Results 91 to 100 of about 33,379 (274)
European Journal of Organic Chemistry, EarlyView.A practical strategy for synthesizing β‐ and γ‐carbolinones from indole‐based Ugi 4‐CR adducts through an intramolecular radical cyclization using Fe(III)–H species is presented. This approach enables the efficient synthesis of spiro‐carbolinones under mild reaction conditions and demonstrates the effectiveness of secondary radicals in both cyclization
María F. Olvera‐Granados +1 more
wiley +1 more source
Spectrum of activity and mechanisms of azole–bisphosphonate synergy in pathogenic Candida
Microbiology SpectrumCandidiasis places a significant burden on human health and can range from common superficial vulvovaginal and oral infections to invasive diseases with high mortality.
Aidan Kane +5 more
doaj +1 more source
, 1998 We investigated the effects of combining tacrolimus and azole antifungal agents in azole-resistant strains of Candida albicans by comparing the accumulation of [3H]itraconazole.
Marichal, P. +5 more
core +1 more source
Aspartic Protease Inhibition Induces Proteomic Remodeling in Paracoccidioides brasiliensis
PROTEOMICS, EarlyView.ABSTRACT Paracoccidioidomycosis (PCM) is a major systemic mycosis in Latin America caused by Paracoccidioides brasiliensis, yet the contribution of aspartic proteases to fungal physiology and pathogenicity remains poorly understood. Here, we employed data‐independent acquisition (DIA)‐based quantitative proteomics to investigate the impact of pepstatin
Sarah Fernandes Lima +6 more
wiley +1 more source
Use of loop-mediated isothermal amplification assays to detect azole-insensitive CYP51- overexpressing strains of Zymoseptoria tritici [PDF]
, 2014 Septoria leaf blotch is currently controlled by programmed applications of multisite inhibitors (e.g. chlorothalonil), azoles (e.g. epoxiconazole and prothioconazole) and a new generation of Succinate Dehydrogenase Inhibitors (e.g.
Fraaije, B. A.
core
Azole resistance in Aspergillus fumigatus
, 2008 Invasive aspergillosis remains an important complication of immunosuppressive treatment regimens in humans. Triazoles are increasingly used in the prevention and management of invasive aspergillosis.
Snelders, Eveline +2 more
core +1 more source
Endosomal Trafficking Defects Can Induce Calcium-Dependent Azole Tolerance in Candida albicans.
, 2019 Artículo digitalThe azole antifungals arrest fungal growth through inhibition of ergosterol biosynthesis. We recently reported that a Candida albicans vps21 / mutant, deficient in membrane trafficking through the late endosome/prevacuolar compartment ...
Peters, Tracy L. +3 more
core +1 more source
Prediction of Prion Proteins in E. coli Based on Bimodal Sequence Characteristics
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT Prions are infectious proteins that bear misfolded conformations capable of converting folded states into misfolded aggregates under physiologically relevant conditions. In mammals, prions cause deadly maladies including Creutzfeldt‐Jakob and chronic wasting disease. To date, several prion proteins have been identified in eukaryotes, primarily
Katherine Shreeve +5 more
wiley +1 more source
Frontiers in Microbiology, 2013 Antifungal azoles inhibit ergosterol biosynthesis by interfering with lanosterol 14α-demethylase. In this study, 7 upregulated and 4 downregulated ergosterol biosynthesis genes in response to ketoconazole treatment were identified in Neurospora crassa ...
Xianyun eSun +7 more
doaj +1 more source
Pest Management Science, EarlyView.For three collections of Irish Pyrenopeziza brassicae populations fungicide sensitivity status to methyl benzimidazole carbamate (MBC), quinone outside inhibitor (QoI) and succinate dehydrogenase inhibitor (SDHI) fungicides was determined using sensitivity screening in vitro. Molecular mechanisms of insensitivity have been identified for MBC and QoI in
Diana E Bucur +3 more
wiley +1 more source