Results 51 to 60 of about 1,046 (126)

Experimental and in-host evolution of triazole resistance in human pathogenic fungi

Frontiers in Fungal Biology, 2022
The leading fungal pathogens causing systemic infections in humans are Candida spp., Aspergillus fumigatus, and Cryptococcus neoformans. The major class of antifungals used to treat such infections are the triazoles, which target the cytochrome P450 ...
Mariana Handelman, Nir Osherov
doaj   +1 more source

RNA interference in crop protection: opportunities and challenges during the transition to commercialization

Pest Management Science, Volume 82, Issue 7, Page 5971-5986, July 2026.
RNA interference (RNAi) technologies, host‐induced gene silencing (HIGS) and spray‐induced gene silencing (SIGS), potentially offer sustainable crop protection. However, efficacy, costs, regulatory clarity, and socio‐environmental impacts require further evaluation for broader use.
Elisabetta Sergi, Anna Narduzzo, Alessandra Di Canito, Francesco Favaretto, Luca Nerva, Walter Chitarra, Lucia Bologna, Jacopo Bacenetti, Giuliana Maddalena, Simona Masiero, Ileana Vigentini, Gabriella De Lorenzis, Silvia Laura Toffolatti   +12 more
wiley   +1 more source

Deciphering Aspergillus fumigatus cyp51A-mediated triazole resistance by pyrosequencing of respiratory specimens

, 2020
Background: Infections caused by triazole drug-resistant Aspergillus fumigatus are an increasing problem. The sensitivity of standard culture is poor, abrogating susceptibility testing.
Moore, Caroline B, Novak-Frazer, Lilyann; id_orcid, Richardson, Malcolm D, Denning, David W; id_orcid, Rautemaa-Richardson, Riina; id_orcid, Anees-Hill, Samuel P, Masania, Rikesh, Hassan, Darin   +7 more
core   +1 more source

Molecular confirmation of the linkage between the rhizopus oryzae CYP51A gene coding region and its intrinsic voriconazole and fluconazole resistance [PDF]

, 2018
Rhizopus oryzae is the most prevalent causative agent of mucormycosis, an increasingly reported opportunistic fungal infection. These Mucorales are intrinsically resistant to Candida- and Aspergillus-active antifungal azole drugs, such as fluconazole ...
Cabeza, Matías Sebastián, Dudiuk, Catiana Beatriz, Laura Theill, Soledad Gamarra, Gamarra, Soledad, Theill, Laura, Garcia, Guillermo Manuel, Macedo, Daiana, Catiana Dudiuk, Daiana Macedo, Florencia Leonardelli, Guillermo Garcia-Effron, Matías S. Cabeza, Leonardelli, Florencia   +13 more
core   +1 more source

Point Mutations in the 14-α Sterol Demethylase Cyp51A or Cyp51C Could Contribute to Azole Resistance in Aspergillus flavus. [PDF]

, 2020
Infections caused by Aspergillus species are being increasingly reported. Aspergillus flavus is the second most common species within this genus causing invasive infections in humans, and isolates showing azole resistance have been recently described. A.
Alcazar-Fuoli, Laura, Pelaez, Teresa, Gonzalez-Jimenez, Irene, Alastruey-Izquierdo, Ana, Ana Alastruey-Izquierdo, Olga Rivero-Menendez, Mellado, Emilia, Emilia Mellado, Irene Gonzalez-Jimenez, Teresa Pelaez, Jose Lucio, Rivero-Menendez, Olga, Laura Alcazar-Fuoli, Lucio, Jose   +13 more
core   +1 more source

Genetic analysis of azole-resistant Aspergillus fumigatus isolated from domestic and imported tulip bulbs in Japan

Journal of Global Antimicrobial Resistance
Objective: Azole-resistant Aspergillus fumigatus (ARAF) poses a significant clinical threat and is increasingly being isolated from agricultural environments.
Satomi Uehara, Hiroki Takahashi, Yukari Nishino, Yumi Takahashi, Takashi Chiba, Keiko Yokoyama, Hirofumi Miyake, Kenji Sadamasu, Daisuke Hagiwara   +8 more
doaj   +1 more source

Design, Synthesis of Pyridine Based Thiazolidine Derivatives and Investigation of Antimicrobial Activity Targeting Ergosterol Biosynthesis via In Vitro and In Silico Approaches

Chemical Biology &Drug Design, Volume 108, Issue 1, July 2026.
Synthesis of thiazolidine derivatives and investigation of their antimicrobial activities. ABSTRACT Pyridine and thiazolidine ring systems are unique heterocyclic rings since they are present in the structure of various drug/drug‐like molecules and reported in many studies for their distinct biological effects.
Aybüke Züleyha Kaya, Asaf Evrim Evren, Ülküye Dudu Gül, Halide Edip Temel, Leyla Yurttaş   +4 more
wiley   +1 more source

Reduced Activity of Triazole Antifungal Agents Against Aspergillus tubingensis From a Global Collection of Genomically‐Characterized Aspergillus Section Nigri Clinical Isolates (2020–2023)

Mycoses, Volume 69, Issue 7, July 2026.
ABSTRACT Background The black moulds comprising Aspergillus section Nigri are clinically important organisms causing aspergillosis and otomycosis; triazole (azole) antifungal agents represent the primary prophylaxis and treatment option for these infections.
John H. Kimbrough, Marisa L. Winkler, Maura H. Karr, Jessica M. Ewald, Mariana Castanheira   +4 more
wiley   +1 more source

Examination of cyp51A and cyp51B expression level of the first Polish azole resistant clinical Aspergillus fumigatus isolate [PDF]

, 2015
Aspergillus fumigatus is one of the most prevalent airborne fungal pathogens causing infections worldwide. Most A. fumigatus strains are susceptible to azoles, which are administered as the first line therapeutics.
Kurzyk, Ewelina, Brillowska-Dąbrowska, Anna, Mroczyńska, Martyna, Nawrot, Urszula, Włodarczyk, Katarzyna   +4 more
core   +1 more source

Monitoring fungicide resistance frequencies – a case study of barley net blotch

Pest Management Science, Volume 82, Issue 6, Page 5936-5947, June 2026.
Droplet digital PCR revealed the frequency of alleles associated with decreased sensitivity to demethylation inhibitor (DMI) and succinate dehydrogenase inhibitor (SDHI) fungicides in Pyrenophora teres from barley net blotch in Western Australia. The findings highlight field‐level allele dynamics and emerging risks to fungicide efficacy.
Noel L. Knight, Kul C. Adhikari, Wesley J. Mair, Kejal Dodhia, Katherine G. Zulak, Francisco J. Lopez‐Ruiz   +5 more
wiley   +1 more source