Results 81 to 90 of about 30,366 (254)

Use of Clotrimazole in Finfish Aquaculture: Mechanistic Insights, Limitations, and Future Directions for Antifungal Therapy

Animal Research and One Health, EarlyView.
This review critically evaluates clotrimazole as a potential antifungal for finfish aquaculture, highlighting strong mechanistic and in vitro efficacy against aquatic mycoses alongside major gaps in in vivo evidence, toxicokinetics, residue safety, and environmental risk, outlining priorities for responsible therapeutic development and regulatory ...
Arya Sen, Debashri Mondal, Thangapalam Jawahar Abraham   +2 more
wiley   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Molecular Modelling of the Emergence of Azole Resistance in Mycosphaerella graminicola [PDF]

, 2011
A structural rationale for recent emergence of azole (imidazole and triazole) resistance associated with CYP51 mutations in the wheat pathogen Mycosphaerella graminicola is presented, attained by homology modelling of the wild type protein and 13 variant
Roberto C. Togawa, Bart A. Fraaije, Jonathan G L Mullins, Mullins Jonathan G. L., Togawa Roberto C., Josie Parker, Hans J Cools, Fraaije, B. A., Cools Hans J., Steven Kelly, Fraaije Bart A., Kelly Steven L., Mullins, J. G. L., Steven L. Kelly, Parker, J. E., Lucas, J. A., Josie E Parker, Roberto C Togawa, Hans J. Cools, Kelly, D. E., Jonathan G. L. Mullins, John A Lucas, Parker Josie E., Diane E Kelly, Kelly Diane E., Diane E. Kelly, Jonathan Mullins, Lucas John A., Josie E. Parker, Steven L Kelly, Kelly, S. L., Togawa, R. C., John A. Lucas, Diane Kelly, Bart A Fraaije, Cools, H. J.   +35 more
core   +1 more source

A narrow bandgap Schottky heterojunction Fe2N/CeO2 microneedle triggering sonodynamic reactive oxygen species storm for drug‐resistance‐free skin fungal infection

BMEMat, EarlyView.
Inorganic sonosensitizers suffer from inefficient electron‐hole separation, rapid recombination, and wide bandgaps in anti‐fungal applications. We propose MN@Fe2N/CeO2 to directly eliminate fungi without drug resistance. Combining semiconductor CeO2's advantages with Fe2N's high work function and activity enables efficient Schottky heterojunctions ...
Li Wang, Jiayi Yang, Ning Tang, Youbin Zheng, Yichao Hou, Chutong Liu, Lihao Guo, Yingying Liao, Gandong Zhou, Weiwei Wu, Xin Du, Shuxiang Xu, Jie Yin, Miaomiao Yuan   +13 more
wiley   +1 more source

Azole sensitivity in Leptosphaeria pathogens of oilseed rape: the role of lanosterol 14α-demethylase [PDF]

, 2017
Lanosterol 14-α demethylase is a key enzyme intermediating the biosynthesis of ergosterol in fungi, and the target of azole fungicides. Studies have suggested that Leptosphaeria maculans and L. biglobosa, the causal agents of phoma stem canker on oilseed
Hawkins, N. J., Fitt, Bruce, Thomas R. Sewell, Bart Fraaije, Sewell, Thomas R, Fraaije, B. A., Steven Kelly, Nichola J. Hawkins, Steven L. Kelly, Kelly, Steven L, Sewell, Thomas, Henrik U. Stotz, YongJu Huang, Hawkins, Nichola J, Kelly, D. E., Huang, YongJu, E Kelly, Diane, J Hawkins, Nichola, Stotz, Henrik, Fraaije, Bart, Diane E. Kelly, L Kelly, Steven, Fitt, B. D. L., Stotz, Henrik U, Bruce D. L. Fitt, Kelly, Diane E, Sewell, T. R., Fitt, Bruce DL, Stotz, H. U., Huang, Y. J., Kelly, S. L., Diane Kelly   +31 more
core   +1 more source

The Lipid Composition of Azole-sensitive and Azole-resistant Strains of Candida albicans [PDF]

Microbiology, 1986
The lipid compositions of two azole-sensitive (A and B2630) and two azole-resistant (AD and KB) strains of the opportunistic fungal pathogen Candida albicans were studied by using several lipid extraction procedures: no differences were observed between the lipid content or total phospholipid/neutral lipid ratios of the four strains.
C A, Hitchcock, K J, Barrett-Bee, N J, Russell   +2 more
openaire   +2 more sources

Fungal Antimicrobial Resistance: Mechanisms, Drivers, and Global Clinical Burden

ChemFoodChem, EarlyView.
ABSTRACT Fungal antimicrobial resistance (AMR) is a growing concern for world health caused by an increase in multidrug‐resistant infections, an increase in environmental reservoirs, and the ineffectiveness of current antifungal treatments. Fungal infections continue to be largely excluded from AMR initiatives while causing over 1.6 million deaths ...
Bikash Baral
wiley   +1 more source

PDR16-mediated azole resistance in Candida albicans [PDF]

, 2006
Many Candida albicans azole-resistant (AR) clinical isolates overexpress the CDR1 and CDR2 genes encoding homologous multidrug transporters of the ATP-binding cassette family.
Raymond, Martine, Saint-Germain, Goy, De Deken, Xavier, Saidane, Saloua, Weber, Sandra   +4 more
core   +1 more source

Role of isavuconazole in the treatment of invasive fungal infections

Therapeutics and Clinical Risk Management, 2016
Dustin T Wilson,1,2 V Paul Dimondi,1,3 Steven W Johnson,1,4 Travis M Jones,1 Richard H Drew1,5 1Department of Pharmacy Practice, Campbell University College of Pharmacy & Health Sciences, Buies Creek, NC, USA; 2Department of Pharmacy, Duke ...
Wilson DT, Dimondi VP, Johnson SW, Jones TM, Drew RH   +4 more
doaj  

The Stabilization of High‐Nitrogen Systems: 10 Catenated Nitrogen Chain

Chemistry – A European Journal, EarlyView.
Improving the understanding of high‐nitrogen materials. ABSTRACT High‐nitrogen materials have attracted intense interest in recent decades due to their unique chemical, physical, and biological properties. Stabilizing high‐nitrogen materials is often challenging as they become more unstable with increasing nitrogen catenation and nitrogen mass ...
Nicholas F. Scherschel, Thomas R. Talbot IV, Matthias Zeller, Davin G. Piercey   +3 more
wiley   +1 more source