Results 61 to 70 of about 28,829 (241)

Docking-based virtual screening of known drugs against murE of Mycobacterium tuberculosis towards repurposing for TB. [PDF]

, 2016
Repurposing has gained momentum globally and become an alternative avenue for drug discovery because of its better success rate, and reduced cost, time and issues related to safety than the conventional drug discovery process.
Brindha, Sridharan, Gnanadoss, John Joel, Sundaramurthi, Jagadish Chandrabose, Velmurugan, Devadasan, Vincent, Savariar   +4 more
core   +1 more source

An expanded cell wall damage signaling network is comprised of the transcription factors Rlm1 and Sko1 in Candida albicans.

PLoS Genetics, 2020
The human fungal pathogen Candida albicans is constantly exposed to environmental challenges impacting the cell wall. Signaling pathways coordinate stress adaptation and are essential for commensalism and virulence.
Marienela Y Heredia, Mélanie A C Ikeh, Deepika Gunasekaran, Karen A Conrad, Sviatlana Filimonava, Dawn H Marotta, Clarissa J Nobile, Jason M Rauceo   +7 more
doaj   +1 more source

PD-1 blockade improves survival and fungal clearance, induces pro-inflammatory lung cytokines and synergizes with caspofungin in a pulmonary aspergillosis model.

Journal of Infectious Diseases, 2020
Pharmacological immune checkpoint blockade has revolutionized oncological therapies and its remarkable success has sparked interest in expanding checkpoint inhibitor therapy in infectious diseases.
S. Wurster, P. Robinson, N. Albert, J. Tarrand, Marisa A. Goff, M. Swamydas, Jean K. Lim, M. Lionakis, D. Kontoyiannis   +8 more
semanticscholar   +1 more source

Gel Formulations with an Echinocandin for Cutaneous Candidiasis: The Influence of Azone and Transcutol on Biopharmaceutical Features

Gels, 2023
Caspofungin is a drug that is used for fungal infections that are difficult to treat, including invasive aspergillosis and candidemia, as well as other forms of invasive candidiasis.
Noelia Pérez-González, Lupe Carolina Espinoza, María Rincón, Lilian Sosa, Mireia Mallandrich, Joaquim Suñer-Carbó, Nuria Bozal-de Febrer, Ana Cristina Calpena, Beatriz Clares-Naveros   +8 more
doaj   +1 more source

Oral Cryptococcosis due to Naganishia diffluens in a Patient With Thalassemia: A Case Report and a Literature Review

Journal of Clinical Laboratory Analysis, EarlyView.
Naganishia diffluens, a rare non‐neoformans cryptococcal species, was identified by PCR sequencing as the causative agent of oral cryptococcosis in a 31‐year‐old Iranian man with β‐thalassemia. This case represents the first documented instance of oral infection by N.
Zahra Yahyazadeh, Zeynab Haseli, Javad Javidnia, Mahdi Abastabar, Eisa Nazar, Hosein Jalali, Mohamad Taghi Hedayati, Hossein Karami, Mohsen Nosratabadi, Lotfollah Davoodi, Seyyed Reza Aghili, Maryam Moazeni, Iman Haghani, Hamid Badali   +13 more
wiley   +1 more source

The importance of subclasses of chitin synthase enzymes with myosin-like domains for the fitness of fungi [PDF]

, 2016
Acknowledgements TG and CF are funded by FEDER funds through the Operational Programme Competitiveness Factors – COMPETE and national funds by FCT – Foundation for Science and Technology under the strategic project UID/NEU/04539/2013. C.F. is a recipient
Fernandes, Chantal, Gonçalves, Teresa, Gow, Neil A. R.   +2 more
core   +1 more source

Isavuconazole Versus Caspofungin in the Treatment of Candidemia and Other Invasive Candida Infections: The ACTIVE Trial.

Clinical Infectious Diseases, 2018
BACKGROUND Isavuconazole was compared to caspofungin followed by oral voriconazole in a Phase 3, randomized, double-blind, multinational clinical trial for the primary treatment of patients with candidemia or invasive candidiasis.
B. Kullberg, C. Viscoli, P. Pappas, J. Vázquez, L. Ostrosky-Zeichner, C. Rotstein, J. Sobel, R. Herbrecht, G. Rahav, S. Jaruratanasirikul, P. Chetchotisakd, E. Van Wijngaerden, J. D. De Waele, C. Lademacher, M. Engelhardt, L. Kovanda, R. Croos-Dabrera, Christine Fredericks, G. Thompson   +18 more
semanticscholar   +1 more source

Novel and potent antimicrobial effects of caspofungin on drug-resistant Candida and bacteria

Scientific Reports, 2020
Echinocandins, including caspofungin, micafungin, and anidulafungin, are first-line antifungal agents for the treatment of invasive candidiasis. They exhibit fungicidal activity by inhibiting the synthesis of β-1,3-d-glucan, an essential component of the
Makoto Sumiyoshi, T. Miyazaki, J. Makau, S. Mizuta, Yoshimasa Tanaka, Takeshi Ishikawa, K. Makimura, T. Hirayama, T. Takazono, Tomomi Saijo, H. Yamaguchi, Shintaro Shimamura, Kazuko Yamamoto, Y. Imamura, N. Sakamoto, Y. Obase, K. Izumikawa, K. Yanagihara, S. Kohno, H. Mukae   +19 more
semanticscholar   +1 more source

Phenotypic and Molecular Characterization of Naganishia uzbekistanensis: Diagnostic Challenges and Antifungal Resistance Profile

Journal of Clinical Laboratory Analysis, EarlyView.
The graphical abstract summarizes the laboratory characterization of Naganishia uzbekistanensis strain CY11558. The isolate shows distinct colony morphology, globular yeast cells with a fibrillar surface network under scanning electron microscopy, and a weakly positive cryptococcal antigen reaction.
Xin Fan, Xinfei Chen, Jin Li, Rongchen Dai, Pengjie Hu, Li Gu, Meng Xiao, Xiaomin Yu   +7 more
wiley   +1 more source

Caspofungin Use in Daily Clinical Practice for Treatment of Invasive Aspergillosis: Results of a Prospective Observational Registry

BMC Infectious Diseases, 2010
Background A prospective observational registry assessed real world experience with caspofungin monotherapy or combination therapy for the initial or salvage treatment of proven or probable invasive aspergillosis (IA).
Chandwani Sheenu, Stek Michael, Reichert Dietmar, Shin Wan, Maertens Johan, Egerer Gerlinde, Shivaprakash Malathi, Viscoli Claudio   +7 more
doaj   +1 more source