Results 21 to 30 of about 13,754 (143)

Management of a case of Candida albicans endogenous endophthalmitis with intravitreal caspofungin

Indian Journal of Ophthalmology, 2017
We report a case of Candida albicans endogenous endophthalmitis treated with intravitreal caspofungin. The patient was a known case of acute lymphoblastic leukemia on chemotherapy and presented to us with features suggestive of endogenous endophthalmitis.
Harshali Manish Yadav, Boben Thomas, Cherian Thampy, Tandava Krishnan Panaknti   +3 more
doaj   +1 more source

Network Modeling Reveals Cross Talk of MAP Kinases during Adaptation to Caspofungin Stress in Aspergillus fumigatus. [PDF]

PLoS ONE, 2015
Mitogen activated protein kinases (MAPKs) are highly conserved in eukaryotic organisms. In pathogenic fungi, their activities were assigned to different physiological functions including drug adaptation and resistance.
Robert Altwasser, Clara Baldin, Jakob Weber, Reinhard Guthke, Olaf Kniemeyer, Axel A Brakhage, Jörg Linde, Vito Valiante   +7 more
doaj   +1 more source

Disseminated candidemia refractory to caspofungin therapy in an infant with extremely low birth weight

Journal of the Formosan Medical Association, 2012
Systemic fungal infections have high morbidity and mortality rates in neonates, especially neonates with an extremely low birth weight (ELBW). Here, we describe a 21-day-old ELBW female infant with an amphotericin B-unresponsive congenital Candida ...
Meng-Ju Li, Po-Ren Hsueh, Chun-Yi Lu, Hung-Chieh Chou, Ping-Ing Lee, Luan-Yin Chang, Li-Min Huang   +6 more
doaj   +1 more source

Deletion of AIF1 but not of YCA1/MCA1 protects Saccharomyces cerevisiae and Candida albicans cells from caspofungin-induced programmed cell death

Microbial Cell, 2014
Caspofungin was the first member of a new class of antifungals called echinocandins to be approved by a drug regulatory authority. Like the other echinocandins, caspofungin blocks the synthesis of β(1,3)-D-glucan of the fungal cell wall by inhibiting the
Christopher Chin, Faith Donaghey, Katherine Helming, Morgan McCarthy, Stephen Rogers, Nicanor Austriaco   +5 more
doaj   +1 more source

Caspofungin-induced β(1,3)-glucan exposure in Candida albicans is driven by increased chitin levels

mBio, 2023
To successfully induce disease, Candida albicans must effectively evade the host immune system. One mechanism used by C. albicans to achieve this is to mask immunogenic β(1,3)-glucan epitopes within its cell wall under an outer layer of mannosylated ...
Andrew S. Wagner, Stephen W. Lumsdaine, Mikayla M. Mangrum, Todd B. Reynolds   +3 more
doaj   +1 more source

Efficacy and safety of caspofungin for patients with hepatic insufficiency

BMC Infectious Diseases, 2022
Background To observe the changes of hepatic function and efficacy of conventional dosage of caspofungin in the treatment of patients with different Child–Pugh scores.
Xiaoyun Ran, Pengfei Wang, An Zhang, Binfei Tang   +3 more
doaj   +1 more source

Aspergillus fumigatus Transcription Factors Involved in the Caspofungin Paradoxical Effect

mBio, 2020
Aspergillus fumigatus is the leading cause of pulmonary fungal diseases. Azoles have been used for many years as the main antifungal agents to treat and prevent invasive aspergillosis.
Clara Valero, Ana Cristina Colabardini, Jéssica Chiaratto, Lakhansing Pardeshi, Patrícia Alves de Castro, Jaire Alves Ferreira Filho, Lilian Pereira Silva, Marina Campos Rocha, Iran Malavazi, Jonas Henrique Costa, Taícia Fill, Mário Henrique Barros, Sarah Sze Wah Wong, Vishukumar Aimanianda, Koon Ho Wong, Gustavo H. Goldman   +15 more
doaj   +1 more source

An expanded cell wall damage signaling network is comprised of the transcription factors Rlm1 and Sko1 in Candida albicans.

PLoS Genetics, 2020
The human fungal pathogen Candida albicans is constantly exposed to environmental challenges impacting the cell wall. Signaling pathways coordinate stress adaptation and are essential for commensalism and virulence.
Marienela Y Heredia, Mélanie A C Ikeh, Deepika Gunasekaran, Karen A Conrad, Sviatlana Filimonava, Dawn H Marotta, Clarissa J Nobile, Jason M Rauceo   +7 more
doaj   +1 more source

Gel Formulations with an Echinocandin for Cutaneous Candidiasis: The Influence of Azone and Transcutol on Biopharmaceutical Features

Gels, 2023
Caspofungin is a drug that is used for fungal infections that are difficult to treat, including invasive aspergillosis and candidemia, as well as other forms of invasive candidiasis.
Noelia Pérez-González, Lupe Carolina Espinoza, María Rincón, Lilian Sosa, Mireia Mallandrich, Joaquim Suñer-Carbó, Nuria Bozal-de Febrer, Ana Cristina Calpena, Beatriz Clares-Naveros   +8 more
doaj   +1 more source

Antifungal susceptibility profiles of otomycosis etiological agents in Ahvaz, Iran [PDF]

Current Medical Mycology, 2020
Background and Purpose: Otomycosis is a secondary ear fungal infection among predisposed individuals in humid conditions. Aspergillus species are the most common etiologic agents of this infection.
Maral Gharaghani, Marzieh Halvaeizadeh, Gholam Ali Jalaee, Simin Taghipoor, Neda Kiasat, Ali Zarei Mahmoudabadi   +5 more
doaj   +1 more source