Results 81 to 90 of about 1,765 (165)

The Medical Triazole Voriconazole Can Select for Tandem Repeat Variations in Azole-Resistant Aspergillus Fumigatus Harboring TR₃₄/L98H Via Asexual Reproduction

Journal of Fungi, 2020
Azole-resistant Aspergillus fumigatus isolates recovered at high frequency from patients, harbor mutations that are associated with variation of promoter length in the cyp51A gene.
Jianhua Zhang, Jan Zoll, Tobias Engel, Joost van den Heuvel, Paul E. Verweij, Alfons J. M. Debets   +5 more
doaj   +1 more source

Intrinsic and Acquired Antimicrobial Resistomes in Plant Microbiomes: Implications for Agriculture and Public Health

Journal of Sustainable Agriculture and Environment, Volume 4, Issue 1, March 2025.
ABSTRACT Antimicrobial resistance (AMR) poses a significant threat to both human and environmental health. Before human intervention, the natural resistome existed in a relatively balanced state, mainly regulated by microbial interactions and environmental factors.
Denis Kiplimo, Romano Mwirichia, Wisnu Adi Wicaksono, Gabriele Berg, Ahmed Abdelfattah   +4 more
wiley   +1 more source

Suppressed Protein Translation Caused by MSP‐8 Deficiency Determines Fungal Multidrug Resistance with Fitness Cost

Advanced Science, Volume 12, Issue 6, February 10, 2025.
This study identifies msp‐8 as a novel multidrug‐resistance gene encoding a helicase in fungi, and reveals a previously unrecognized resistance mechanism. Dysfunction of MSP‐8 disrupts translation homeostasis, leading to reductions in intracellular ketoconazolelevels, membrane‐bound amphotericin B contents, and reactive oxygen species.
Mi Zhou, Pengju Yu, Chengcheng Hu, Wenxia Fang, Cheng Jin, Shaojie Li, Xianyun Sun   +6 more
wiley   +1 more source

Sterol Biosynthesis and Azole Tolerance Is Governed by the Opposing Actions of SrbA and the CCAAT Binding Complex.

PLoS Pathogens, 2016
Azole drugs selectively target fungal sterol biosynthesis and are critical to our antifungal therapeutic arsenal. However, resistance to this class of drugs, particularly in the major human mould pathogen Aspergillus fumigatus, is emerging and reaching ...
Fabio Gsaller, Peter Hortschansky, Takanori Furukawa, Paul D Carr, Bharat Rash, Javier Capilla, Christoph Müller, Franz Bracher, Paul Bowyer, Hubertus Haas, Axel A Brakhage, Michael J Bromley   +11 more
doaj   +1 more source

Paradoxal Trends in Azole-Resistant Aspergillus fumigatus in a National Multicenter Surveillance Program, the Netherlands, 2013–2018

Emerging Infectious Diseases, 2020
We investigated the prevalence of azole resistance of Aspergillus fumigatus isolates in the Netherlands by screening clinical A. fumigatus isolates for azole resistance during 2013–2018.
Pieter P.A. Lestrade, Jochem B. Buil, Martha T. van der Beek, Ed J. Kuijper, Karin van Dijk, Greetje A. Kampinga, Bart J.A. Rijnders, Alieke G. Vonk, Sabine C. de Greeff, Annelot F. Schoffelen, Jaap van Dissel, Jacques F. Meis, Willem J.G. Melchers, Paul E. Verweij   +13 more
doaj   +1 more source

The Significance of Mono‐ and Dual‐Effective Agents in the Development of New Antifungal Strategies

Chemical Biology &Drug Design, Volume 105, Issue 1, January 2025.
The future of treating challenging fungal infections lies in novel therapies targeting new antifungal targets, overcoming resistance mechanisms, and exploring innovative dual inhibitors. ABSTRACT Invasive fungal infections (IFIs) pose significant challenges in clinical settings, particularly due to their high morbidity and mortality rates.
Cengiz Zobi, Oztekin Algul
wiley   +1 more source

Itraconazole, Voriconazole, and Posaconazole CLSI MIC Distributions for Wild-Type and Azole-Resistant Aspergillus fumigatus Isolates

Journal of Fungi, 2018
Azole resistance in Aspergillus fumigatus is most frequently conferred by mutations in the cyp51A gene encoding 14α-sterol demethylases. TR34/L98H and TR46/Y121F/T289A are the two most common mutations associated with environmental resistance ...
Jochem B. Buil, Ferry Hagen, Anuradha Chowdhary, Paul E. Verweij, Jacques F. Meis   +4 more
doaj   +1 more source

Aspergillus tubingensis: A Rare Fungal Pathogen Complicating COVID‐19 Case

Case Reports in Infectious Diseases, Volume 2025, Issue 1, 2025.
Background Coronavirus disease 2019 (COVID‐19) has been associated with invasive fungal infection. Several COVID‐19 cases were complicated due to coinfection with Aspergillus, Rhizopus, and Mucor species. We present COVID‐19 with Aspergillus tubingensis coinfection.
Aiah M. Khateb, Fadwa S. Alofi, Abdullah Z. Almutairi, Mohammad A. Turkistani, Ziab Z. Alahmadey, Hessa A. Al-Sharif, Esam I. Azhar, Dawei Cui   +7 more
wiley   +1 more source

Variability in competitive fitness among environmental and clinical azole-resistant Aspergillus fumigatus isolates

mBio
Azoles are the primary antifungal drugs used to treat infections caused by Aspergillus fumigatus. However, the emergence of azole resistance in A. fumigatus has become a global health concern despite the low proportion of resistant isolates in natural ...
Shu Chen, Guoxing Zhu, Huiping Lin, Jian Guo, Shuwen Deng, Wenjuan Wu, Gustavo H. Goldman, Ling Lu, Yuanwei Zhang   +8 more
doaj   +1 more source

Examination of cyp51A and cyp51B expression level of the first Polish azole resistant clinical Aspergillus fumigatus isolate

Acta Biochimica Polonica, 2015
Aspergillus fumigatus is one of the most prevalent airborne fungal pathogens causing infections worldwide. Most A. fumigatus strains are susceptible to azoles, which are administered as the first line therapeutics. However, during last decade the acquired resistance to triazoles by these species has been described.
Anna, Brillowska-Dąbrowska, Martyna, Mroczyńska, Urszula, Nawrot, Katarzyna, Włodarczyk, Ewelina, Kurzyk   +4 more
openaire   +2 more sources