Results 31 to 40 of about 15,578 (196)

Azole Resistance in Aspergillus fumigatus: A Five-Year Follow Up Experience in a Tertiary Hospital With a Special Focus on Cystic Fibrosis

Frontiers in Cellular and Infection Microbiology, 2021
Azole-resistant Aspergillus fumigatus (ARAf) has emerged worldwide during the last decades. Drug pressure after long term treatments of chronically infected patients and the propagation of environmental clones selected under the pressure of imidazoles ...
Hélène Guegan, Hélène Guegan, Emilie Prat, Florence Robert-Gangneux, Florence Robert-Gangneux, Jean-Pierre Gangneux, Jean-Pierre Gangneux   +6 more
doaj   +1 more source

Resistance of Candida to azoles and echinocandins worldwide [PDF]

Clinical Microbiology and Infection, 2019
Recently there has been an increase in Candida infections worldwide. A handful of species in the genus Candida are opportunistic pathogens and have been known to cause infections in immunocompromised or otherwise impaired hosts. These infections can be superficial, affecting the skin or mucous membrane, or invasive, which can be life-threatening ...
K E, Pristov, M A, Ghannoum
openaire   +2 more sources

Borylcyclopropanes: Synthetic Strategies and Applications

Angewandte Chemie, EarlyView.
Borylcyclopropanes (cyclopropanes bearing a boron substituent) sit at the intersection of two privileged frameworks in synthesis. This review provides the first exhaustive survey of their chemistry, spanning metal–carbene, nucleophilic cyclization, radical, hydroboration, and C─H activation routes, and documenting applications in medicinal chemistry ...
Aiza A. Butt, Joseph M. Ready
wiley   +2 more sources

Non-cyp51A Azole-Resistant Aspergillus fumigatus Isolates with Mutation in HMG-CoA Reductase

Emerging Infectious Diseases, 2018
The recent increase in azole-resistant Aspergillus fumigatus is a global concern. Identifying the mutations that confer azole resistance is essential for developing novel methods for prompt diagnosis and effective drug treatment. We screened A. fumigatus
Daisuke Hagiwara, Teppei Arai, Hiroki Takahashi, Yoko Kusuya, Akira Watanabe, Katsuhiko Kamei   +5 more
doaj   +1 more source

Azole-ResistantAspergillus fumigatus, Iran

Emerging Infectious Diseases, 2013
To the Editor: Aspergillus fumigatus causes a variety of diseases in humans. The drugs recommended for treatment of Aspergillus diseases are the mold-active azole antifungal drugs (1). However, a wide range of mutations in A. fumigatus confer azole resistance, which commonly involves modifications in the cyp51A gene (2), the target for azole antifungal
Seyedmousavi, S., Hashemi, S.J., Zibafar, E., Zoll, J., Hedayati, M.T., Mouton, J.W., Melchers, W.J.G., Verweij, P.E.   +7 more
openaire   +5 more sources

Azole susceptibility and resistance in Candida dubliniensis [PDF]

Biochemical Society Transactions, 2005
Candida dubliniensis is a recently described species of pathogenic yeast that shares many phenotypic features with Candida albicans. It is primarily associated with oral colonization and infection in HIV-infected individuals. Isolates of C. dubliniensis are generally susceptible to commonly used azole antifungal agents; however, resistance has been ...
E, Pinjon, G P, Moran, D C, Coleman, D J, Sullivan   +3 more
openaire   +2 more sources

Triazole Resistance in Aspergillus spp.: A Worldwide Problem?

Journal of Fungi, 2016
Since the first description of an azole-resistant A. fumigatus strain in 1997, there has been an increasing number of papers describing the emergence of azole resistance.
Olga Rivero-Menendez, Ana Alastruey-Izquierdo, Emilia Mellado, Manuel Cuenca-Estrella   +3 more
doaj   +1 more source

Azole Cross-Resistance in Aspergillus fumigatus [PDF]

Antimicrobial Agents and Chemotherapy, 2002
ABSTRACT We susceptibility tested 17 clinical isolates of Aspergillus fumigatus , for most of which MICs of itraconazole were elevated (MIC at which 50% of the isolates tested are inhibited, 16 μg/ml), against itraconazole, posaconazole, ravuconazole, and voriconazole.
Mosquera, J., Denning, D.W.; id_orcid 0000-0001-5626-2251   +1 more
openaire   +3 more sources

Environmental Hotspots for Azole Resistance Selection of Aspergillus fumigatus, the Netherlands

Emerging Infectious Diseases, 2019
Azole resistance is a major concern for treatment of infections with Aspergillus fumigatus. Environmental resistance selection is a main route for Aspergillus spp. to acquire azole resistance.
Sijmen E. Schoustra, Alfons J.M. Debets, Antonius J.M.M. Rijs, Jianhua Zhang, Eveline Snelders, Peter C. Leendertse, Willem J.G. Melchers, Anton G. Rietveld, Bas J. Zwaan, Paul E. Verweij   +9 more
doaj   +1 more source

In Candida glabrata, ERMES Component GEM1 Controls Mitochondrial Morphology, mtROS, and Drug Efflux Pump Expression, Resulting in Azole Susceptibility

Journal of Fungi, 2023
Mitochondrial dysfunction or morphological abnormalities in human pathogenic fungi are known to contribute to azole resistance; however, the underlying molecular mechanisms are unknown.
Michiyo Okamoto, Keiko Nakano, Azusa Takahashi-Nakaguchi, Kaname Sasamoto, Masashi Yamaguchi, Miguel Cacho Teixeira, Hiroji Chibana   +6 more
doaj   +1 more source