Results 71 to 80 of about 33,379 (274)

An Erg11 lanosterol 14-α-demethylase-Arv1 complex is required for Candida albicans virulence.

PLoS ONE, 2020
Azole resistant fungal infections remain a health problem for the immune compromised. Current therapies are limited due to rises in new resistance mechanisms.
Michelle L Villasmil, Antonio Daniel Barbosa, Jessie Lee Cunningham, Symeon Siniossoglou, Joseph T Nickels   +4 more
doaj   +1 more source

Novel approach for azole fungicides extraction from aqueous environments using terpenes and eutectic solvents

, 2023
The presence of azole fungicides in aquatic environments is a significant issue due to their toxicity and persistence related to a low removal of these compounds by conventional processes in wastewater treatment plants.
Juan García, Marcos Larriba, Enrique García-Fernández de la Puente, Rodríguez Llorente, Diego, García Fernández de la Puente, Enrique, Larriba Martínez, Marcos, Diego Rodríguez-Llorente, García Rodríguez, Juan   +7 more
core   +1 more source

Assessment of azole resistance in healthcare facilities

, 2021
Azole resistance among fungal species has been increasing worldwide in recent years, representing a public health concern in the management of fungal infections.
Costa, Natália, Caetano, Liliana Aranha, Cátia Oliveira, Natália Costa, Liliana A. Caetano, Oliveira, Cátia   +5 more
core   +1 more source

Azole Resistance in Aspergillus fumigatus: A Consequence of Antifungal Use in Agriculture?

Frontiers in Microbiology, 2017
Agricultural industry uses pesticides to optimize food production for the growing human population. A major issue for crops is fungal phytopathogens, which are treated mainly with azole fungicides.
Sarah Berger, Yassine El Chazli, Ambrin F. Babu, Alix T. Coste   +3 more
doaj   +1 more source

Molecular Modelling of the Emergence of Azole Resistance in Mycosphaerella graminicola [PDF]

, 2011
A structural rationale for recent emergence of azole (imidazole and triazole) resistance associated with CYP51 mutations in the wheat pathogen Mycosphaerella graminicola is presented, attained by homology modelling of the wild type protein and 13 variant
Roberto C. Togawa, Bart A. Fraaije, Jonathan G L Mullins, Mullins Jonathan G. L., Togawa Roberto C., Josie Parker, Hans J Cools, Fraaije, B. A., Cools Hans J., Steven Kelly, Fraaije Bart A., Kelly Steven L., Mullins, J. G. L., Steven L. Kelly, Parker, J. E., Lucas, J. A., Josie E Parker, Roberto C Togawa, Hans J. Cools, Kelly, D. E., Jonathan G. L. Mullins, John A Lucas, Parker Josie E., Diane E Kelly, Kelly Diane E., Diane E. Kelly, Jonathan Mullins, Lucas John A., Josie E. Parker, Steven L Kelly, Kelly, S. L., Togawa, R. C., John A. Lucas, Diane Kelly, Bart A Fraaije, Cools, H. J.   +35 more
core   +1 more source

Use of Clotrimazole in Finfish Aquaculture: Mechanistic Insights, Limitations, and Future Directions for Antifungal Therapy

Animal Research and One Health, EarlyView.
This review critically evaluates clotrimazole as a potential antifungal for finfish aquaculture, highlighting strong mechanistic and in vitro efficacy against aquatic mycoses alongside major gaps in in vivo evidence, toxicokinetics, residue safety, and environmental risk, outlining priorities for responsible therapeutic development and regulatory ...
Arya Sen, Debashri Mondal, Thangapalam Jawahar Abraham   +2 more
wiley   +1 more source

Role of isavuconazole in the treatment of invasive fungal infections

Therapeutics and Clinical Risk Management, 2016
Dustin T Wilson,1,2 V Paul Dimondi,1,3 Steven W Johnson,1,4 Travis M Jones,1 Richard H Drew1,5 1Department of Pharmacy Practice, Campbell University College of Pharmacy & Health Sciences, Buies Creek, NC, USA; 2Department of Pharmacy, Duke ...
Wilson DT, Dimondi VP, Johnson SW, Jones TM, Drew RH   +4 more
doaj  

Are azole fungicides losing ground against Septoria wheat disease? Resistance mechanisms in Mycosphaerella graminicola

, 2008
There has been a recent rapid decline in the efficacy of some, but not all, azole fungicides in controlling the Septoria leaf blotch pathogen of wheat, Mycosphaerella graminicola. Hans J. Cools and Bart A.
Fraaije, B. A., Hans J Cools, Cools, H. J., Bart A Fraaije   +3 more
core   +1 more source

Azole sensitivity in Leptosphaeria pathogens of oilseed rape: the role of lanosterol 14α-demethylase [PDF]

, 2017
Lanosterol 14-α demethylase is a key enzyme intermediating the biosynthesis of ergosterol in fungi, and the target of azole fungicides. Studies have suggested that Leptosphaeria maculans and L. biglobosa, the causal agents of phoma stem canker on oilseed
Hawkins, N. J., Fitt, Bruce, Thomas R. Sewell, Bart Fraaije, Sewell, Thomas R, Fraaije, B. A., Steven Kelly, Nichola J. Hawkins, Steven L. Kelly, Kelly, Steven L, Sewell, Thomas, Henrik U. Stotz, YongJu Huang, Hawkins, Nichola J, Kelly, D. E., Huang, YongJu, E Kelly, Diane, J Hawkins, Nichola, Stotz, Henrik, Fraaije, Bart, Diane E. Kelly, L Kelly, Steven, Fitt, B. D. L., Stotz, Henrik U, Bruce D. L. Fitt, Kelly, Diane E, Sewell, T. R., Fitt, Bruce DL, Stotz, H. U., Huang, Y. J., Kelly, S. L., Diane Kelly   +31 more
core   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source