Results 51 to 60 of about 33,379 (274)

The one health problem of azole resistance in Aspergillus fumigatus:current insights and future research agenda [PDF]

, 2020
Azole resistance is a concern for the management of diseases caused by Aspergillus fumigatus in humans. Azole fungicide use in the environment has been identified as a possible cause for development of resistance, which increases the complexity and ...
Hoogendijk, Andre, Dyer, P. S., Melchersa, Willem J. G., Bowyer, P., Rietveld, A. G., Melchers, Willem J.G., Kiers, Eric, Kiers, E., Fisher, Matthew C., Denningi, David W., Gisi, Ulrich, Zwaanv, Bas J., Brinkmann, A. J. F., Fraaije, B. A., Bowyer, Paul, Verweij, Paul E., Lucas, J., Rhodes, J., Lagrou, K., Zwaan, B. J., Fisher, M. C., Brinkmann, Arjen J. F., Brinkmann, Arjen J.F., Hermann, D., Rhodes, Johanna; id_orcid, Dyer, Paul S., Geenen, Petra L., Schoustra, Sijmen E., Denning, D. W., Brinkmannh, Arjen J. F., Lagrou, Katrien, Stenzelp, Klaus, Hermanno, Dietrich, Gisin, Ulrich, Denning, David W., Rietveld, Anton G., Melchers, W. J. G., Zwaan, Bas J., Gisi, U., Arendrup, Maiken Cavling, Bowyerg, Paul, Geenen, P. L., Hoogendijkq, Andre, Rhodes, Johanna, Arendrup, M. C., Fraaijec, Bart A., Schoustra, S. E., Geenenm, Petra L., Denning, D W; id_orcid, Lucasc, John A., Arendrupd, Maiken C., Stenzel, K., Verweij, P. E., Dyerk, Paul S., Schoustrav, Sijmen E., Stenzel, Klaus, Fraaije, Bart A., Hoogendijk, A., Fisherl, Matthew C., Rhodesl, Johanna, Lagrous, Katrien, Lucas, John A., Arendrup, Maiken C., Verweija, Paul E., Hermann, Dietrich, Rietveldu, Anton G.   +65 more
core   +1 more source

Site Selective Nucleophilic Aromatic Substitutions of Azole-Ligated Diaryliodonium Salts [PDF]

, 2022
Diaryliodonium salts are established electrophilic arylation reagents both in transition metal-catalyzed and transition metal-free reaction methods. Herein we present the application of azole-stabilized diaryliodonium salts with additional thiophen-2-yl ...
Nikita S., Antonkin, Thomas J., Kuczmera, Yulia A., Vlasenko, Boris J., Nachtsheim, Pavel S., Postnikov   +4 more
core   +2 more sources

Repurposing FDA‐Approved Drugs to Inhibit Fungal PPTases for Broad‐Spectrum Synergy

Advanced Science, EarlyView.
Fungal secondary metabolites serve as crucial virulence effectors; however, the potential of their biosynthetic pathways as antifungal targets remains inadequately comprehended. Repurposed FDA‐approved drugs inhibit fungal PPTase (essential for secondary metabolism) in vivo.
Zili Song, Can Zhao, Qiaoling Wang, Hongjiao Zhang, Xiao Liu, Linqi Wang, Michael Bromley, Wen‐Bing Yin   +7 more
wiley   +1 more source

Drug-Resistant Fungi: An Emerging Challenge Threatening Our Limited Antifungal Armamentarium

Antibiotics, 2020
The high clinical mortality and economic burden posed by invasive fungal infections (IFIs), along with significant agricultural crop loss caused by various fungal species, has resulted in the widespread use of antifungal agents.
Amir Arastehfar, Toni Gabaldón, Rocio Garcia-Rubio, Jeffrey D. Jenks, Martin Hoenigl, Helmut J. F. Salzer, Macit Ilkit, Cornelia Lass-Flörl, David S. Perlin   +8 more
doaj   +1 more source

