Results 61 to 70 of about 16,315 (211)

The role of azoles in the management of azole-resistant aspergillosis: From the bench to the bedside

Drug Resistance Updates, 2014
Azole resistance is an emerging problem in Aspergillus fumigatus and is associated with a high probability of treatment failure. An azole resistance mechanism typically decreases the activity of multiple azole compounds, depending on the mutation. As alternative treatment options are limited and in some isolates the minimum inhibitory concentration ...
Seyedmousavi, S., Mouton, J.W., Melchers, W.J., Bruggemann, R.J.M., Verweij, P.E.   +4 more
openaire   +3 more sources

Epidemiological and genomic landscape of azole resistance mechanisms in Aspergillus fungi

Frontiers in Microbiology, 2016
Invasive aspergillosis is a life-threatening mycosis caused by the pathogenic fungus Aspergillus. The predominant causal species is Aspergillus fumigatus, and azole drugs are the treatment of choice.
Daisuke Hagiwara, Akira Watanabe, Katsuhiko Kamei, Gustavo Henrique Goldman   +3 more
doaj   +1 more source

Synthesis of β‐ and γ‐Carbolinones Through a Fe(III)‐Mediated Radical 6‐Endo‐Trig Cyclization of Indole‐Based Ugi 4‐CR Adducts

European Journal of Organic Chemistry, EarlyView.
A practical strategy for synthesizing β‐ and γ‐carbolinones from indole‐based Ugi 4‐CR adducts through an intramolecular radical cyclization using Fe(III)–H species is presented. This approach enables the efficient synthesis of spiro‐carbolinones under mild reaction conditions and demonstrates the effectiveness of secondary radicals in both cyclization
María F. Olvera‐Granados, Luis A. Polindara‐García   +1 more
wiley   +1 more source

Clonal expansion and emergence of environmental multiple-triazole-resistant Aspergillus fumigatus strains carrying the TR₃₄/L98H mutations in the cyp51A gene in India. [PDF]

PLoS ONE, 2012
Azole resistance is an emerging problem in Aspergillus which impacts the management of aspergillosis. Here in we report the emergence and clonal spread of resistance to triazoles in environmental Aspergillus fumigatus isolates in India. A total of 44 (7%)
Anuradha Chowdhary, Shallu Kathuria, Jianping Xu, Cheshta Sharma, Gandhi Sundar, Pradeep Kumar Singh, Shailendra N Gaur, Ferry Hagen, Corné H Klaassen, Jacques F Meis   +9 more
doaj   +1 more source

Prediction of Prion Proteins in E. coli Based on Bimodal Sequence Characteristics

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Prions are infectious proteins that bear misfolded conformations capable of converting folded states into misfolded aggregates under physiologically relevant conditions. In mammals, prions cause deadly maladies including Creutzfeldt‐Jakob and chronic wasting disease. To date, several prion proteins have been identified in eukaryotes, primarily
Katherine Shreeve, Jinoh Jang, Mridula Srivathsan, Siyu Li, Taylor D. Scott, Silvia Cavagnero   +5 more
wiley   +1 more source

Sensitivity of Irish Pyrenopeziza brassicae populations to methyl benzimidazole carbamate (MBC), quinone outside inhibitor (QoI) and succinate dehydrogenase inhibitor (SDHI) fungicides

Pest Management Science, EarlyView.
For three collections of Irish Pyrenopeziza brassicae populations fungicide sensitivity status to methyl benzimidazole carbamate (MBC), quinone outside inhibitor (QoI) and succinate dehydrogenase inhibitor (SDHI) fungicides was determined using sensitivity screening in vitro. Molecular mechanisms of insensitivity have been identified for MBC and QoI in
Diana E Bucur, Yong‐Ju Huang, Bruce DL Fitt, Steven Kildea   +3 more
wiley   +1 more source

Disease control in oilseed rape: Current insights and perspectives for next‐generation integrated pest management

Pest Management Science, EarlyView.
Winter oilseed rape in Europe suffers frequent pathogen losses. This review outlines key integrated pest management (IPM) strategies, rotation, residue and tillage management, optimized sowing, resistance, and targeted fungicides supported by forecasting.
Jon S West, Małgorzata Jędryczka, Nazanin Zamani‐Noor   +2 more
wiley   +1 more source

Absorption and translocation of 14C‐propiconazole associated with two adjuvants in young coffee plants

Pest Management Science, EarlyView.
Experimental workflow evaluating 14C‐propiconazole absorption and translocation in Coffea arabica with two biodegradable adjuvants, quantified at six post‐application time points using radioscanner and liquid scintillation spectrometry. Abstract BACKGROUND This study evaluated the absorption, translocation and distribution of 14C‐propiconazole applied ...
Valéria de Souza Ivo, Emerson Leite, José Mak, Valdemar Luiz Tornisielo, Kassio Ferreira Mendes   +4 more
wiley   +1 more source

High-Level Pan-Azole-Resistant Aspergillosis [PDF]

Journal of Clinical Microbiology, 2015
ABSTRACT High-level pan-azole-resistant Aspergillus fumigatus was recovered from four patients with chronic lung disease. In one patient, the development of progressive resistance followed long-term azole therapy and switching between antifungal azoles.
Ingen, J. van, Lee, H.A.L. van der, Rijs, A.J.M.M., Snelders, E., Melchers, W.J.G., Verweij, P.E.   +5 more
openaire   +3 more sources

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source