Results 1 to 10 of about 13,317 (169)
Recent Insights into the Paradoxical Effect of Echinocandins [PDF]
Journal of Fungi, 2017 Echinocandin antifungals represent one of the most important drug classes for the treatment of invasive fungal infections. The mode of action of the echinocandins relies on inhibition of the β-1,3-glucan synthase, an enzyme essentially required for the ...
Johannes Wagener, Veronika Loiko
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Adaptative survival of Aspergillus fumigatus to echinocandins arises from cell wall remodeling beyond β−1,3-glucan synthesis inhibition [PDF]
Nature CommunicationsAntifungal echinocandins inhibit the biosynthesis of β−1,3-glucan, a major and essential polysaccharide component of the fungal cell wall. However, the efficacy of echinocandins against the pathogen Aspergillus fumigatus is limited.
Malitha C. Dickwella Widanage +10 more
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Journal of Fungi, 2021 Candiduria is a common nosocomial infection in hospitalized patients, which may progress into life-threatening candidemia. Successful treatment of urosepsis requires early and effective antifungal therapy, while the available agents within three ...
Zuzana Javorova Rihova +2 more
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Thrombosis JournalBackground Echinocandins belong to the fourth generation of antifungals, and there are no systematic studies on their risk in coagulation dysfunction; this study will predict the risk of coagulation dysfunction of echinocandins using the US Food and Drug
Qian Cheng +7 more
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G3: Genes, Genomes, Genetics, 2016 Candida glabrata is an important human fungal pathogen whose incidence continues to rise. Because many clinical isolates are resistant to azole drugs, the drugs of choice to treat such infections are members of the echinocandin family, although there are
Anne G. Rosenwald +8 more
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Candida glabrata Resistance to Echinocandins Associated with FKS Genes Mutations: How Urgent is the Problem? [PDF]
Клиническая микробиология и антимикробная химиотерапия, 2016 The resistance of the systemic Candida infections causative agents is a cornerstone of the selection of an effective therapy. But if before the problem was limited to resistance to azole antifungals, then by now we have enough data about cases of ...
Veselov A.V.
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Review of the guidelines for the treatment and prevention of invasive candidiasis in newborns and children [PDF]
Клиническая микробиология и антимикробная химиотерапия, 2017 nvasive infections caused by Candida species are the most common invasive fungal infections in children of different age groups. Premature neonates, especially newborns with low and extremely low birth-weight, have very high mortality rates, with the ...
Veselov A.V.
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Metabolites, 2020 We reviewed the licensed antifungal drugs and summarized their mechanisms of action, pharmacological profiles, and susceptibility to specific fungi. Approved antimycotics inhibit 1,3-β-d-glucan synthase, lanosterol 14-α-demethylase, protein ...
Jiří Houšť +2 more
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The problem of systemic candidosis after transplantation of solid organs. Review of the literature
Трансплантология (Москва), 2018 The article presents current views on the epidemiology, diagnosis and treatment of candidosis with organ transplantation.
S. V. Zhuravel +2 more
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Frontiers in MicrobiologyBackgroundYeast infections from sterile body fluids are increasingly encountered in tertiary care, yet contemporary links between species ecology, antifungal susceptibility, and patient outcomes remain underdefined.MethodsWe conducted a retrospective ...
Jiaxing Liu +7 more
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