Results 51 to 60 of about 1,765 (165)
Sequence variation in CYP51A from the Y strain of Trypanosoma cruzi alters its sensitivity to inhibition [PDF]
FEBS Letters, 2014 CYP51 (sterol 14α‐demethylase) is an efficient target for clinical and agricultural antifungals and an emerging target for treatment of Chagas disease, the infection that is caused by multiple strains of a protozoan pathogen Trypanosoma cruzi. Here, we analyze CYP51A from the Y strain T. cruzi.
Cherkesova, Tatiana S. +6 more
openaire +3 more sources
Afu-Emi1 Contributes to Stress Adaptation and Voriconazole Susceptibility in Aspergillus fumigatus
Microbiology Spectrum, 2023 Invasive aspergillosis (IA) is the second most common invasive fungal disease and is associated with high mortality rates. Aspergillus fumigatus is the predominant causal agent of this life-threatening infection.
Jufang Tan +3 more
doaj +1 more source
Frontiers in Microbiology, 2018 Aspergillus fumigatus triazole resistance is an emerging concern for treating chronically infected/colonized patients. This study sought to evaluate the performance of PCR assays to detect Aspergillus fungi together with azole resistance in sputum ...
Hélène Guegan +7 more
doaj +1 more source
Veterinary Dermatology, EarlyView.ABSTRACT Background An increased number of dogs with unresolved yeast otitis externa (OE) after miconazole treatment was observed at a tertiary practice. Hypothesis/Objectives To evaluate miconazole susceptibility in Malassezia pachydermatis isolates from canine OE.
Cole M. Belcher +5 more
wiley +1 more source
Medical Mycology, 2022 Abstract Poster session 1, September 21, 2022, 12:30 PM - 1:30 PM Introduction Aerobiological studies have found an increasing number of fungal taxa in the intrahospital environments, including Aspergillus species. There is a gap in
López, Angela María +7 more
openaire +1 more source
Food Frontiers, Volume 7, Issue 4, July 2026.Antifungal effects and underlying mechanism of the action of the supercritical fluid extracted from the cumin (Cuminum cyminum) seeds and its volatile phyto‐constituents against pathogenic Aspergillus fumigatus. ABSTRACT Spices are aromatic culinary ingredients used worldwide for enhancing food flavors, folklore therapy, and their antiseptic ...
Acharya Balkrishna +7 more
wiley +1 more source
Structural basis of HapE P88L -linked antifungal triazole resistance in Aspergillus fumigatus
Life Science Alliance, 2020 The mutation P88L in subunit HapE of the CCAAT transcription factor causes resistance of Aspergillus fumigatus to azole drugs due to altered binding, bending, and transcription of target promoters.
Peter Hortschansky +8 more
doaj +1 more source
Experimental and in-host evolution of triazole resistance in human pathogenic fungi
Frontiers in Fungal Biology, 2022 The leading fungal pathogens causing systemic infections in humans are Candida spp., Aspergillus fumigatus, and Cryptococcus neoformans. The major class of antifungals used to treat such infections are the triazoles, which target the cytochrome P450 ...
Mariana Handelman, Nir Osherov
doaj +1 more source
Pest Management Science, Volume 82, Issue 7, Page 5971-5986, July 2026.RNA interference (RNAi) technologies, host‐induced gene silencing (HIGS) and spray‐induced gene silencing (SIGS), potentially offer sustainable crop protection. However, efficacy, costs, regulatory clarity, and socio‐environmental impacts require further evaluation for broader use.
Elisabetta Sergi +12 more
wiley +1 more source
A simple method to detect the tandem repeat of the cyp51A promoter in azole-resistant strains of Aspergillus fumigatus [PDF]
Medical Mycology, 2018 We designed primers and cycling probes to detect the tandem repeat (TR) of cyp51A promoter in Aspergillus fumigatus. A control-probe was designed to anneal to the outside of the TR region, whereas a TR-probe was designed to anneal to the inside of the TR region. For amplification and probe-hydrolysis detection, the CycleavePCR system was used. Although
Takahito, Toyotome +3 more
openaire +2 more sources