Results 41 to 50 of about 15,578 (196)
The Lipid Composition of Azole-sensitive and Azole-resistant Strains of Candida albicans [PDF]
Microbiology, 1986 The lipid compositions of two azole-sensitive (A and B2630) and two azole-resistant (AD and KB) strains of the opportunistic fungal pathogen Candida albicans were studied by using several lipid extraction procedures: no differences were observed between the lipid content or total phospholipid/neutral lipid ratios of the four strains.
C A, Hitchcock +2 more
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Azole‐Resistant Central Nervous System Aspergillosis [PDF]
Clinical Infectious Diseases, 2009 Three patients with central nervous system aspergillosis due to azole-resistant Aspergillus fumigatus (associated with a leucine substitution for histidine at codon 98 [L98H] and a 34-base pair repeat in tandem in the promoter region) are described. The patients were treated with combination therapy or with polyenes, but all patients died.
Linden, J.W.M. van der +7 more
openaire +4 more sources
Mitochondrial Complex I Is a Global Regulator of Secondary Metabolism, Virulence and Azole Sensitivity in Fungi. [PDF]
PLoS ONE, 2016 Recent estimates of the global burden of fungal disease suggest that that their incidence has been drastically underestimated and that mortality may rival that of malaria or tuberculosis.
Mike Bromley +11 more
doaj +1 more source
Aneuploidy Is Associated with Azole Resistance in Aspergillus fumigatus
Antimicrobial Agents and Chemotherapy, 2023 Azole resistance in Aspergillus fumigatus is on the rise. Nontarget-mediated mechanisms are a common cause of azole resistance in chronic pulmonary aspergillosis (CPA).
Aiah Khateb +4 more
openaire +3 more sources
Gain of function mutations in CgPDR1 of Candida glabrata not only mediate antifungal resistance but also enhance virulence. [PDF]
PLoS Pathogens, 2009 CgPdr1p is a Candida glabrata Zn(2)-Cys(6) transcription factor involved in the regulation of the ABC-transporter genes CgCDR1, CgCDR2, and CgSNQ2, which are mediators of azole resistance.
Sélène Ferrari +9 more
doaj +1 more source
Azole Resistance in Candida Yeasts
Chemické listy, 2022 Systemic fungal diseases and antifungal resistance represent a serious problem in human medicine and contribute to increased patient mortality. The most common causes of these diseases are opportunistic yeasts of the genus Candida. C. albicans is considered to be the main pathogen, together with C. glabrata, C. tropicalis, C.
Zuzana Malinovská +3 more
openaire +1 more source
Advanced Science, EarlyView.Caspofungin heteroresistance is prevalent in clinical Candida glabrata isolates and depends on calcineurin‐mediated stress adaptation. This transient phenotype serves as a reservoir for resistance evolution, enabling the emergence of stable resistant descendants under prolonged drug pressure.
Yanyu Su +7 more
wiley +1 more source
Journal of Fungi, 2020 Aspergillosis due to azole-resistant Aspergillus fumigatus is a worldwide problem with major therapeutic implications. In patients with invasive aspergillosis, a low yield of fungal cultures results in underestimation of azole resistance. To detect azole
Ashutosh Singh +4 more
doaj +1 more source
Journal of Fungi, 2017 Azole resistance in Aspergillus has emerged as an escalating problem in health care, and it has been detected in patients exposed, or not, to these drugs.
Sarah Santos Gonçalves
doaj +1 more source
PLoS Pathogens, 2021 Aspergillus fumigatus is an opportunistic human pathogen that causes aspergillosis, a spectrum of environmentally acquired respiratory illnesses. It has a cosmopolitan distribution and exists in the environment as a saprotroph on decaying plant matter ...
Caroline Burks +4 more
doaj +1 more source