Results 31 to 40 of about 13,385 (164)
Gels, 2023 Caspofungin is a drug that is used for fungal infections that are difficult to treat, including invasive aspergillosis and candidemia, as well as other forms of invasive candidiasis.
Noelia Pérez-González +8 more
doaj +1 more source
Candida parapsilosis isolates carrying mutations outside FKS1 hotspot regions confer high echinocandin tolerance and facilitate the development of echinocandin resistance [PDF]
, 2023 Candida parapsilosis is a significant cause of candidemia worldwide. Echinocandin-resistant (ECR) and echinocandin-tolerant (ECT) C. parapsilosis isolates have been reported in various countries but are rare.
Daneshnia, Farnaz +10 more
core +2 more sources
New Horizons in Antifungal Therapy
Journal of Fungi, 2016 Recent investigations have yielded both profound insights into the mechanisms required by pathogenic fungi for virulence within the human host, as well as novel potential targets for antifungal therapeutics.
Kaila M. Pianalto, J. Andrew Alspaugh
doaj +1 more source
Review of the Novel Echinocandin Antifungal Rezafungin: Animal Studies and Clinical Data
Journal of Fungi, 2020 Rezafungin is a novel echinocandin drug being developed as a first-line option for treatment and prevention of invasive fungal infections. As a result of a structural modification in its parent molecule anidulafungin, rezafungin has acquired unique ...
Yanan Zhao, David S. Perlin
doaj +1 more source
Emerging echinocandin-resistant Candida albicans and glabrata in Switzerland
, 2020 Echinocandins represent the first-line therapy of candidemia. Echinocandin resistance among Candida spp. is mainly due to acquired FKS mutations. In this study, we report the emergence of FKS-mutant Candida albicans/glabrata in Switzerland and provide ...
Lamoth, F +13 more
core +1 more source
Recent Insights into the Paradoxical Effect of Echinocandins
Journal of Fungi, 2017 Echinocandin antifungals represent one of the most important drug classes for the treatment of invasive fungal infections. The mode of action of the echinocandins relies on inhibition of the β-1,3-glucan synthase, an enzyme essentially required for the ...
Johannes Wagener, Veronika Loiko
doaj +1 more source
Drug-Resistant Fungi: An Emerging Challenge Threatening Our Limited Antifungal Armamentarium
Antibiotics, 2020 The high clinical mortality and economic burden posed by invasive fungal infections (IFIs), along with significant agricultural crop loss caused by various fungal species, has resulted in the widespread use of antifungal agents.
Amir Arastehfar +8 more
doaj +1 more source
Australian Veterinary Journal, EarlyView.A 3‐year‐old male Border Collie diagnosed with immune‐mediated dermatopathy, managed with tapering prednisolone and cyclosporine, developed rapidly progressive ocular signs and additional cutaneous lesions. Histopathology, mycological culture, polymerase chain reaction and sequencing confirmed intraocular and cutaneous infection due to Curvularia ...
T Brasil‐Ervedosa +4 more
wiley +1 more source
Internal Medicine Journal, EarlyView.Abstract Chimeric antigen receptor (CAR) T‐cell therapies directed against cluster of differentiation 19 (CD19) are a standard of care for relapsed or refractory B‐cell lymphomas. Infection is the leading cause of non‐relapse mortality, and this risk may persist for years after CAR T‐cell receipt.
Aine Hurley +15 more
wiley +1 more source
Caspofungin Induced Cell Wall Changes of Candida Species Influences Macrophage Interactions
Frontiers in Cellular and Infection Microbiology, 2020 Candida species are known to differ in their ability to cause infection and have been shown to display varied susceptibilities to antifungal drugs. Treatment with the echinocandin, caspofungin, leads to compensatory alterations in the fungal cell wall ...
Louise A. Walker, Carol A. Munro
doaj +1 more source