus isolated from domestic and imported tulip bulbs in Japan

Journal of Global Antimicrobial Resistance
Objective: Azole-resistant Aspergillus fumigatus (ARAF) poses a significant clinical threat and is increasingly being isolated from agricultural environments.
Satomi Uehara, Hiroki Takahashi, Yukari Nishino, Yumi Takahashi, Takashi Chiba, Keiko Yokoyama, Hirofumi Miyake, Kenji Sadamasu, Daisuke Hagiwara   +8 more
doaj   +1 more source

Rate of cyp51A mutation in Aspergillus fumigatus among lung transplant recipients with targeted prophylaxis [PDF]

Journal of Antimicrobial Chemotherapy, 2015
Abstract Objectives The most common mechanism of azole (itraconazole and voriconazole) resistance in Aspergillus fumigatus is a mutation at the cyp51A locus. The aim of our study was to determine the rate of cyp51A mutations in lung transplant recipients (LTR) undergoing targeted antifungal ...
S, Shalhoub, M-L, Luong, S J, Howard, S, Richardson, L G, Singer, C, Chaparro, S, Keshavjee, Y, Akinlolu, C, Rotstein, T, Mazzulli, S, Husain   +10 more
openaire   +2 more sources

Development and validation of LAMP primer sets for rapid identification of Aspergillus fumigatus carrying the cyp51A TR46 azole resistance gene

Scientific Reports, 2021
Infections due to triazole-resistant Aspergillus fumigatus are increasingly reported worldwide and are associated with treatment failure and mortality. The principal class of azole-resistant isolates is characterized by tandem repeats of 34 bp or 46 bp ...
Plinio Trabasso, Tetsuhiro Matsuzawa, Teppei Arai, Daisuke Hagiwara, Yuzuru Mikami, Maria Luiza Moretti, Akira Watanabe   +6 more
doaj   +1 more source

Integrated Disease Management, Adaptation and Genomics of Fungal Plant Pathogens in Cropping Systems

Plant Pathology, Volume 74, Issue 6, Page 1445-1469, August 2025.
Knowledge of the fungal genome and multifaceted evolutionary forces need to be considered together in understanding and managing agricultural plant pathogen adaptation relative to integrated disease management (IDM) strategies. ABSTRACT Crop production systems contribute significantly to maintaining global food security. These systems often involve the
Hayley Wilson, Ido Bar, Kristy Hobson, Niloofar Vaghefi, Toni Petronaitis, Rebecca Ford   +5 more
wiley   +1 more source

cyp51A -Based Mechanisms of Aspergillus fumigatus Azole Drug Resistance Present in Clinical Samples from Germany [PDF]

Antimicrobial Agents and Chemotherapy, 2013
ABSTRACT Since the mid-1990s, a steady increase in the occurrence of itraconazole-resistant Aspergillus fumigatus isolates has been observed in clinical contexts, leading to therapeutic failure in the treatment of aspergillosis. This increase has been predominantly linked to a single allele of the
Bader, Oliver, Weig, Michael, Reichard, Utz, Lugert, Raimond, Kuhns, Martin, Christner, Martin, Held, Jürgen, Peter, Silke, Schumacher, Ulrike, Buchheidt, Dieter, Tintelnot, Kathrin, Groß, Uwe, Partners, MykoLabNet-D   +12 more
openaire   +4 more sources

Antifungal Resistance in Non‐fumigatus Aspergillus Species

Mycoses, Volume 68, Issue 4, April 2025.
ABSTRACT This review provides an in‐depth exploration of antifungal resistance in non‐fumigatus Aspergillus species, mainly focusing on acquired resistance. The available data have been compiled and sometimes re‐analysed. It highlights the increasing prevalence of resistance in non‐fumigatus species belonging to Flavi, Terrei, Nigri, and Nidulantes ...
Elie Djenontin, Rose‐Anne Lavergne, Florent Morio, Eric Dannaoui   +3 more
wiley   +1 more source