Results 31 to 40 of about 30,366 (254)

Transcriptome profiling of the response of Mycosphaerella graminicola isolates to an azole fungicide using cDNA microarrays [PDF]

, 2007
Resistance to azole antifungals is a major problem in the control of diseases caused by fungal pathogens of both humans and plants. Potential for the development of azole resistance in the wheat leaf blotch pathogen Mycosphaerella graminicola, the causal
TIM P. BEAN, Bean, T. P., BART A. FRAAIJE, JOHN A. LUCAS, Fraaije, B. A., HANS J. COOLS, JOHN ANTONIW, Antoniw, J. F., Lucas, J. A., Cools, H. J.   +9 more
core   +1 more source

Recognition of Azole-Resistant Aspergillosis by Physicians Specializing in Infectious Diseases, United States

Emerging Infectious Diseases, 2018
Infections caused by pan–azole-resistant Aspergillus fumigatus strains have emerged in Europe and recently in the United States. Physicians specializing in infectious diseases reported observing pan–azole-resistant infections and low rates of ...
Tiffany A. Walker, Shawn R. Lockhart, Susan E. Beekmann, Philip M. Polgreen, Scott Santibanez, Rajal K. Mody, Karlyn D. Beer, Tom M. Chiller, Brendan R. Jackson   +8 more
doaj   +1 more source

An Erg11 lanosterol 14-α-demethylase-Arv1 complex is required for Candida albicans virulence.

PLoS ONE, 2020
Azole resistant fungal infections remain a health problem for the immune compromised. Current therapies are limited due to rises in new resistance mechanisms.
Michelle L Villasmil, Antonio Daniel Barbosa, Jessie Lee Cunningham, Symeon Siniossoglou, Joseph T Nickels   +4 more
doaj   +1 more source

A novel substitution 1381V in the sterol 14alpha-demethylase (CYP51) of Mycosphaerella graminicola is differentially selected by azole fungicides [PDF]

, 2007
The recent reduction in the efficacy of azole fungicides in controlling Septoria leaf blotch of wheat, caused by Mycosphaerella graminicola, has prompted concerns over possible development of resistance, particularly in light of the recent emergence of ...
H. J. COOLS, S‐H. KIM, W. S. CLARK, Fraaije, B. A., Motteram, J., B. A. FRAAIJE, Lucas, J. A., J. MOTTERAM, J. A. LUCAS, Kim, S-H., Clark, W. S., Cools, H. J.   +11 more
core   +1 more source

Harnessing the Reactivity of Sulfinate Salts With Cystine: An Umpolung Approach to Residue‐Specific Peptide Modification

Angewandte Chemie, EarlyView.
While cysteine is widely employed as a nucleophilic handle for peptide modification, the electrophilicity of the oxidized form, cystine, is rarely exploited. This study describes a mild, photochemical coupling of sulfinate salts with peptide disulfides.
Joshua M. Hammond, Esteban Suárez‐Picado, Lena von Sydow, Hanna Bruss, Laurent Knerr, Magnus Johansson, Anaïs Noisier, Lara R. Malins   +7 more
wiley   +2 more sources

Augmenting Azoles with Drug Synergy to Expand the Antifungal Toolbox

Pharmaceuticals, 2022
Fungal infections impact the lives of at least 12 million people every year, killing over 1.5 million. Wide-spread use of fungicides and prophylactic antifungal therapy have driven resistance in many serious fungal pathogens, and there is an urgent need ...
Aidan Kane, Dee A. Carter
doaj   +1 more source

Species Distribution and in Vitro Antifungal Susceptibility of Oral Yeast Isolates from Tanzanian HIV-Infected Patients With Primary and Recurrent Oropharyngeal Candidiasis. [PDF]

, 2008
\ud In Tanzania, little is known on the species distribution and antifungal susceptibility profiles of yeast isolates from HIV-infected patients with primary and recurrent oropharyngeal candidiasis.
Rijs Antonius JMM, Mugusi Ferdinand, Simon Elison NM, van der Ven, A.J., Rijs, A.J.M.M, Verweij, P.E., Verweij, P.E, Simon, Elison N M, Matee, Mecky I N, Palenstein Helderman, W.H. van, Moshi, M.J, Van Palenstein Helderman, W.H, Moshi, Mainen J, Rijs, Antonius J M M, Hamza, O.J.M., Wim Helderman, Frans HM Mikx, Simon, E.N.M., Verweij, Paul E, Ferdinand Mugusi, Mugusi, Ferdinand, Hamza, Omar J M, van der Ven André JAM, Antonius JMM Rijs, Mikx, F.H.M., Rijs, A.J.M.M., Elison NM Simon, Ven, A.J.A.M. van der, Mikx Frans HM, Matee Mecky IN, Matee, M.I.N, Simon, E.N., Verweij Paul E, Paul E Verweij, Helderman, W.H.P., Moshi, M.J., Moshi Mainen J, Simon, E.N.M, Helderman, Wim H van Palenstein, André JAM van der Ven, Mecky IN Matee, Mikx, Frans H M, Omar JM Hamza, Mugusi, F., van der Ven, André J A M, Mainen J Moshi, Matee, M.I.N., Mikx, F.H.M, Van der Ven, A.J.A.M, Hamza, O.J.M, Hamza Omar JM, Helderman Wim   +51 more
core   +1 more source

Borylcyclopropanes: Synthetic Strategies and Applications

Angewandte Chemie, EarlyView.
Borylcyclopropanes (cyclopropanes bearing a boron substituent) sit at the intersection of two privileged frameworks in synthesis. This review provides the first exhaustive survey of their chemistry, spanning metal–carbene, nucleophilic cyclization, radical, hydroboration, and C─H activation routes, and documenting applications in medicinal chemistry ...
Aiza A. Butt, Joseph M. Ready
wiley   +2 more sources

Carbonic Anhydrase II Activators in Osteopetrosis Treatment: A Review

Current Issues in Molecular Biology, 2023
Osteopetrosis is a rare hereditary illness generated by failure in osteoclasts resulting in elevated bone densities. Patients with osteopetrosis possess several complications, like dental caries, earlier teeth loss, delayed eruption, malformed crowns and
Zikra Alkhayal, Zakia Shinwari, Ameera Gaafar, Ayodele Alaiya   +3 more
doaj   +1 more source

Pharmacology of new azole antifungal drugs [PDF]

, 2020
About new azole drugs and their relevance in the futurehbkáltalános orvosangolegységes ...
Krümmel, Fabian
core