Results 1 to 10 of about 16,636 (201)
Microbiology Spectrum, 2022 Cryptococcus neoformans is a major fungal pathogen that often causes life-threatening meningitis in immunocompromised populations. This yeast pathogen is highly resistant to the echinocandin drug caspofungin.
Robert J. Tancer +4 more
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Antibiotics, 2022 Candida auris is a potential multidrug-resistant pathogen able to cause biofilm-associated outbreaks, where frequently indwelling devices are the source of infections.
Noémi Balla +9 more
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Microorganisms, 2022 Candida albicans is a prevalent fungal pathogen of humans. Understanding the development of decreased susceptibility to ECN drugs of this microbe is of substantial interest, as it is viewed as an intermediate step allowing the formation of FKS1 ...
Farha Husain +4 more
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Evidence supporting a role for mammalian chitinases in efficacy of caspofungin against experimental aspergillosis in immunocompromised rats. [PDF]
PLoS ONE, 2013 Caspofungin, currently used as salvage therapy for invasive pulmonary aspergillosis (IPA), strangely only causes morphological changes in fungal growth in vitro but does not inhibit the growth. In vivo it has good efficacy.
Patricia E B Verwer +6 more
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Frontiers in Microbiology, 2017 Public health problems are associated with device-associated biofilm infections, with Candida albicans being the major fungal pathogen. We previously identified potent antibiofilm combination treatment in which the antifungal plant defensin HsAFP1 is co ...
Tanne L. Cools +15 more
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Cellular apoptosis: An alternative mechanism of action for caspofungin against Candida glabrata [PDF]
Current Medical Mycology, 2019 Background and Purpose: Although the mechanism of action for echinocandins is known, the physiological mechanisms by which these antifungal agents cause cell death via the classical apoptotic pathways are not well-defined yet. Regarding this, the present
Parisa Aryamloo +8 more
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Frontiers in Pharmacology, 2020 Caspofungin is the first echinocandin antifungal agent that licented for pediatric use in invasive candidiasis and aspergillosis. In this study, we evaluated the population pharmacokinetics of caspofungin and investigate appropriate dosing optimization ...
Chang-He Niu +7 more
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Microbiology Spectrum, 2023 Candida albicans is a prevalent opportunistic human fungal pathogen. Echinocandins are first-line drugs for the treatment of invasive candidiasis. Molecular mechanisms of resistance to echinocandins have been extensively studied; however, the effect of ...
Lijun Zheng +5 more
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Management of a case of Candida albicans endogenous endophthalmitis with intravitreal caspofungin
Indian Journal of Ophthalmology, 2017 We report a case of Candida albicans endogenous endophthalmitis treated with intravitreal caspofungin. The patient was a known case of acute lymphoblastic leukemia on chemotherapy and presented to us with features suggestive of endogenous endophthalmitis.
Harshali Manish Yadav +3 more
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Network Modeling Reveals Cross Talk of MAP Kinases during Adaptation to Caspofungin Stress in Aspergillus fumigatus. [PDF]
PLoS ONE, 2015 Mitogen activated protein kinases (MAPKs) are highly conserved in eukaryotic organisms. In pathogenic fungi, their activities were assigned to different physiological functions including drug adaptation and resistance.
Robert Altwasser +7 more
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