Results 41 to 50 of about 13,754 (143)

A Mechanosensitive Channel Governs Lipid Flippase-Mediated Echinocandin Resistance in Cryptococcus neoformans

mBio, 2019
Echinocandins show fungicidal activity against common invasive mycoses but are ineffective against cryptococcosis. The underlying mechanism for echinocandin resistance in Cryptococcus neoformans remains poorly understood but has been shown to involve ...
Chengjun Cao, Yina Wang, Seema Husain, Patricia Soteropoulos, Chaoyang Xue   +4 more
doaj   +1 more source

Susceptibility of the Candida haemulonii Complex to Echinocandins: Focus on Both Planktonic and Biofilm Life Styles and a Literature Review

Journal of Fungi, 2020
Candida haemulonii complex (C. haemulonii, C. duobushaemulonii and C. haemulonii var. vulnera) is well-known for its resistance profile to different available antifungal drugs.
Lívia S. Ramos, Laura N. Silva, Marta H. Branquinha, André L. S. Santos   +3 more
doaj   +1 more source

In Vitro Assessment of Antifungal Caspofungin on Leishmania donovani Culture Isolation

Canadian Journal of Infectious Diseases and Medical Microbiology, 2017
Leishmania parasite isolation from the human aspirates is always challenging due to most probability of the fungal contamination and the use of antifungal drug which could support the selective growth of the Leishmania parasite. In this study, we examine
Narayan Raj Bhattarai, Keshav Rai, Suman Rijal, Basudha Khanal   +3 more
doaj   +1 more source

Pharmacology and metabolism of anidulafungin, caspofungin and micafungin in the treatment of invasive candidosis - review of the literature

European Journal of Medical Research, 2011
Echinocandins represent the newest class of antifungal agents. Currently, three echinocandins, anidulafungin, caspofungin and micafungin are licensed for clinical use in various indications.
Kofla G, Ruhnke M
doaj   +1 more source

Efficacy and safety of caspofungin for the treatment of invasive pulmonary aspergillosis in patients with chronic obstructive pulmonary disease

Journal of International Medical Research
Objectives We assessed the efficacy of a 3-week primary or salvage caspofungin regimen in patients with chronic obstructive pulmonary disease (COPD) and concomitant proven or suspected invasive pulmonary aspergillosis (IPA).
Shaoqiang Li, Zhengtu Li, Penglei Wang, Yangqing Zhan, Jiaxing Xie, Feng Ye   +5 more
doaj   +1 more source

The Effects of Holothurin and Caspofungin on the Vaginal Cell Inflammation Parameters of the Rattus norvegicus Strain Post Induction of Candida albicans

Infection and Drug Resistance, 2023
Sri Handayani,1,2 Nurdiana Nurdiana,3 Sri Winarsih,4 Agustina Tri Endharti5 1Doctoral Program of Medical Science Department, Faculty of Medicine, Brawijaya University, Malang, Indonesia; 2Department of Midwifery of Aisyiyah, Institution of Surakarta ...
Handayani S, Nurdiana N, Winarsih S, Tri Endharti A   +3 more
doaj  

Predictors of caspofungin exposure-response relationship: a retrospective cohort study on therapeutic drug monitoring parameters

Frontiers in Pharmacology
IntroductionThis study aimed to characterize the exposure-response relationship of caspofungin through analysis of trough serum concentration (Cmin) associated with clinical efficacy, while identifying clinically determinants of Cmin.MethodsA single ...
Mingwei Meng, Ruhua Wei, Yating Lu, Wen Cao, Kai Mo, Zheng Huang, Yane Qin, Xiaobu Lan   +7 more
doaj   +1 more source

MIC Distributions and Evaluation of Fungicidal Activity for Amphotericin B, Itraconazole, Voriconazole, Posaconazole and Caspofungin and 20 Species of Pathogenic Filamentous Fungi Determined Using the CLSI Broth Microdilution Method

Journal of Fungi, 2017
For filamentous fungi (moulds), species-specific interpretive breakpoints and epidemiological cut-off values (ECVs) have only been proposed for a limited number of fungal species–antifungal agent combinations, with the result that clinical breakpoints ...
Andrew M. Borman, Mark Fraser, Michael D. Palmer, Adrien Szekely, Marian Houldsworth, Zoe Patterson, Elizabeth M. Johnson   +6 more
doaj   +1 more source

Development and Quality Control of a Population Pharmacokinetic Model Library for Caspofungin

Pharmaceutics
Background: Caspofungin is an echinocandin antifungal agent commonly used as the first-line therapy for invasive candidiasis, salvage therapy for invasive aspergillosis, and empirical therapy for presumed fungal infections.
Nuo Xu, Yufei Shi, Yixue Wang, Wenyao Mak, Wenyu Yang, Kar Weng Ng, Yue Wu, Zhijia Tang, Qingfeng He, Gangfeng Yan, Xiaoqiang Xiang, Xiao Zhu   +11 more
doaj   +1 more source

Caspofungin versus anidulafungin in patients with invasive candidiasis: a retrospective study with propensity-score-matched analysis

Therapeutic Advances in Infectious Disease
Background: Echinocandins are recommended as an initial treatment for invasive candidiasis. Although safety and efficacy profiles of both anidulafungin and caspofungin are well established, direct head-to-head comparisons have not been reported before ...
Reem Hasan Elajez, Dana Bakdach, Sara Al Balushi, Ahmed Zaqout, Rand Alattar, Tasneem Abdallah, Waleed Awouda, Godwin Wilson, Walid Al-Wali, Emad Ibrahim, Hussam Alsoub   +10 more
doaj   +1 more source