Results 11 to 20 of about 1,765 (165)

Azole Resistance-Associated Regulatory Motifs within the Promoter of cyp51A in Aspergillus fumigatus [PDF]

Microbiology Spectrum, 2022
Aspergillus fumigatus is one of the deadliest fungal species, causing hundreds of thousands of deaths each year. Because azoles provide the preferred first-line option for treatment of aspergillosis, the increase in rates of resistance and the poor ...
Alexander Kühbacher, Mandy Peiffer, Peter Hortschansky, Petra Merschak, Michael J. Bromley, Hubertus Haas, Axel A. Brakhage, Fabio Gsaller   +7 more
doaj   +3 more sources

Azole Resistance and cyp51A Mutation of Aspergillus fumigatus in a Tertiary Referral Hospital in Taiwan

Journal of Fungi, 2022
Azole resistance in Aspergillus fumigatus has increasingly been reported worldwide. Its major mechanism of resistance is mediated by mutations in cyp51A. The objective of this study was to test the antifungal susceptibilities of A.
Tsun-Hao Hsu, Po-Yen Huang, Yun-Chen Fan, Pei-Lun Sun   +3 more
doaj   +3 more sources

Widespread Occurrence of a CYP51A Pseudogene in Calonectria pseudonaviculata [PDF]

Mycobiology, 2020
Calonectria pseudonaviculata and C. henricotiae are two closely related fungal species responsible for boxwood blight disease of ornamental shrubs (Buxus spp.) in the U.S. and Europe.
Stefanos Stravoravdis, Nicholas R. LeBlanc, Robert E. Marra, Jo Anne Crouch, Jonathan P. Hulvey   +4 more
doaj   +3 more sources

An efficient gene targeting system using Δku80 and functional analysis of Cyp51A in Trichophyton rubrum

AMB Express
Trichophyton rubrum is one of the most frequently isolated fungi in patients with dermatophytosis. Despite its clinical significance, the molecular mechanisms of drug resistance and pathogenicity of T.
Masaki Ishii, Tsuyoshi Yamada, Shinya Ohata   +2 more
doaj   +3 more sources

Transcriptomic and metabolomic analysis of a non-cyp51A mutant azole-resistant Aspergillus fumigatus isolated from Ningxia, China [PDF]

Frontiers in Microbiology
BackgroundAzole-resistant A. fumigatus (Aspergillus fumigatus) has been extensively documented both domestically and internationally, with mutations in the cyp51A gene identified as the predominant mechanism of resistance.
Wanting Ma, Yuting Kang, Yuting Kang, Qiujie Li, Pengtao Wang, Wei Jia, Wei Jia   +6 more
doaj   +2 more sources

Non-cyp51A Azole-Resistant Aspergillus fumigatus Isolates with Mutation in HMG-CoA Reductase [PDF]

Emerging Infectious Diseases, 2018
The recent increase in azole-resistant Aspergillus fumigatus is a global concern. Identifying the mutations that confer azole resistance is essential for developing novel methods for prompt diagnosis and effective drug treatment. We screened A. fumigatus
Daisuke Hagiwara, Teppei Arai, Hiroki Takahashi, Yoko Kusuya, Akira Watanabe, Katsuhiko Kamei   +5 more
doaj   +3 more sources

Regulation of Ergosterol Biosynthesis in Pathogenic Fungi: Opportunities for Therapeutic Development [PDF]

Microorganisms
Ergosterol plays a dual role in fungal pathogenesis and azole resistance, driving key advancements in the understanding of its biosynthesis regulation.
Lingyun Song, Sha Wang, Hang Zou, Xiaokang Yi, Shihan Jia, Rongpeng Li, Jinxing Song   +6 more
doaj   +2 more sources

Antifungal Susceptibility and Genotypic Analysis of cyp51A Mutations in Aspergillus fumigatus Isolates in Malaysia

Infection and Drug Resistance
Xue Ting Tan, Nurin Nazirah Binti Mokhtar, Shirley Yi Fen Hii, Fairuz Amran Bacteriology Unit, Infectious Diseases Research Centre, Institute for Medical Research, National Institute of Health, Ministry of Health Malaysia, Setia Alam, Selangor ...
Tan XT, Mokhtar NN, Hii SYF, Amran F
doaj   +4 more sources

Contribution of the CYP51A Y119F Mutation to Azole Resistance in <i>Aspergillus flavus</i>. [PDF]

J Fungi (Basel)
Aspergillus flavus is both an agricultural and clinical pathogen, notable for its ability to contaminate crops with aflatoxins and cause invasive aspergillosis. The increasing emergence of azole resistance in A. flavus poses a serious challenge to food safety and human health.
Zhou Y, Wang Y, Grum-Grzhimaylo AA, Meijer M, Kraak B, Li Z, Houbraken J.   +6 more
europepmc   +5 more sources

Differential Functions of Individual Transcription Factor Binding Sites in the Tandem Repeats Found in Clinically Relevant cyp51A Promoters in Aspergillus fumigatus

mBio, 2022
Aspergillus fumigatus is the major filamentous fungal pathogen in humans. The gold standard treatment of A. fumigatus is based on azole drug use, but the appearance of azole-resistant isolates is increasing at an alarming rate.
Sanjoy Paul, Paul E. Verweij, Willem J. G. Melchers, W. Scott Moye-Rowley   +3 more
doaj   +1 more source