Results 91 to 100 of about 1,046 (126)

The 34 mer is essential for activation of cyp51A gene expression and azole resistance.

, 2016
(A) cyp51A transcript levels in strains lacking the 34 mer (cyp51AΔ34) and strains carrying TR34 (cyp51ATR34) have been measured using RT-qPCR (gpdA was used as reference gene).
Bharat Rash (46771), Paul Bowyer (21835), Peter Hortschansky (67975), Axel A. Brakhage (199110), Christoph Müller (2452525), Michael J. Bromley (135301), Hubertus Haas (194198), Javier Capilla (1681036), Franz Bracher (458039), Takanori Furukawa (2885306), Paul D. Carr (550106), Fabio Gsaller (240729)   +11 more
core   +1 more source

Directed evolution of the pathogenic mold Aspergillus fumigatus reveals novel genes contributing to triazole resistance

Antimicrobial Agents and Chemotherapy
Aspergillus fumigatus is the leading cause of invasive mold infections in immunocompromised patients. Current antifungal treatment primarily depends on the triazole antifungals, which act by inhibiting Erg11/Cyp51, a key enzyme in the ergosterol ...
Mariana Handelman, Argha Sarkar, Avital Varshavsky, Yona Shadkchan, Xuefei Chen, Gerard D. Wright, Endrews Delbaje, Bradley Laflamme, Sara Fallah, Evelyne Côté, Nicole Robbins, Thaila Fernanda dos Reis, Gustavo H. Goldman, Leah E. Cowen, Nir Osherov   +14 more
doaj   +1 more source

Transcriptomic and metabolomic analysis of a non-cyp51A mutant azole-resistant Aspergillus fumigatus isolated from Ningxia, China

Frontiers in Microbiology
BackgroundAzole-resistant A. fumigatus (Aspergillus fumigatus) has been extensively documented both domestically and internationally, with mutations in the cyp51A gene identified as the predominant mechanism of resistance.
Wanting Ma, Yuting Kang, Yuting Kang, Qiujie Li, Pengtao Wang, Wei Jia, Wei Jia   +6 more
doaj   +1 more source

Three-dimensional models of 14α-sterol demethylase (Cyp51A) from Aspergillus lentulus and Aspergillus fumigatus: an insight into differences in voriconazole interaction

, 2011
International audience, an sibling species, is increasingly reported in corticosteroid-treated patients. Its clinical significance is unknown, but the fact that shows reduced antifungal susceptibility, mainly to voriconazole, is of serious concern ...
Alcazar-Fuoli, Laura, Alcazar-Fuoli, L., Mellado, E., Rodriguez-Tudela, J.L., Cuesta, I., Emilia Mellado, Mellado, Emilia, Isabel Cuesta, Cuenca-Estrella, Manuel, Manuel Cuenca-Estrella, Juan L. Rodriguez-Tudela, Rodriguez-Tudela, Juan L., Cuesta, Isabel, Sanglard, Dominique, Laura Alcazar-Fuoli, Dominique Sanglard, Sanglard, D., Cuenca-Estrella, M.   +17 more
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Gene-specific transcriptional activation by the Aspergillus fumigatus AtrR factor requires a conserved C-terminal domain

mSphere
Treatment of fungal infections associated with the filamentous fungus Aspergillus fumigatus is becoming more problematic as this organism is developing resistance to the main chemotherapeutic drug at an increasing rate.
Shivani Ror, Mark A. Stamnes, W. Scott Moye-Rowley   +2 more
doaj   +1 more source

Pharmacophore-Based Virtual Screening of Novel Inhibitors and Docking Analysis for CYP51A from Penicillium italicum

, 2017
Sterol 14α-demethylases from Cytochrome P450 family (CYP51s) are essential enzymes in sterol biosynthesis and well-known as the target of antifungal drugs.
Yuhui Niu, Yongze Yuan, Rui Han, Jinhui Yu, Tingfu Zhang, Jiali Mao, Shengqiang Wang, Qianwen Cao, Deli Liu   +8 more
core   +1 more source

Epidemiology and Azole Resistance of Clinical Isolates of Aspergillus fumigatus from a Large Tertiary Hospital in Ningxia, China

Infection and Drug Resistance
Yuting Kang,1,* Qiujie Li,2,* Yao Yao,3 Chao Xu,2 Zhuoran Qiu,2 Wei Jia,1,3 Gang Li,1,3 Pengtao Wang1 1Ningxia Key Laboratory of Clinical and Pathogenic Microbiology, Institute of Medical Sciences, General Hospital of Ningxia Medical University ...
Kang Y, Li Q, Yao Y, Xu C, Qiu Z, Jia W, Li G, Wang P   +7 more
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Detection of CYP51A mutations in airborne Aspergillus spp isolates from intrahospital environments

, 2022
: Introduction: Aerobiological studies have found an increasing number of fungal taxa in the intrahospital environments, including Aspergillus species.
Aristizabal Quintero, Mariana, Rúa Giraldo, Alvaro León, Zuleta González, María Camila, Hernández Ruiz, Orville, López García, Angela María, Torres Morales, Susana, Jiménez Zapata, Liliana, Gómez Guzmán, Oscar Mauricio   +7 more
core  

CYP51A mRNA levels in the 4 sequential A. fumigatus isolates and in a control wild type isolate AZN 8196 (WT) and a tri-azole resistant control isolate with over-expression of the CYP51A gene due to the L98H mutation and promoter tandem repeat.

, 2013
CYP51A mRNA levels in the 4 sequential A. fumigatus isolates and in a control wild type isolate AZN 8196 (WT) and a tri-azole resistant control isolate with over-expression of the CYP51A gene due to the L98H mutation and promoter tandem repeat.
Humara Khan (365662), Maiken Cavling Arendrup (365657), Willem J. G. Melchers (17311), Paul E. Verweij (118614), Niels Frimodt-Møller (68909), Klaus Leth Mortensen (365661), Eleftheria Mavridou (365659), Eveline Snelders (118613)   +7 more
core   +1 more source

Molecular Identification of Aspergillus Species, Antifungal Susceptibility, and Phenotypic Identification of Azole-Resistant Mutations in Cyp51A Gene Isolated from Xinjiang

Infection and Drug Resistance
Aikedai Yusufu, Zubaidanmu Aizezi, Xiyidan Nuermaimaiti, Yiting Liu, Xiaodong Wang Department of Dermatology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, People’s Republic of ChinaCorrespondence: Xiaodong Wang, Department of ...
Yusufu A, Aizezi Z, Nuermaimaiti X, Liu Y, Wang X   +4 more
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