Results 1 to 10 of about 16,526 (218)
Molecular characterization of Echinocandin resistance and the CHS3-mediated adaptive response in Candida glabrata bloodstream infections in Eastern China [PDF]
BMC MicrobiologyBackground Candidemia caused by Candida glabrata is a serious fungal infection, and rising echinocandin resistance presents a significant clinical challenge.
Peishan Cong +7 more
doaj +2 more sources
Clinical Case Report on the Use of Rezafungin in Pneumocystis jirovecii Pneumonia in a Critically Ill Patient [PDF]
MicroorganismsPneumocystis jirovecii pneumonia (PJP) is a life-threatening opportunistic infection predominantly affecting immunocompromised patients. Trimethoprim–sulfamethoxazole (TMP–SMX) remains the standard therapy but is often limited by severe toxicity ...
Rosario Fernández-Fernández +4 more
doaj +2 more sources
Profound cell wall remodeling in Candida parapsilosis during systemic infection confers simultaneous tolerance to echinocandins and host immunity [PDF]
Microbiology SpectrumAntifungal tolerance can promote the emergence of resistance yet often incurs fitness costs for fungal pathogens. How tolerant populations compensate for these deficits and how they may be therapeutically targeted remain poorly understood.
Farnaz Daneshnia +28 more
doaj +2 more sources
mBio, 2021 Fungal infections cause significant mortality and morbidity worldwide, and the limited existing antifungal reservoir is further weakened by the emergence of strains resistant to echinocandins, a first line of antifungal therapy.
Rocio Garcia-Rubio +5 more
doaj +1 more source
Physiologia, 2023 Echinocandin B is a natural product that possesses potent antifungal property against a wide array of fungi. This antifungal agent is produced by Emericella rugulosa. The biosynthetic genes of echinocandin B are physically organized in two gene clusters (
Vandana Kumari +3 more
doaj +1 more source
Treatment of Primary Pulmonary Aspergillosis: An Assessment of the Evidence. [PDF]
, 2016 Aspergillus spp. are a group of filamentous molds that were first described due to a perceived similarity to an aspergillum, or liturgical device used to sprinkle holy water, when viewed under a microscope.
Stewart, Ethan R, Thompson, George R
core +11 more sources
BMC Microbiology, 2023 Background Candida glabrata is an important cause of invasive candidiasis. Echinocandins are the first-line treatment of invasive candidiasis caused by C. glabrata.
Yi Li +15 more
doaj +1 more source
PLoS Pathogens, 2021 Although considered effective treatment for many yeast fungi, the therapeutic efficacy of the echinocandin class of antifungals for invasive aspergillosis (IA) is limited.
Ana Camila Oliveira Souza +6 more
doaj +1 more source
Global analysis of the evolution and mechanism of echinocandin resistance in Candida glabrata. [PDF]
PLoS Pathogens, 2012 The evolution of drug resistance has a profound impact on human health. Candida glabrata is a leading human fungal pathogen that can rapidly evolve resistance to echinocandins, which target cell wall biosynthesis and are front-line therapeutics for ...
Sheena D Singh-Babak +9 more
doaj +1 more source
Antibiotics, 2023 Delays in the treatment of proven invasive fungal disease have been shown to be harmful. However, empiric treatment for all patients at risk of infection has not demonstrated benefit.
J. Myles Keck +8 more
doaj +1 more source