Results 1 to 10 of about 11,227 (157)

Immunological fitness of echinocandin-resistant Nakaseomyces glabratus (former Candida glabrata): The impact on the management of candidemia [PDF]

Virulence
Nakaseomyces glabratus (formerly Candida glabrata) (N. glabratus) is a commensal yeast that is increasingly associated with invasive candidiasis. The rapid acquisition of echinocandin resistance by N.
Louise Basmaciyan, Nidia Alvarez-Rueda, Delphine Aldebert, Hafsa Sahnouni, Cecile Garnaud, Delphine Patarot, Amandine Ducreux, Fabienne Bon, Pascale Winckler, Patrice Le Pape, Murielle Cornet, Frédéric Dalle   +11 more
doaj   +2 more sources

Decreased echinocandin susceptibility in Candida parapsilosis causing candidemia and emergence of a pan-echinocandin resistant case in China

Emerging Microbes and Infections, 2023
Candida parapsilosis is becoming a predominant non-albicans cause of invasive candidiasis (IC). Echinocandins are the preferred choice for IC treatment and prophylaxis. Resistance to echinocandins in C.
Minya Lu, Zhongju Chen
exaly   +3 more sources

Evolutionary accumulation of FKS 1 mutations from clinical echinocandin-resistant Candida auris

Emerging Microbes and Infections
Introduction: Drug resistance to echinocandins, first-line drugs used to treat Candida auris infection, is rapidly emerging. However, the accumulation of mutations in genes other than FKS1 (before an isolate develops to resistance via FKS1 mutations ...
Hong Shang, Sufei Tian
exaly   +3 more sources

Clinical Case Report on the Use of Rezafungin in Pneumocystis jirovecii Pneumonia in a Critically Ill Patient [PDF]

Microorganisms
Pneumocystis jirovecii pneumonia (PJP) is a life-threatening opportunistic infection predominantly affecting immunocompromised patients. Trimethoprim–sulfamethoxazole (TMP–SMX) remains the standard therapy but is often limited by severe toxicity ...
Rosario Fernández-Fernández, Roberto García-Martínez, Waldo Sánchez-Yebra Fernández, Natalia Chueca-Porcuna, Manuel Colmenero-Ruiz   +4 more
doaj   +2 more sources

Predictors of Candida auris Infection in Previously Colonized Patients: A Retrospective Cohort Study from a Large Tertiary Reference Center [PDF]

Journal of Fungi
Candida auris is a multidrug-resistant fungal pathogen associated with high mortality in healthcare settings. Although colonization is recognized as the harbinger of invasive infection, predicting which patients will develop bloodstream infection (BSI ...
Nadide Ergün, Sevim Selen Karabulut, Melda Türken, Bengü Tatar, Süheyla Serin Senger   +4 more
doaj   +2 more sources

Profound cell wall remodeling in Candida parapsilosis during systemic infection confers simultaneous tolerance to echinocandins and host immunity [PDF]

Microbiology Spectrum
Antifungal tolerance can promote the emergence of resistance yet often incurs fitness costs for fungal pathogens. How tolerant populations compensate for these deficits and how they may be therapeutically targeted remain poorly understood.
Farnaz Daneshnia, Liuyang Cai, Deepika Gunasekaran, Isha Gautam, Austin M. Perry, Pegah Mosharaf Ghahfarokhy, Arefeh Ebadati, Julieta Munoz, Dorian Padilla, Süleyha Hilmioglu-Polat, Shenglin Mei, Daniel J. Floyd, Miquel Àngel Schikora-Tamarit, Diego Fuentes, Maria Artigues-Lleixà, Louise A. Walker, Samuel M. Gonçalves, Mostafa Salehi, Agostinho Carvalho, Jigar V. Desai, David S. Perlin, Carol A. Munro, Alex Hopke, Tuo Wang, Toni Gabaldón, Wenjie Fang, Clarissa J. Nobile, Michael K. Mansour, Amir Arastehfar   +28 more
doaj   +2 more sources

Multifactorial Role of Mitochondria in Echinocandin Tolerance Revealed by Transcriptome Analysis of Drug-Tolerant Cells

mBio, 2021
Fungal infections cause significant mortality and morbidity worldwide, and the limited existing antifungal reservoir is further weakened by the emergence of strains resistant to echinocandins, a first line of antifungal therapy.
Rocio Garcia-Rubio, Cristina Jimenez-Ortigosa, Lucius DeGregorio, Christopher Quinteros, Erika Shor, David S. Perlin   +5 more
doaj   +1 more source

Curcumin Epigenetically Represses Histone Acetylation of Echinocandin B Producing Emericella rugulosa

Physiologia, 2023
Echinocandin B is a natural product that possesses potent antifungal property against a wide array of fungi. This antifungal agent is produced by Emericella rugulosa. The biosynthetic genes of echinocandin B are physically organized in two gene clusters (
Vandana Kumari, Vinay Kumar, Manisha Kaushal, Antresh Kumar   +3 more
doaj   +1 more source

Whole genome analysis of echinocandin non-susceptible Candida Glabrata clinical isolates: a multi-center study in China

BMC Microbiology, 2023
Background Candida glabrata is an important cause of invasive candidiasis. Echinocandins are the first-line treatment of invasive candidiasis caused by C. glabrata.
Yi Li, Xin Hou, Ruoyu Li, Kang Liao, Ling Ma, Xiaoming Wang, Ping Ji, Haishen Kong, Yun Xia, Hui Ding, Wei Kang, Ge Zhang, Jin Li, Meng Xiao, Yingxing Li, Yingchun Xu   +15 more
doaj   +1 more source

Loss of Septation Initiation Network (SIN) kinases blocks tissue invasion and unlocks echinocandin cidal activity against Aspergillus fumigatus.

PLoS Pathogens, 2021
Although considered effective treatment for many yeast fungi, the therapeutic efficacy of the echinocandin class of antifungals for invasive aspergillosis (IA) is limited.
Ana Camila Oliveira Souza, Adela Martin-Vicente, Ashley V Nywening, Wenbo Ge, David J Lowes, Brian M Peters, Jarrod R Fortwendel   +6 more
doaj   +1 more source