Results 11 to 20 of about 33,379 (274)

Azole-resistant aspergillosis

Journal of Infection, 2015
Azole-resistance in Aspergillus fumigatus is emerging and is becoming an increasing problem in the management of aspergillosis. Two types of development of resistance have been described; resistance acquired during azole treatment in an individual patient and through environmental exposure to fungicides. The main molecular mechanism of azole resistance
Warris, A.
openaire   +3 more sources

ABC transporters and azole susceptibility in laboratory strains of the wheat pathogen Mycosphearella graminicola [PDF]

, 2002
Laboratory strains of Mycosphaerella graminicola with decreased susceptibilities to the azole antifungal agent cyproconazole showed a multidrug resistance phenotype by exhibiting cross-resistance to an unrelated chemical, cycloheximide or rhodamine 6G ...
Nistelrooy, J.G.M., Van, Zwiers, L.H., Stergiopoulos, I., Waard, M.A., De   +3 more
core   +1 more source

Possible environmental origin of resistance of Aspergillus fumigatus to medical triazoles. [PDF]

, 2009
Contains fulltext : 81920.pdf (Publisher’s version ) (Open Access)We reported the emergence of resistance to medical triazoles of Aspergillus fumigatus isolates from patients with invasive aspergillosis.
Snelders, Eveline, Melchers, W.J.G., Rijs, Anthonius J. M. M., A. J. M. M. Rijs, Veld, R., G. H. J. Kema, Verweij, P.E., Melchers, Willem J. G., Snelders, E., Kema, G.H.J., W. J. G. Melchers, Kema, G.H., Verweij, Paul E., E. Snelders, Rijs, A., Rijs, A.J.M.M., Huis In 't Veld, Robert A. G., Huis In 't Veld, R.A., P. E. Verweij, Kema, Gert H. J., R. A. G. Huis in 't Veld   +20 more
core   +2 more sources

Constraints on the evolution of azole resistance in plant pathogenic fungi [PDF]

, 2013
The durability of azole fungicides in controlling agriculturally important pathogenic fungi is unique amongst modern single site fungicides. Today, azoles are still relied on to control pathogens of many crops including cereals, fruits and vegetables ...
Hawkins, N. J., Fraaije, B. A., Cools, H. J.   +2 more
core   +1 more source

Azole-Induced Color Vision Deficiency Associated with Thyroid Hormone Signaling: An Integrated In Vivo, In Vitro, and In Silico Study

, 2022
Azoles that are used in pesticides, pharmaceuticals, and personal care products can have toxic effects on fish. However, there is no information regarding azole-induced visual disorder associated with thyroid disruption.
Xiao-Liang Liao (11805009), Zongwei Cai (631593), Si-Qi Lu (7820489), Zhi-Feng Chen (1940347), Zhi-Cheng Lin (7969319), Xiao-Fan Chen (6722741), Zenghua Qi (775227)   +6 more
core   +1 more source

Accessing diverse azole carboxylic acid building blocks via mild C-H carboxylation: Parallel, one-pot amide couplings and ML-guided substrate scope design [PDF]

, 2022
This manuscript describes a mild, functional group tolerant, and metal-free C-H carboxylation that enables direct access to azole-2-carboxylic acids, followed by amide couplings in one pot.
Michael, Shevlin, Mark, Weisel, Marion H., Emmert, Cyndi Q., He, Stephanie, Felten   +4 more
core   +1 more source

Fungal Resistance to Echinocandins and the MDR Phenomenon in Candida glabrata

Journal of Fungi, 2018
Candida glabrata has thoroughly adapted to successfully colonize human mucosal membranes and survive in vivo pressures. prior to and during antifungal treatment. Out of all the medically relevant Candida species, C.
Kelley R. Healey, David S. Perlin
doaj   +1 more source

Uncovering New Mutations Conferring Azole Resistance in the Aspergillus fumigatus cyp51A Gene

Frontiers in Microbiology, 2020
The opportunistic pathogen Aspergillus fumigatus has developed worldwide resistance to azoles largely through mutations in cytochromeP450 enzyme Cyp51.
Peiying Chen, Musang Liu, Musang Liu, Qiuqiong Zeng, Zheng Zhang, Weida Liu, Weida Liu, Hong Sang, Ling Lu   +8 more
doaj   +1 more source

Biochemical Identification of a Nuclear Coactivator Protein Required for AtrR-Dependent Gene Regulation in Aspergillus fumigatus

mSphere, 2022
Azole drugs represent the primary means of treating infections associated with the filamentous fungal pathogen Aspergillus fumigatus. A central player in azole resistance is the Zn2Cys6 zinc cluster-containing transcription factor AtrR.
Sanjoy Paul, Shivani Ror, W. Hayes McDonald, W. Scott Moye-Rowley   +3 more
doaj   +1 more source

The Crystal and Molecular Structure of (2Z)-2-[3-(4-Methoxybenzoyl)-4,4-dimethyl-1,2-oxazolidin-2-ylidene]-1-(4-methoxyphenyl)ethanone

Crystals, 2011
The crystal and molecular structure of the title compound, viz., (2Z)-2-[3-(4-methoxybenzoyl)-4,4-dimethyl-1,2,-oxazolidin-2-ylidene]-1-(4-methoxyphenyl)ethanone (4), is reported.
Robert A. Gossage, Alan J. Lough, Douglas G. Vaughan, Anna Petrov, Roderick C. Jones   +4 more
doaj   +1 more source