Results 31 to 40 of about 16,526 (218)

Recent trends in molecular diagnostics of yeast infections : from PCR to NGS [PDF]

open access: yes, 2019
The incidence of opportunistic yeast infections in humans has been increasing over recent years. These infections are difficult to treat and diagnose, in part due to the large number and broad diversity of species that can underlie the infection.
Arastehfar, A   +26 more
core   +2 more sources

Application of an aculeacin A acylase from Actinoplanes utahensis SW1311 in syntheses of echinocandins

open access: yes浙江大学学报. 农业与生命科学版, 2017
Echinocandins are the first class of antifungals to target fungal cell wall. Two antifungals, including micafungin and anidulafungin, have been widely used in clinic.
FENG Guodong   +6 more
doaj   +1 more source

Evaluation of Fluconazole versus Echinocandins for Treatment of Candidemia Caused by Susceptible Common Candida Species: A Propensity Score Matching Analysis

open access: yesJournal of Fungi, 2023
This study aimed to evaluate the effectiveness of fluconazole and echinocandins in the treatment of candidemia caused by both fluconazole- and echinocandin-susceptible common Candida species. A retrospective study which enrolled adult candidemia patients
Jong Hun Kim, Jin Woong Suh, Min Ja Kim
doaj   +1 more source

Combined antifungal resistance and biofilm tolerance: the global threat of Candida auris [PDF]

open access: yes, 2019
The enigmatic yeast Candida auris has emerged over the last decade and rapidly penetrated our consciousness. The global threat from this multidrug-resistant yeast has generated a call to arms from within the medical mycology community.
Kean, Ryan, Ramage, Gordon
core   +2 more sources

Echinocandin resistance [PDF]

open access: yesCurrent Opinion in Infectious Diseases, 2014
Echinocandin resistance in Candida is a great concern, as the echinocandin drugs are recommended as first-line therapy for patients with invasive candidiasis. Here, we review recent advances in our understanding of the epidemiology, underlying mechanisms, methods for detection and clinical implications.Echinocandin resistance has emerged over the ...
Maiken C, Arendrup, David S, Perlin
openaire   +2 more sources

Breakthrough Candidemia Due to Multidrug-Resistant Candida glabrata during Prophylaxis with a Low Dose of Micafungin [PDF]

open access: yes, 2014
We identified a case of breakthrough candidemia in a 25-year-old patient receiving micafungin prophylaxis (50 mg/day). Five Candida glabrata isolates were obtained from blood cultures and were classified as multidrug-resistant isolates, since all of them
Bizerra, Fernando Cesar   +6 more
core   +2 more sources

Translation inhibition by rocaglates activates a species-specific cell death program in the emerging fungal pathogen Candida auris [PDF]

open access: yes, 2020
Fungal infections are a major contributor to infectious disease-related deaths worldwide. Recently, global emergence of the fungal pathogen Candida auris has caused considerable concern because most C.
Brown, Lauren E.   +6 more
core   +1 more source

Novel Cell Wall Antifungals Reveal a Special Synergistic Activity in pbr1 Mutants Resistant to the Glucan Synthesis Antifungals Papulacandins and Echinocandins

open access: yesFrontiers in Microbiology, 2019
A series of 4-(arylmethylene)-3-isochromanones have been prepared with base-catalyzed Knoevenagel condensation starting from 3-isochromanone and aromatic aldehydes.
Rodrigo Berzaghi   +6 more
doaj   +1 more source

Candida auris, what do paediatricians need to know? [PDF]

open access: yes, 2018
AW is supported by the Wellcome Trust Strategic Award (grant 097377) and the MRC Centre for Medical Mycology (grant MR/N006364/1) at the University of Aberdeen.Peer reviewedPublisher ...
Warris, Adilia
core   +1 more source

Treatment of Invasive Candidiasis: A Narrative Review

open access: yesJournal of Fungi, 2018
Invasive candidiasis occurs frequently in hospitalized patients, and is associated with high mortality rates due to delays in recognition and initiation of appropriate antifungals.
Ronen Ben-Ami
doaj   +1 more source

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