Results 81 to 90 of about 1,046 (126)

Widespread Occurrence of a CYP51A Pseudogene in Calonectria pseudonaviculata

Mycobiology, 2020
Calonectria pseudonaviculata and C. henricotiae are two closely related fungal species responsible for boxwood blight disease of ornamental shrubs (Buxus spp.) in the U.S. and Europe.
Stefanos Stravoravdis, Nicholas R. LeBlanc, Robert E. Marra, Jo Anne Crouch, Jonathan P. Hulvey   +4 more
doaj   +1 more source

Sterol Biosynthesis and Azole Tolerance Is Governed by the Opposing Actions of SrbA and the CCAAT Binding Complex.

PLoS Pathogens, 2016
Azole drugs selectively target fungal sterol biosynthesis and are critical to our antifungal therapeutic arsenal. However, resistance to this class of drugs, particularly in the major human mould pathogen Aspergillus fumigatus, is emerging and reaching ...
Fabio Gsaller, Peter Hortschansky, Takanori Furukawa, Paul D Carr, Bharat Rash, Javier Capilla, Christoph Müller, Franz Bracher, Paul Bowyer, Hubertus Haas, Axel A Brakhage, Michael J Bromley   +11 more
doaj   +1 more source

Mutación r30q en cyp51a de neocosmospora solani asociada a resistencia a azoles

, 2021
Neocosmospora and Fusarium are the etiological agents of human fusariosis such as onychomycosis, fungal keratitis and disseminated infections, and the most widely reported species are Neocosmospora keratoplastica, Neocosmospora falciformis and Fusarium ...
Lizcano Salas, Andrés Felipe
core  

Itraconazole, Voriconazole, and Posaconazole CLSI MIC Distributions for Wild-Type and Azole-Resistant Aspergillus fumigatus Isolates

Journal of Fungi, 2018
Azole resistance in Aspergillus fumigatus is most frequently conferred by mutations in the cyp51A gene encoding 14α-sterol demethylases. TR34/L98H and TR46/Y121F/T289A are the two most common mutations associated with environmental resistance ...
Jochem B. Buil, Ferry Hagen, Anuradha Chowdhary, Paul E. Verweij, Jacques F. Meis   +4 more
doaj   +1 more source

Characteristics of individual cyp51A SNPs and combinations thereof impacting the azole phenotype in TR34-mediated resistance genotypes of Aspergillus fumigatus

Antimicrobial Agents and Chemotherapy
The World Health Organization has flagged the rise of drug resistance in Aspergillus fumigatus as a critical concern. Elevated mutation rates in this pathogen contribute to the rapid development of resistance, complicating treatment efforts. We conducted
Yinggai Song, Jochem B. Buil, Jan Zoll, Marlou Tehupeiory-Kooreman, Hanka Venselaar, Ruoyu Li, Willem J. G. Melchers, Paul E. Verweij   +7 more
doaj   +1 more source

Can voriconazole gradient diffusion testing results be extrapolated to isavuconazole and posaconazole in Aspergillus spp.? Comparative analysis with CLSI broth microdilution and cyp51A gene sequencing

Antimicrobial Agents and Chemotherapy
This study assessed whether voriconazole (VRC) gradient diffusion results can be extrapolated to isavuconazole (ISA) and posaconazole (PSC) in Aspergillus fumigatus and Aspergillus terreus by comparison with the Clinical and Laboratory Standards ...
Roya Vahedi-Shahandashti, Anna-Sophia Nickel, David Eisele, Cornelia Lass-Flörl   +3 more
doaj   +1 more source

Surveillance for azole resistance in clinical and environmental isolates of Aspergillus fumigatus in Australia and cyp51A homology modelling of azole-resistant isolates

, 2018
Background: The prevalence of azole resistance in Aspergillus fumigatus is uncertain in Australia. Azole exposure may select for resistance. We investigated the frequency of azole resistance in a large number of clinical and environmental isolates ...
Park, R., Park, Robert F, Lopez-Ruiz, Francisco J, Louise Cooley, Chen, Sharon C-A, Robert F Park, Talbot, J., Cooley, L., Harper, Lincoln, Barrs, Vanessa R, Lopez-Ruiz, Fran, William S Cuddy, Harper, L., David E Hibbs, Sorrell, T., Jessica J Talbot, Subedi, Shradha, Biswas, Chayanika, Francisco J Lopez-Ruiz, Vanessa R Barrs, Biswas, C., Lincoln Harper, Hibbs, David E, Cuddy, William S, Chayanika Biswas, Tania C Sorrell, Subedi, S., Dee Carter, Catriona L Halliday, Carter, Dee, Lai, F., Halliday, C., Lai, Felcia, Barrs, V., Sorrell, Tania C, Chen, S., Shradha Subedi, Hibbs, D., Cuddy, W., Felcia Lai, Cooley, Louise, Carter, D., Halliday, Catriona L, Sharon C -A Chen, Talbot, Jessica J   +44 more
core   +1 more source

cyp51A-Based Mechanisms of Aspergillus fumigatus Azole Drug Resistance Present in Clinical Samples from Germany

, 2013
Since the mid-1990s, a steady increase in the occurrence of itraconazole-resistant Aspergillus fumigatus isolates has been observed in clinical contexts, leading to therapeutic failure in the treatment of aspergillosis.
Lugert, Raimond, Reichard, Utz, Kuhns, Martin, Schumacher, Ulrike, Held, Jürgen, Weig, Michael S., Peter, Silke, Gross, Uwe, Christner, Martin, Tintelnot, Kathrin, Buchheidt, Dieter, Bader, Oliver, Held, Juergen, Weig, Michael, Partners, MykoLabNet-D   +14 more
core   +1 more source

Substitutions at methionine 220 in the 14alpha-sterol demethylase (Cyp51A) of Aspergillus fumigatus are responsible for resistance in vitro to azole antifungal drugs [PDF]

, 2004
Five clinical isolates of Aspergillus fumigatus that exhibited similar patterns of reduced susceptibility to itraconazole and other triazole drugs were analyzed.
Alcazar-Fuoli, Laura, Cuenca-Estrella, Manuel, Rodriguez-Tudela, Juan Luis, Garcia-Effron, Guillermo, Mellado, Emilia   +4 more
core   +1 more source

Chromatin immunoprecipitation assay showing binding of AtrR protein to the promoter regions of cyp51A and cdr1B.

, 2017
(A) Chromatin immunoprecipitation (ChIP) was done using a mouse monoclonal antibody directed against the HA epitope. Crosslinked chromatin was prepared from a WT strain or an isogenic strain expressing a 3x HA-tagged form of atrR (shown as atrR-3× HA ...
Susumu Kawamoto (47745), Sanjoy Paul (383064), Katsuhiko Kamei (491451), Katsuya Gomi (415848), Ayumi Ohba (3615200), Daisuke Hagiwara (276944), Tohru Gonoi (459658), Akira Watanabe (134585), Daisuke Miura (210283), W. Scott Moye-Rowley (3615197), Kiminori Shimizu (276946), Takahiro Shintani (3615203)   +11 more
core   +1 more source