Results 101 to 110 of about 1,046 (126)

Unveiling environmental transmission risks: comparative analysis of azole resistance in Aspergillus fumigatus clinical and environmental isolates from Yunnan, China

Microbiology Spectrum
Azole resistance in Aspergillus fumigatus poses a significant clinical challenge globally. Our previous epidemiological analysis revealed a remarkably high frequency (~80%) of azole-resistant A.
Jianchuan Gong, Jiarui Huang, Yongju Liu, Ying Zhang, Yuhong Gao   +4 more
doaj   +1 more source

Commercial Methods for Antifungal Susceptibility Testing of Saprophytic Molds: Can They Be Used to Detect Resistance?

Journal of Fungi
Commercial tests are often employed in clinical microbiology laboratories for antifungal susceptibility testing of filamentous fungi. Method-dependent epidemiological cutoff values (ECVs) have been defined in order to detect non-wild-type (NWT) isolates ...
Paschalis Paranos, Ana Espinel-Ingroff, Joseph Meletiadis   +2 more
doaj   +1 more source

Fungicide Sensitivity Profile of Pyrenophora teres f. teres in Field Population

Journal of Fungi
Pyrenophora teres f. teres (Ptt) is a severe pathogen to spring barley in Northern Europe. Ptt with relevant mutations in fungicide target proteins, sterol 14α-demethylase (CYP51A), cytochrome b (Cyt b), and succinate dehydrogenase (SDH) would put ...
Regina Pütsepp, Andres Mäe, Lee Põllumaa, Liis Andresen, Riinu Kiiker   +4 more
doaj   +1 more source

Single-tube PCR coupled with mini-sequencing assay for the detection of cyp51A and cyp51B polymorphisms in Aspergillus fumigatus

, 2015
Aim: Triazole resistance in Aspergillus fumigatus is associated with mutations in cyp51 genes, therefore, a single-tube multiplex PCR was proposed for rapid detection of such mutations. Methods: Relevant markers (n = 21) located in cyp51A and cyp51B were
Araujo, Ricardo, Amorim, Antonio, Gungor, Ozge   +2 more
core   +1 more source

Detection of Azole Drug Resistance of the Aspergillus Species Cyp51a Gene by PCR

Journal of Medical Sciences and Health, 2019
Background: Allergic bronchopulmonary aspergillosis (ABPA) is a hypersensitivity pulmonary disease occurring in individuals with asthma or cystic fibrosis.
Raksha, Gurjeet Singh, A D Urhekar
doaj  

Epidemiological cutoff values for azoles and Aspergillus fumigatus based on a novel mathematical approach incorporating cyp51A sequence analysis

, 2012
Epidemiological cutoff values (ECV) are commonly used to separate wild-type isolates from isolates with reduced susceptibility to antifungal drugs, thus setting the foundation for establishing clinical breakpoints for Aspergillus fumigatus. However, ECVs
Melchers, W.J.G., Meletiadis, J., Mouton, J.W., Mavridou, E., Verweij, P.E.   +4 more
core   +1 more source

Antifungal Susceptibility and Genotypic Analysis of cyp51A Mutations in Aspergillus fumigatus Isolates in Malaysia

Infection and Drug Resistance
Xue Ting Tan, Nurin Nazirah Binti Mokhtar, Shirley Yi Fen Hii, Fairuz Amran Bacteriology Unit, Infectious Diseases Research Centre, Institute for Medical Research, National Institute of Health, Ministry of Health Malaysia, Setia Alam, Selangor ...
Tan XT, Mokhtar NN, Hii SYF, Amran F
doaj  

Insight into the Significance of Aspergillus fumigatus cyp51A Polymorphisms.

Antimicrobial Agents and Chemotherapy, 2018
Triazole antifungal compounds are the first treatment choice for invasive aspergillosis. However, in the last decade the rate of azole resistance among Aspergillus fumigatus strains has increased notoriously.
Laura Alcazar Fuoli, Sara Monzón, Isabel Cuesta   +2 more
exaly   +2 more sources

Contributions of both ATP-Binding Cassette Transporter and Cyp51A Proteins Are Essential for Azole Resistance in Aspergillus fumigatus.

Antimicrobial Agents and Chemotherapy, 2017
While azole drugs targeting the biosynthesis of ergosterol are effective antifungal agents, their extensive use has led to the development of resistant organisms.
Sanjoy Paul, W Scott Moye-Rowley
exaly   +2 more sources

cyp51A Mutations, Extrolite Profiles, and Antifungal Susceptibility in Clinical and Environmental Isolates of the Aspergillus viridinutans Species Complex.

Antimicrobial Agents and Chemotherapy, 2019
The past decade has seen an increase in aspergillosis in humans and animals due to Aspergillus viridinutans species complex members. Azole resistance is common to these infections, carrying a poor prognosis.
Vanessa Rosemary Duke Barrs, Jens Christian Frisvad, David E. Hibbs   +2 more
exaly   +2 more sources