Results 21 to 30 of about 15,578 (196)

Differentially Regulated Transcription Factors and ABC Transporters in a Mitochondrial Dynamics Mutant Can Alter Azole Susceptibility of Aspergillus fumigatus

Frontiers in Microbiology, 2020
Azole resistance of the fungal pathogen Aspergillus fumigatus is an emerging problem. To identify novel mechanisms that could mediate azole resistance in A.
Laura Sturm, Bernadette Geißel, Ronny Martin, Ronny Martin, Johannes Wagener, Johannes Wagener, Johannes Wagener   +6 more
doaj   +1 more source

Molecular mechanisms of azole resistance in fungi [PDF]

FEMS Microbiology Letters, 2006
This paper reviews the current status of our understanding of azole antifungal resistance mechanisms at the molecular level and explores their implications. Extensive biochemical studies have highlighted a significant diversity in mechanisms conferring resistance to azoles, which include alterations in sterol biosynthesis, target site, uptake and ...
T, Joseph-Horne, D W, Hollomon
openaire   +2 more sources

Multiple mechanisms contribute to the development of clinically significant azole resistance in Aspergillus fumigatus

Frontiers in Microbiology, 2015
Infections caused by the filamentous fungus Aspergillus fumigatus are a significant clinical issue and represent the second most-common form of fungal infection. Azole drugs are effective against this pathogen but resistant isolates are being found more
Scott eMoye-Rowley
doaj   +1 more source

Paradoxal Trends in Azole-Resistant Aspergillus fumigatus in a National Multicenter Surveillance Program, the Netherlands, 2013–2018

Emerging Infectious Diseases, 2020
We investigated the prevalence of azole resistance of Aspergillus fumigatus isolates in the Netherlands by screening clinical A. fumigatus isolates for azole resistance during 2013–2018.
Pieter P.A. Lestrade, Jochem B. Buil, Martha T. van der Beek, Ed J. Kuijper, Karin van Dijk, Greetje A. Kampinga, Bart J.A. Rijnders, Alieke G. Vonk, Sabine C. de Greeff, Annelot F. Schoffelen, Jaap van Dissel, Jacques F. Meis, Willem J.G. Melchers, Paul E. Verweij   +13 more
doaj   +1 more source

Loss of Upc2p-Inducible ERG3 Transcription Is Sufficient To Confer Niche-Specific Azole Resistance without Compromising Candida albicans Pathogenicity

mBio, 2018
Inactivation of sterol Δ5,6-desaturase (Erg3p) in the prevalent fungal pathogen Candida albicans is one of several mechanisms that can confer resistance to the azole antifungal drugs.
Arturo Luna-Tapia, Hubertine M. E. Willems, Josie E. Parker, Hélène Tournu, Katherine S. Barker, Andrew T. Nishimoto, P. David Rogers, Steven L. Kelly, Brian M. Peters, Glen E. Palmer   +9 more
doaj   +1 more source

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

Determination of the Prevalence of Triazole Resistance in Environmental Aspergillus fumigatus Strains Isolated in South Wales, UK

Frontiers in Microbiology, 2018
Background/Objectives: Azole resistance in Aspergillus fumigatus associated with the TR34/L98H mutations in the cyp51A gene have been increasingly reported.
Alexandra Tsitsopoulou, Raquel Posso, Lorna Vale, Scarlett Bebb, Elizabeth Johnson, P. L. White   +5 more
doaj   +1 more source

Mitochondria-Mediated Azole Drug Resistance and Fungal Pathogenicity: Opportunities for Therapeutic Development

Microorganisms, 2020
In recent years, the role of mitochondria in pathogenic fungi in terms of azole resistance and fungal pathogenicity has been a rapidly developing field. In this review, we describe the molecular mechanisms by which mitochondria are involved in regulating
Jinxing Song, Jingwen Zhou, Lei Zhang, Rongpeng Li   +3 more
doaj   +1 more source

Metabolomic profiling for the identification of potential biomarkers involved in a laboratory azole resistance in Candida albicans. [PDF]

PLoS ONE, 2018
Candida albicans, one of the most common fungal pathogens, is responsible for several yeast infections in human hosts, being resistant to classically used antifungal drugs, such as azole drugs. Multifactorial and multistep alterations are involved in the
Ling Li, ZeBin Liao, Yu Yang, Lei Lv, YingYing Cao, ZhenYu Zhu   +5 more
doaj   +1 more source

Acquired multi-azole resistance in Candida tropicalis during persistent urinary tract infection in a dog

Medical Mycology Case Reports, 2016
Multi-azole resistance acquisition by Candida tropicalis after prolonged antifungal therapy in a dog with urinary candidiasis is reported. Pre- and post-azole treatment isolates were clonally related and had identical silent mutations in the ERG11 gene ...
Sergio Álvarez-Pérez, Marta E. García, María Teresa Cutuli, María Luisa Fermín, María Ángeles Daza, Teresa Peláez, José L. Blanco   +6 more
doaj   +1 more source