Results 11 to 20 of about 1,046 (126)

Investigation of Azole Resistance Involving cyp51A and cyp51B Genes in Clinical Aspergillus flavus Isolates

Polish Journal of Microbiology
This study aimed to investigate azole resistance mechanisms in Aspergillus flavus, which involve cyp51A and cyp51B genes. Real-time Reverse Transcriptase qPCR method was applied to determine the overexpression of cyp51A and cyp51B genes for 34 A.
Ghorbel Dhoha, Amouri Imen, Khemekhem Nahed, Neji Sourour, Trabelsi Houaida, Elloumi Moez, Sellami Hayet, Makni Fattouma, Ayadi Ali, Hadrich Ines   +9 more
doaj   +2 more sources

Non-cyp51A Azole-Resistant Aspergillus fumigatus Isolates with Mutation in HMG-CoA Reductase [PDF]

Emerging Infectious Diseases, 2018
The recent increase in azole-resistant Aspergillus fumigatus is a global concern. Identifying the mutations that confer azole resistance is essential for developing novel methods for prompt diagnosis and effective drug treatment. We screened A. fumigatus
Daisuke Hagiwara, Teppei Arai, Hiroki Takahashi, Yoko Kusuya, Akira Watanabe, Katsuhiko Kamei   +5 more
doaj   +2 more sources

cyp51A mutations, protein modeling, and efflux pump gene expression reveals multifactorial complexity towards understanding Aspergillus section Nigri azole resistance mechanism

Scientific Reports
Black Aspergillus species are the most common etiological agents of otomycosis, and pulmonary aspergillosis. However, limited data is available on their antifungal susceptibility profiles and associated resistance mechanisms.
Pooja Sen, Mukund Vijay, Himanshu Kamboj, Lovely Gupta, Jata Shankar, Pooja Vijayaraghavan   +5 more
doaj   +2 more sources

Multiple Mutations and Overexpression in the CYP51A and B Genes Lead to Decreased Sensitivity of Venturia effusa to Tebuconazole

Current Issues in Molecular Biology, 2022
Multiple demethylation-inhibiting (DMI) fungicides are used to control pecan scab, caused by Venturia effusa. To compare the efficacy of various DMI fungicides on V.
Logan C. Moore, Timothy B. Brenneman, Sumyya Waliullah, Clive H. Bock, Md Emran Ali   +4 more
doaj   +2 more sources

Direct molecular diagnosis of aspergillosis and CYP51A profiling from respiratory samples of French patients

Frontiers in Microbiology, 2016
Background: Microbiological diagnosis of aspergillosis and triazole resistance is limited by poor culture yield. To better estimate this shortcoming, we compared culture and molecular detection of A.
Yanan Zhao, Cécile Garnaud, Cécile Garnaud, Marie-Pierre Brenier-Pinchart, Marie-Pierre Brenier-Pinchart, Anne Thiébaut-Bertrand, Anne Thiébaut-Bertrand, Christel Saint-Raymond, Boubou Camara, Rebecca Hamidfar-Roy, Odile Cognet, Danièle Maubon, Danièle Maubon, Muriel Cornet, Muriel Cornet, David S Perlin   +15 more
doaj   +2 more sources

Occurrence summary of cyp51A variants by clade.

, 2022
Occurrence summary of cyp51A variants by clade.
Lotus A. Lofgren (9253428), Brandon S. Ross (14135875), Robert A. Cramer (8844023), Jason E. Stajich (6700331)   +3 more
core   +1 more source

Antifungal Susceptibility Tests and the cyp51 Mutant Strains among Clinical Aspergillus fumigatus Isolates from Korean Multicenters

Mycobiology, 2020
We investigated the antifungal susceptibilities and the cyp51 mutant strains among Aspergillus fumigatus clinical isolates obtained from 10 university hospitals in Korea. Of the 84 isolates examined, two itraconazole-resistant isolates were found with no
Eun Jeong Won, Min Young Joo, Dain Lee, Mi-Na Kim, Yeon-Joon Park, Soo Hyun Kim, Myung Geun Shin, Jong Hee Shin   +7 more
doaj   +1 more source

Interrogation of related clinical pan-azole-resistant Aspergillus fumigatus strains: G138C, Y431C, and G434C single nucleotide polymorphisms in cyp51A, upregulation of cyp51A, and integration and activation of transposon Atf1 in the cyp51A promoter [PDF]

, 2011
Multiple Aspergillus fumigatus isolates from a patient with two aspergillomas complicating chronic pulmonary aspergillosis were pan-azole resistant.
Robson, GD, Peter A. Warn, Denning, David; id_orcid, Robson, G.D., Susan J. Howard, Robson, Geoffrey, Howard, Susan, Warn, P.A., Howard, S.J., Sanglard, D, Denning, D.W., Michael J. Anderson, Warn, Peter, Dominique Sanglard, Sanglard, D., Albarrag, AM, Warn, PA, Ahmed M. Albarrag, Albarrag, A.M., Denning, DW.; id_orcid, Anderson, MJ, Howard, SJ, Geoff D. Robson, Sanglard, Dominique, Anderson, Michael, David W. Denning, Albarrag, Ahmed M., Anderson, M.J.   +27 more
core   +1 more source

A 23 bp cyp51A Promoter Deletion Associated With Voriconazole Resistance in Clinical and Environmental Isolates of Neocosmospora keratoplastica

Frontiers in Microbiology, 2020
In the fungal pathogen Aspergillus fumigatus, resistance to azole antifungals is often linked to mutations in CYP51A, a gene that encodes the azole antifungal drug target lanosterol 14α-demethylase.
Jasper Elvin James, Erwin Lamping, Jacinta Santhanam, Trudy Jane Milne, Mohd Fuat Abd Razak, Latiffah Zakaria, Richard David Cannon   +6 more
doaj   +1 more source

A new Aspergillus fumigatus resistance mechanism conferring in vitro cross-resistance to azole antifungals involves a combination of cyp51A alterations. [PDF]

, 2007
Contains fulltext : 52396.pdf (Publisher’s version ) (Open Access)Fourteen Aspergillus fumigatus clinical isolates that exhibited a pattern of reduced susceptibility to triazole drugs were analyzed. The sequences of the cyp51A gene from
Alcazar-Fuoli, L., Mellado, E., Melchers, W.J.G., Rodriguez-Tudela, J.L., Garcia-Effron, G., Verweij, P.E., Cuenca-Estrella, M.   +6 more
core   +2 more sources