Hospital Environment as a Source of Azole-Resistant Aspergillus fumigatus Strains with TR34/L98H and G448S Cyp51A Mutations

Journal of Fungi, 2021
Azole-resistant Aspergillus fumigatus is an emerging worldwide problem with increasing reports of therapy failure cases produced by resistant isolates. A case of azole-resistant A.
Irene Gonzalez-Jimenez, Jose Lucio, Maria Dolores Menéndez-Fraga, Emilia Mellado, Teresa Peláez   +4 more
doaj   +1 more source

Enhanced Endophytic Colonization of Flavobacterium Promotes Plant Resistance to Fusarium Wilt

Advanced Science, EarlyView.
A natural microbial consortium employing a cross‐feeding strategy forms a stratified biofilm that promotes endophytic colonization of auxotrophic Flavobacterium. This enhanced colonization activates plant systemic resistance, effectively suppressing Fusarium wilt.
Xianfeng Ye, Changsheng Xu, Shuai Yao, Jiming Shen, Zeyuan Li, Yu Zhang, Fan Wu, Xinjie Li, Yanling Ji, Lei Zhang, Yan Huang, Zhoukun Li, Huayu Qin, Zhongli Cui   +13 more
wiley   +1 more source

The biochemical-mode of action of some newer azole fungicides

, 1993
The effects of the newer azole fungicides BAS 480F, flusilazole, and tebuconazole on growth and sterol composition of the plant pathogenic fungi Botrytis cinerea, Pyrenophora teres, Pyricularia oryzae, Rhynchosporium secalis, Ustilago maydis and Erysiphe
R. Thomas Loeffler, Iris M.‐Y. Kwok, Kwok, I. M. Y., Loeffler, R. T.   +3 more
core   +1 more source

The MoSR‐MoDde1 Regulatory Axis: A Novel Determinant of DMI Sensitivity and a Target for Sustainable Rice Blast Control

Advanced Science, EarlyView.
The transcription factor MoSR governs DMI fungicide sensitivity in Magnaporthe oryzae through dual regulation of ergosterol biosynthesis and the detoxification enzyme MoDde1. Targeting MoDde1 via a small‐molecule inhibitor or host‐induced gene silencing enhances DMI efficacy against rice blast, offering a sustainable disease management strategy ...
Fan‐Zhu Meng, Wen‐Kai Wei, Meng‐Yao Wu, Min‐Zheng Cai, Yu‐Fu Wang, Li Zhao, Shuai Meng, Liang‐Fen Yin, Guido Schnabel, Wei‐Xiao Yin, Chao‐Xi Luo   +10 more
wiley   +1 more source

High-Level Pan-Azole-Resistant Aspergillosis [PDF]

, 2015
Contains fulltext : 152983.pdf (Publisher’s version ) (Open Access)High-level pan-azole-resistant Aspergillus fumigatus was recovered from four patients with chronic lung disease.
Snelders, Eveline, Lee, H.A.L. van der, Snelders, E., Melchers, W.J.G., Van Der Lee, Henrich A.L., Verweij, Paul E., Ingen, J. van, Rijs, Antonius J.M.M., Melchers, Willem J.G., Rijs, A.J.M.M., Verweij, P.E., Van Ingen, Jakko   +11 more
core   +2 more sources

The Hsp90 co-chaperones Sti1, Aha1, and P23 regulate adaptive responses to antifungal azoles

Frontiers in Microbiology, 2016
Heat Shock Protein 90 (Hsp90) is essential for tumor progression in humans and drug resistance in fungi. However, the roles of its many co-chaperones in antifungal resistance are unknown. In this study, by susceptibility test of Neurospora crassa mutants
Xiaokui Gu, Wei Xue, Yajing Yin, Hongwei Liu, Shaojie Li, Xianyun Sun   +5 more
doaj   +1 more source