Results 81 to 90 of about 33,379 (274)

A narrow bandgap Schottky heterojunction Fe2N/CeO2 microneedle triggering sonodynamic reactive oxygen species storm for drug‐resistance‐free skin fungal infection

BMEMat, EarlyView.
Inorganic sonosensitizers suffer from inefficient electron‐hole separation, rapid recombination, and wide bandgaps in anti‐fungal applications. We propose MN@Fe2N/CeO2 to directly eliminate fungi without drug resistance. Combining semiconductor CeO2's advantages with Fe2N's high work function and activity enables efficient Schottky heterojunctions ...
Li Wang, Jiayi Yang, Ning Tang, Youbin Zheng, Yichao Hou, Chutong Liu, Lihao Guo, Yingying Liao, Gandong Zhou, Weiwei Wu, Xin Du, Shuxiang Xu, Jie Yin, Miaomiao Yuan   +13 more
wiley   +1 more source

An Overview of Pyrazole-Tetrazole-Based Hybrid Compounds: Synthesis Methods, Biological Activities and Energetic Properties

Organics
Pyrazole and tetrazole are among the most important heterocyclic members of the azole family. Over the past decade, these N-heterocycles and their derivatives have demonstrated specific properties that give them potent applications in several fields such
Mounir Cherfi, Tarik Harit, Malika Amanchar, Ahlam Oulous, Fouad Malek   +4 more
doaj   +1 more source

Impact of Recently Emerged Sterol 14 alpha-Demethylase (CYP51) Variants of Mycosphaerella graminicola on Azole Fungicide Sensitivity

, 2011
The progressive decline in the effectiveness of some azole fungicides in controllingMycosphaerella graminicola, causal agent of the damaging Septoria leaf blotch disease of wheat, has been correlated with the selection and spread in the ...
Kelly, D. E., Jonathan G. L. Mullins, Bart A. Fraaije, Diane E. Kelly, Jonathan Mullins, Josie Parker, Josie E. Parker, Fraaije, B. A., Steven Kelly, Mullins, J. G. L., Kelly, S. L., Steven L. Kelly, John A. Lucas, Parker, J. E., Diane Kelly, Lucas, J. A., Hans J. Cools, Cools, H. J.   +17 more
core   +1 more source

Alterations in predicted regulatory and coding regions of the sterol 14α-demethylase gene (CYP51) confer decreased azole sensitivity in the oilseed rape pathogen Pyrenopeziza brassicae [PDF]

, 2014
The incidence and severity of light leaf spot epidemics caused by the ascomycete fungus Pyrenopeziza brassicae on UK oilseed rape crops is increasing.
Mehl, Andreas, Shaw, M. W., Shaw, Michael W., Cools, Hans J., West, Jonathan S., Kelly, Steven L., Fraaije, B. A., Mehl, A., Steven Kelly, Fraaije, Bart A., Carter, Helen E., Kelly, S. L., Carter, H. E., West, J. S., Cools, H. J.   +14 more
core   +1 more source

Phosphonomethyl (Thio)Phosphonamidite Reagents for the Construction of Phosphonylmethyl Phosphono(Di)Thioate Mono‐ and Diesters

Chemistry – A European Journal, EarlyView.
A set of new phosphonomethyl (thio)phosphonamidite reagents is introduced to generate unprecedented pyrophosphate mimetics. The versatile P(III)‐P(V) reagents allow for the construction of various pyrophosphate isosteres, and the applicability of the chemistry is illustrated in the assembly of a diverse set of stabilized CDP‐glycerol and CDP‐ribitol ...
Pascal Balić, Roy Steneker, Gijsbert A. van der Marel, Jeroen D. C. Codée, Dmitri V. Filippov   +4 more
wiley   +1 more source

Aneuploidy is associated with azole resistance in Aspergillus fumigatus

, 2023
Azole resistance in Aspergillus fumigatus is on the rise. Non-target mediated mechanisms are a common cause of azole resistance in chronic pulmonary aspergillosis (CPA). Here we investigate resistance mechanisms using whole genome sequencing.
Richardson, Malcolm, Gago, Sara; id_orcid, Bowyer, Paul, Khateb, Aiah, Bromley, Michael; id_orcid   +4 more
core   +1 more source

Molecular Modification Strategies for CO2 Electroreduction to C2+ Products: Classifications, Mechanisms, Advances, and Perspectives

EcoEnergy, EarlyView.
This review comprehensively outlines molecular modification strategies for steering CO2 electroreduction toward C2+ products, including the classification of diverse molecular structures, elucidation of their roles in microenvironment regulation, dissection of C–C coupling pathway engineering, and forward‐looking perspectives on machine learning and ...
Lingling Peng, Hanwen Liu, Tianyou Peng
wiley   +1 more source

Evolution and spread of azole-insensitive Zymoseptoria tritici field isolates in the UK [PDF]

, 2014
Azole fungicides have been used for more than three decades in the UK to control Septoria leaf blotch caused by the fungus Zymoseptoria tritici. Research has shown that the efficacy of some azoles (e.g. tebuconazole and triadimenol) can be compromised by
Fraaije, B. A., Hawkins, N. J., Atkins, S., Diez De La Fuente, P., Luo, J.   +4 more
core  

Selective N‐Functionalization of Pyrazoles

European Journal of Organic Chemistry, EarlyView.
This review traces the evolution of regioselective N‐functionalization strategies for pyrazoles, a key class of nitrogen heterocycles widely used in medicinal chemistry. Due to rapid tautomerism, N‐functionalization often lacks selectivity, leading to poor and unpredictable regioisomeric outcomes.
Lucas Popek, Matthias Schrader, Christopher J. Teskey   +2 more
wiley   +1 more source

A Novel Environmental Azole Resistance Mutation in Aspergillus fumigatus and a Possible Role of Sexual Reproduction in Its Emergence

mBio, 2017
This study investigated the dynamics of Aspergillus fumigatus azole-resistant phenotypes in two compost heaps with contrasting azole exposures: azole free and azole exposed.
Jianhua Zhang, Eveline Snelders, Bas J. Zwaan, Sijmen E. Schoustra, Jacques F. Meis, Karin van Dijk, Ferry Hagen, Martha T. van der Beek, Greetje A. Kampinga, Jan Zoll, Willem J. G. Melchers, Paul E. Verweij, Alfons J. M. Debets   +12 more
doaj   +1 more source