Results 11 to 20 of about 30,366 (254)

Azole-Induced Color Vision Deficiency Associated with Thyroid Hormone Signaling: An Integrated In Vivo, In Vitro, and In Silico Study [PDF]

, 2022
Azoles that are used in pesticides, pharmaceuticals, and personal care products can have toxic effects on fish. However, there is no information regarding azole-induced visual disorder associated with thyroid disruption.
Xiao-Liang Liao (11805009), Zongwei Cai (631593), Si-Qi Lu (7820489), Zhi-Feng Chen (1940347), Zhi-Cheng Lin (7969319), Xiao-Fan Chen (6722741), Zenghua Qi (775227)   +6 more
core   +1 more source

Impact of TR₃₄/L98H, TR₄₆/Y121F/T289A and TR₅₃ Alterations in Azole-Resistant Aspergillus fumigatus on Sterol Composition and Modifications after In Vitro Exposure to Itraconazole and Voriconazole

Microorganisms, 2022
Background: Sterols are the main components of fungal membranes. Inhibiting their biosynthesis is the mode of action of azole antifungal drugs that are widely used to treat fungal disease including aspergillosis.
Rose-Anne Lavergne, Marjorie Albassier, Jean-Benoît Hardouin, Carlos Alvarez-Moreno, Fabrice Pagniez, Florent Morio, Patrice Le Pape, Isabelle Ourliac-Garnier   +7 more
doaj   +1 more source

[Final accepted version, unedited] Understanding the Environmental Drivers of Clinical Azole Resistance in Aspergillus Spp.

Drug Target Insights, 2022
Aspergilli are ubiquitous fungal pathogens associated with several life-threatening infections, especially in immunocompromised patients. Azoles are the first line of treatment for most Aspergillus related infections.
Pooja Sen, Mukund Vijay, Shweta Singh, Saif Hameed, Pooja Vijayaraghvan   +4 more
doaj   +1 more source

Magnetic nanoparticle - indium phthalocyanine conjugate embedded in electrospun fiber for photodynamic antimicrobial chemotherapy and photodegradation of methyl red

Heliyon, 2019
ClIn(III) octacarboxy phthalocyanine (ClInOCPc) when alone or conjugated to magnetic nanoparticles (MNP-ClInOCPc) was employed for both photodynamic antimicrobial chemotherapy of an unknown water sample and Staphylococcus aureus, and for photo ...
Azole Sindelo, Tebello Nyokong
doaj   +1 more source

ABC transporters and azole susceptibility in laboratory strains of the wheat pathogen Mycosphearella graminicola [PDF]

, 2002
Laboratory strains of Mycosphaerella graminicola with decreased susceptibilities to the azole antifungal agent cyproconazole showed a multidrug resistance phenotype by exhibiting cross-resistance to an unrelated chemical, cycloheximide or rhodamine 6G ...
Nistelrooy, J.G.M., Van, Zwiers, L.H., Stergiopoulos, I., Waard, M.A., De   +3 more
core   +1 more source

Possible environmental origin of resistance of Aspergillus fumigatus to medical triazoles. [PDF]

, 2009
Contains fulltext : 81920.pdf (Publisher’s version ) (Open Access)We reported the emergence of resistance to medical triazoles of Aspergillus fumigatus isolates from patients with invasive aspergillosis.
Snelders, Eveline, Melchers, W.J.G., Rijs, Anthonius J. M. M., A. J. M. M. Rijs, Veld, R., G. H. J. Kema, Verweij, P.E., Melchers, Willem J. G., Snelders, E., Kema, G.H.J., W. J. G. Melchers, Kema, G.H., Verweij, Paul E., E. Snelders, Rijs, A., Rijs, A.J.M.M., Huis In 't Veld, Robert A. G., Huis In 't Veld, R.A., P. E. Verweij, Kema, Gert H. J., R. A. G. Huis in 't Veld   +20 more
core   +1 more source

Selectivity improvement of an azole inhibitor of CYP707A by replacing the monosubstituted azole with a disubstituted azole

Bioorganic & Medicinal Chemistry Letters, 2010
The plant growth-retardant uniconazole (UNI), a triazole inhibitor of gibberellin biosynthetic enzyme (CYP701A), inhibits multiple P450 enzymes including ABA 8'-hydroxylase (CYP707A), a key enzyme in ABA catabolism. Azole P450 inhibitors bind to a P450 active site by both coordinating to the heme-iron atom via sp2 nitrogen and interacting with ...
Yasushi, Todoroki, Kumi, Naiki, Hikaru, Aoyama, Minaho, Shirakura, Kotomi, Ueno, Masaharu, Mizutani, Nobuhiro, Hirai   +6 more
openaire   +2 more sources

Constraints on the evolution of azole resistance in plant pathogenic fungi [PDF]

, 2013
The durability of azole fungicides in controlling agriculturally important pathogenic fungi is unique amongst modern single site fungicides. Today, azoles are still relied on to control pathogens of many crops including cereals, fruits and vegetables ...
Hawkins, N. J., Fraaije, B. A., Cools, H. J.   +2 more
core   +1 more source

Surveillance for azole resistance in clinical and environmental isolates of Aspergillus fumigatus in Australia and cyp51A homology modelling of azole-resistant isolates [PDF]

, 2018
Background: The prevalence of azole resistance in Aspergillus fumigatus is uncertain in Australia. Azole exposure may select for resistance. We investigated the frequency of azole resistance in a large number of clinical and environmental isolates ...
Park, R., Park, Robert F, Lopez-Ruiz, Francisco J, Louise Cooley, Chen, Sharon C-A, Robert F Park, Talbot, J., Cooley, L., Harper, Lincoln, Barrs, Vanessa R, Lopez-Ruiz, Fran, William S Cuddy, Harper, L., David E Hibbs, Sorrell, T., Jessica J Talbot, Subedi, Shradha, Biswas, Chayanika, Francisco J Lopez-Ruiz, Vanessa R Barrs, Biswas, C., Lincoln Harper, Hibbs, David E, Cuddy, William S, Chayanika Biswas, Tania C Sorrell, Subedi, S., Dee Carter, Catriona L Halliday, Carter, Dee, Lai, F., Halliday, C., Lai, Felcia, Barrs, V., Sorrell, Tania C, Chen, S., Shradha Subedi, Hibbs, D., Cuddy, W., Felcia Lai, Cooley, Louise, Carter, D., Halliday, Catriona L, Sharon C -A Chen, Talbot, Jessica J   +44 more
core   +1 more source

Accessing diverse azole carboxylic acid building blocks via mild C-H carboxylation: Parallel, one-pot amide couplings and ML-guided substrate scope design [PDF]

, 2022
This manuscript describes a mild, functional group tolerant, and metal-free C-H carboxylation that enables direct access to azole-2-carboxylic acids, followed by amide couplings in one pot.
Michael, Shevlin, Mark, Weisel, Marion H., Emmert, Cyndi Q., He, Stephanie, Felten   +4 more
core   +1 more source