Results 61 to 70 of about 17,702 (177)

Reasons for Failure of Antifungal-lock Therapy with Caspofungin: Need for Higher Concentrations

, 2017
Antifungal-lock therapy (AfLT) has arrived as an investigational approach for preventing catheter removal with limited clinical evidence of its efficiency.
Gökhan Ceylan, Özlem Sandal, Rana İşgüder, Bengü Demirağ, Hasan Ağın, Gamze Gülfidan, İlker Devrim, Ferhat Sarı   +7 more
core   +1 more source

Comparative efficacy and safety of topical caspofungin 0.5% and voriconazole 1% for fungal keratitis: a pilot clinical trial

Scientific Reports
To compare the efficacy of topical caspofungin 0.5% with topical voriconazole 1% in patients with fungal keratitis. In this pilot clinical trial, thirty-four eyes from 34 patients diagnosed with fungal keratitis, confirmed by positive smear or culture ...
Mehrnaz Atighehchian, Golshan Latifi, Ahmed Shalaby Bardan, Dean Ouano, Siamak Zarei-Ghanavati, Zohreh Abedinifar, Mehran Zarei-Ghanavati   +6 more
doaj   +1 more source

Neurofilament light chain as in vitro and clinical biomarker of vincristine‐induced peripheral neuropathy

British Journal of Clinical Pharmacology, Volume 92, Issue 9, Page 3180-3190, September 2026.
Aims Vincristine‐induced peripheral neuropathy (VIPN) is a common side effect in children and adolescents treated with vincristine. Assessing VIPN, especially in young children, is challenging due to a lack of sensitive tools. This limits our understanding of the nature and risk factors of VIPN. This study aimed to investigate neurofilament light chain
Peter Erik Lotko Pontoppidan, Christian Bach Vase, Christina Mortensen, Liv Andres‐Jensen, Dorte Aalund Olsen, Jonna Skov Madsen, Kjeld Schmiegelow, Rene Mathiasen, Tore Bjerregaard Stage   +8 more
wiley   +1 more source

Independent Risk Factors for Postoperative Intestinal Obstruction and Clinical Outcomes in Simultaneous Pancreas‐Kidney Transplantation Recipients

Organ Medicine, Volume 3, Issue 3, Page 157-170, September 2026.
Intestinal obstruction (IO) is an important but underexplored complication following simultaneous pancreas‐kidney transplantation (SPKT) and is associated with considerable morbidity and both clinical and economic burdens. In this single‐center cohort study, perioperative parameters, including demographic characteristics, surgical variables, and ...
Rongxin Chen, Zebin Guo, Guanghui Li, Jiali Fang, Jialin Wu, Zhuangqiang Fang, Luhao Liu, Zheng Chen   +7 more
wiley   +1 more source

Topical caspofungin for treatment of keratitis caused by Candida albicans in a rabbit model

, 2005
Candida albicans is the most frequent cause of fungal keratitis in temperate regions. Caspofungin has potent activity against Candida spp. in a variety of clinical settings. Little is known, however, about its activity against fungal keratitis.
Sarra, GM, Goldblum, D, Katsoulis, K, Frueh, BE, Zimmerli, S   +4 more
core   +1 more source

Mechanistic Investigations of a Novel Lactam Antifungal Agent Against Candida albicans

APMIS, Volume 134, Issue 9, September 2026.
ABSTRACT Candida albicans presents a major, yet underestimated challenge in clinical settings due to its increased resistance to treatment. This study intended to focus on the utility of a novel proprietary lactam molecule, a quorum sensing (QS) inhibitor, against C. albicans. We assessed isolate susceptibility to lactam treatment. In addition, RNA‐Seq
Hafsa Abduljalil, William Johnston, Mark Butcher, Neil Parry, Joanne O'Keeffe, Yvonne Davies, Gordon Ramage   +6 more
wiley   +1 more source

Insufficient serum caspofungin levels in a paediatric patient on ECMO [PDF]

, 2013
Caspofungin, aechinocandin, is a relatively new lipophilic antifungal drug. Little is known concerning the pharmacokinetics of caspofungin in children. Extracorporeal membrane oxygenation (ECMO) allows prolonged cardiopulmonary support in patients with ...
Wildschut, E.D. (Enno), Koch, B.C.P. (Birgit), Hoog, M. (Matthijs) de, Brüggemann, M. (Monika), Goede, A.L. (Anna) de   +4 more
core   +1 more source

Caspofungin hatásának in vivo vizsgálata Candida glabrata klinikai izolátumok ellen

, 2015
Az echinocandinok elsődlegesen választandó szerek C. glabrata okozta invazív fertőzések esetén, melyeknél még mindig magas a mortalitás. Az echinocandinok farmakodinámiás tulajdonságai miatt a dózisnöveléssel elméletileg jobb klinikai hatékonyság érhető ...
Kovács, Dóra
core  

Central Nervous System Aspergillosis: Advances in Diagnosis, Therapeutics, and Multidisciplinary Management (2026 Update)

Mycoses, Volume 69, Issue 9, September 2026.
ABSTRACT Background Central nervous system (CNS) aspergillosis is a life‐threatening infection with mortality rates exceeding 50%, especially in immunocompromised patients. Significant challenges persist due to limited antifungal drug penetration into the CNS, emerging resistance, and diagnostic delays, despite advancements in therapy and diagnostics ...
Moustafa A. Mansour, Mohamed Wahid, Mohamed A. S. El Molla, Mohamed H. Helmy, Taha Mohammed Adel, Hamdi Nabawi Mostafa   +5 more
wiley   +1 more source

A paradox növekedés in vitro vizsgálata caspofungin jelenlétében Candida albicans klinikai izolátumok ellen

, 2014
A gomba eredetű fertőzések incidenciája az elmúlt évtizedekben jelentősen megemelkedett. Az infekciók többségét a Candida genus tagjai okozzák, közülük máig a leggyakrabban izolált faj a C. albicans.
Szegő, Csilla
core