Results 91 to 100 of about 1,765 (165)

Gene-specific transcriptional activation by the Aspergillus fumigatus AtrR factor requires a conserved C-terminal domain

mSphere
Treatment of fungal infections associated with the filamentous fungus Aspergillus fumigatus is becoming more problematic as this organism is developing resistance to the main chemotherapeutic drug at an increasing rate.
Shivani Ror, Mark A. Stamnes, W. Scott Moye-Rowley   +2 more
doaj   +1 more source

Epidemiology and Azole Resistance of Clinical Isolates of Aspergillus fumigatus from a Large Tertiary Hospital in Ningxia, China

Infection and Drug Resistance
Yuting Kang,1,* Qiujie Li,2,* Yao Yao,3 Chao Xu,2 Zhuoran Qiu,2 Wei Jia,1,3 Gang Li,1,3 Pengtao Wang1 1Ningxia Key Laboratory of Clinical and Pathogenic Microbiology, Institute of Medical Sciences, General Hospital of Ningxia Medical University ...
Kang Y, Li Q, Yao Y, Xu C, Qiu Z, Jia W, Li G, Wang P   +7 more
doaj  

Unveiling environmental transmission risks: comparative analysis of azole resistance in Aspergillus fumigatus clinical and environmental isolates from Yunnan, China

Microbiology Spectrum
Azole resistance in Aspergillus fumigatus poses a significant clinical challenge globally. Our previous epidemiological analysis revealed a remarkably high frequency (~80%) of azole-resistant A.
Jianchuan Gong, Jiarui Huang, Yongju Liu, Ying Zhang, Yuhong Gao   +4 more
doaj   +1 more source

Fungicide Sensitivity Profile of Pyrenophora teres f. teres in Field Population

Journal of Fungi
Pyrenophora teres f. teres (Ptt) is a severe pathogen to spring barley in Northern Europe. Ptt with relevant mutations in fungicide target proteins, sterol 14α-demethylase (CYP51A), cytochrome b (Cyt b), and succinate dehydrogenase (SDH) would put ...
Regina Pütsepp, Andres Mäe, Lee Põllumaa, Liis Andresen, Riinu Kiiker   +4 more
doaj   +1 more source

Molecular Identification of Aspergillus Species, Antifungal Susceptibility, and Phenotypic Identification of Azole-Resistant Mutations in Cyp51A Gene Isolated from Xinjiang

Infection and Drug Resistance
Aikedai Yusufu, Zubaidanmu Aizezi, Xiyidan Nuermaimaiti, Yiting Liu, Xiaodong Wang Department of Dermatology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, People’s Republic of ChinaCorrespondence: Xiaodong Wang, Department of ...
Yusufu A, Aizezi Z, Nuermaimaiti X, Liu Y, Wang X   +4 more
doaj  

Commercial Methods for Antifungal Susceptibility Testing of Saprophytic Molds: Can They Be Used to Detect Resistance?

Journal of Fungi
Commercial tests are often employed in clinical microbiology laboratories for antifungal susceptibility testing of filamentous fungi. Method-dependent epidemiological cutoff values (ECVs) have been defined in order to detect non-wild-type (NWT) isolates ...
Paschalis Paranos, Ana Espinel-Ingroff, Joseph Meletiadis   +2 more
doaj   +1 more source

Genomic variant-driven prediction of azole resistance in Aspergillus fumigatus using GWAS and machine learning

Frontiers in Microbiology
Azole resistance in Aspergillus fumigatus, a major cause of invasive aspergillosis, threatens public health. Known drivers include cyp51A/B mutations (e.g., TR34/L98H and TR46/Y121F/T289A), yet existing studies have largely focused on clinical isolates ...
Dingchen Li, Dingchen Li, Xinkai Yue, Xinkai Yue, Xinkai Yue, Wenjuan Hu, Wenjuan Hu, Hanying Zhong, Fangyan Chen, Jingya Zhao, Luyao Cao, Xia Chen, Li Han   +12 more
doaj   +1 more source

Interrogation of related clinical pan-azole resistant Aspergillus fumigatus strains – G138C, Y431C and G434C SNPs in cyp51A, Upregulation of cyp51A and integration and activation of transposon Atf1 into cyp51A promoter. [PDF]

Journal of clinical microbiology, 2011
Albarrag, AM, Anderson, MJ, Howard, SJ, Robson, GD, Warn, PA, Sanglard, D, Denning, DW.; id_orcid 0000-0001-5626-2251   +6 more
openaire   +1 more source

Can voriconazole gradient diffusion testing results be extrapolated to isavuconazole and posaconazole in <i>Aspergillus</i> spp.? Comparative analysis with CLSI broth microdilution and <i>cyp51A</i> gene sequencing. [PDF]

Antimicrob Agents Chemother
Vahedi-Shahandashti R, Nickel A-S, Eisele D, Lass-Flörl C, ISHAM Working Group Member of Intrinsic Antifungal Resistance.   +4 more
europepmc   +1 more source

Prevalence of cyp51A variants in a US collection of Aspergillus fumigatus clinical isolates and comparative analysis of their contribution to triazole antifungal resistance. [PDF]

J Antimicrob Chemother
Gómez Londoño LF, Souza ACO, Burt B, Das S, Ge W, Meza-Perez V, Wiederhold NP, Shelat AA, Cuomo CA, Fortwendel JR, Rogers PD.   +10 more
europepmc   +1 more source