Results 1 to 10 of about 33,379 (274)

High incidence of azole resistance among Candida albicans and C. glabrata isolates in Northeastern Iran [PDF]

Current Medical Mycology, 2021
Background and Purpose: Resistance to antifungal drugs is increasing among Candida isolates from patients with vulvovaginal candidiasis (VVC). Lack of correct diagnosis of Candida causing VVC and the experimental use of antifungal drugs are the main ...
Hossein Zarrinfar, Zahra Kord, Abdolmajid Fata   +2 more
doaj   +1 more source

Coordinated Regulation of Membrane Homeostasis and Drug Accumulation by Novel Kinase STK-17 in Response to Antifungal Azole Treatment

Microbiology Spectrum, 2022
The emergence of antifungal resistance, especially to the most widely used azole class of ergosterol biosynthesis inhibitors, makes fungal infections difficult to treat in clinics and agriculture. When exposed to azoles, fungi can make adaptive responses
Chengcheng Hu, Mi Zhou, Xianhe Cao, Wei Xue, Zhenying Zhang, Shaojie Li, Xianyun Sun   +6 more
doaj   +1 more source

Trichophyton: Changing nomenclature and practical implications

Indian Journal of Dermatology, 2023
Trichophyton interdigitale had been regarded as anthropophilic, mainly causing non-inflammatory tinea unguium and tinea pedis. T. mentagrophytes, thought to be zoophilic, were regarded as responsible for more inflammatory dermatophytosis.
Manas Chatterjee, Debatri Datta
doaj   +1 more source

High-Throughput Chemical Screen Identifies a 2,5-Disubstituted Pyridine as an Inhibitor of Candida albicans Erg11

mSphere, 2022
Fungal infections contribute to over 1.5 million deaths annually, with Candida albicans representing one of the most concerning human fungal pathogens. While normally commensal in nature, compromise of host immunity can result in C.
Antonia C. Du Bois, Alice Xue, Chester Pham, Nicole M. Revie, Kirsten J. Meyer, Yoko Yashiroda, Charles Boone, Justin R. Nodwell, Peter Stogios, Alexei Savchenko, Nicole Robbins, Kali R. Iyer, Leah E. Cowen   +12 more
doaj   +1 more source

Case Report: Hypercalcemia as a manifestation of acute adrenal crisis precipitated by fluconazole use, and a review of the literature

Frontiers in Endocrinology, 2023
Acute adrenal crisis classically presents with vomiting, altered sensorium, and hypotension. We describe a unique case manifesting with severe hypercalcemia. Addisonian crisis was unusually precipitated by fluconazole use.
Kuan Swen Choo, Jielin Yew, Eberta Jun Hui Tan, Troy Hai Kiat Puar   +3 more
doaj   +1 more source

Antifungal Activity of Minocycline and Azoles Against Fluconazole-Resistant Candida Species

Frontiers in Microbiology, 2021
Candida species are the most common fungal pathogens to infect humans, and can cause life-threatening illnesses in individuals with compromised immune systems.
Jingwen Tan, Shaojie Jiang, Lihua Tan, Haiyan Shi, Lianjuan Yang, Yi Sun, Xiuli Wang   +6 more
doaj   +1 more source

Oceanapiside, a Marine Natural Product, Targets the Sphingolipid Pathway of Fluconazole-Resistant Candida glabrata

Marine Drugs, 2021
Oceanapiside (OPS), a marine natural product with a novel bifunctional sphingolipid structure, is fungicidal against fluconazole-resistant Candida glabrata at 10 μg/mL (15.4 μM).
Doralyn S. Dalisay, Evan W. Rogers, Tadeusz F. Molinski   +2 more
doaj   +1 more source

Magnetic nanoparticle - indium phthalocyanine conjugate embedded in electrospun fiber for photodynamic antimicrobial chemotherapy and photodegradation of methyl red

Heliyon, 2019
ClIn(III) octacarboxy phthalocyanine (ClInOCPc) when alone or conjugated to magnetic nanoparticles (MNP-ClInOCPc) was employed for both photodynamic antimicrobial chemotherapy of an unknown water sample and Staphylococcus aureus, and for photo ...
Azole Sindelo, Tebello Nyokong
doaj   +1 more source

Synthesis of Novel Thiazole Derivatives Bearing β-Amino Acid and Aromatic Moieties as Promising Scaffolds for the Development of New Antibacterial and Antifungal Candidates Targeting Multidrug-Resistant Pathogens

Molecules, 2021
Rapidly growing antimicrobial resistance among clinically important bacterial and fungal pathogens accounts for high morbidity and mortality worldwide.
Dovilė Malūkaitė, Birutė Grybaitė, Rita Vaickelionienė, Giedrius Vaickelionis, Birutė Sapijanskaitė-Banevič, Povilas Kavaliauskas, Vytautas Mickevičius   +6 more
doaj   +1 more source

CYP51 Mutations in the Fusarium solani Species Complex: First Clue to Understand the Low Susceptibility to Azoles of the Genus Fusarium

Journal of Fungi, 2022
Members of Fusarium solani species complex (FSSC) are cosmopolitan filamentous fungi responsible for invasive fungal infections in immunocompromised patients.
Pierre Vermeulen, Arnaud Gruez, Anne-Lyse Babin, Jean-Pol Frippiat, Marie Machouart, Anne Debourgogne   +5 more
doaj   +1 more source