Results 61 to 70 of about 16,636 (201)

Topical caspofungin for treatment of keratitis caused by Candida albicans in a rabbit model

, 2005
Candida albicans is the most frequent cause of fungal keratitis in temperate regions. Caspofungin has potent activity against Candida spp. in a variety of clinical settings. Little is known, however, about its activity against fungal keratitis.
Sarra, GM, Goldblum, D, Katsoulis, K, Frueh, BE, Zimmerli, S   +4 more
core   +1 more source

Integrated Genomic and Phenotypic Analyses Reveal Convergent Resistance Patterns in Clinical Candida tropicalis Isolates

Mycoses, Volume 69, Issue 5, May 2026.
ABSTRACT Background The incidence of Candida tropicalis isolation is increasing in hospital settings. High azole resistance and mortality rates make it a pathogen that requires further analysis. Methods Fourteen azole resistant Candida glabrata clinical isolates were collected from a Lebanese hospital and analysed through whole genome sequencing for ...
Christy Chedraoui, Nour Fattouh, Setrida El Hachem, Tsolaire Sourenian, Louna El Bitar, Lama El Moheb, Anna‐Souraya Sleiman, Ibrahim Bitar, Rola Husni, Roy A. Khalaf   +9 more
wiley   +1 more source

Infection Complications in Pediatric Patients With Inborn Errors of Immunity After Umbilical Cord Blood Transplantation: A Chinese Single‐Center Study

Transplant Infectious Disease, Volume 28, Issue 3, May/June 2026.
This study reveals that infections are highly prevalent in pediatric IEI patients after umbilical cord blood transplantation, with early‐stage infections and bloodstream infections strongly associated with poorer survival. These findings advocate for risk‐stratified surveillance and preemptive strategies in high‐risk subgroups.
Zhongling Wei, Ping Wang, Wenjin Jiang, Jie Man, Ying Huang, Xiaochuan Wang, Hongsheng Wang, Xiaowen Qian, Xiaowen Zhai   +8 more
wiley   +1 more source

Caspofungin hatásának in vivo vizsgálata Candida glabrata klinikai izolátumok ellen

, 2015
Az echinocandinok elsődlegesen választandó szerek C. glabrata okozta invazív fertőzések esetén, melyeknél még mindig magas a mortalitás. Az echinocandinok farmakodinámiás tulajdonságai miatt a dózisnöveléssel elméletileg jobb klinikai hatékonyság érhető ...
Kovács, Dóra
core  

A Mechanosensitive Channel Governs Lipid Flippase-Mediated Echinocandin Resistance in Cryptococcus neoformans

mBio, 2019
Echinocandins show fungicidal activity against common invasive mycoses but are ineffective against cryptococcosis. The underlying mechanism for echinocandin resistance in Cryptococcus neoformans remains poorly understood but has been shown to involve ...
Chengjun Cao, Yina Wang, Seema Husain, Patricia Soteropoulos, Chaoyang Xue   +4 more
doaj   +1 more source

The Aspergillus fumigatus Phosphoproteome Reveals Roles of High-Osmolarity Glycerol Mitogen-Activated Protein Kinases in Promoting Cell Wall Damage and Caspofungin Tolerance

mBio, 2020
The filamentous fungus Aspergillus fumigatus can cause a distinct set of clinical disorders in humans. Invasive aspergillosis (IA) is the most common life-threatening fungal disease of immunocompromised humans. The mitogen-activated protein kinase (MAPK)
Eliciane Cevolani Mattos, Lilian Pereira Silva, Clara Valero, Patrícia Alves de Castro, Thaila Fernanda dos Reis, Liliane F. C. Ribeiro, Mark R. Marten, Rafael Silva-Rocha, Cauã Westmann, Carlos Henrique Tomich de Paula da Silva, Carlton Anthony Taft, Narjes Al-Furaiji, Michael Bromley, Uffe H. Mortensen, J. Philipp Benz, Neil Andrew Brown, Gustavo H. Goldman   +16 more
doaj   +1 more source

Risk of Acute Kidney Injury Associated With Nephrotoxic Burden in Hospitalized Patients: A Scoping Review

Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 891-904, April 2026.
Limited evidence exists synthesizing the risk of acute kidney injury (AKI) associated with the concomitant administration of multiple nephrotoxic drugs, and even less examining the concept of nephrotoxic burden. The objective of this scoping review was to (1) identify definitions of nephrotoxic burden; (2) methods used to quantify (use of calculations)
Wafa Alatawi, Jessica L. Wallace, Dhakrit Rungkitwattanakul, Britney A. Stottlemyer, Tiffany L. Tran, Melanie Manis Reida, Sandra L. Kane‐Gill   +6 more
wiley   +1 more source

Puupehenone, a Marine-Sponge-Derived Sesquiterpene Quinone, Potentiates the Antifungal Drug Caspofungin by Disrupting Hsp90 Activity and the Cell Wall Integrity Pathway

mSphere, 2020
The cell wall-targeting echinocandin antifungals, although potent and well tolerated, are inadequate in treating fungal infections due to their narrow spectrum of activity and their propensity to induce pathogen resistance.
Siddharth K. Tripathi, Qin Feng, Li Liu, David E. Levin, Kuldeep K. Roy, Robert J. Doerksen, Scott R. Baerson, Xiaomin Shi, Xuewen Pan, Wen-Hui Xu, Xing-Cong Li, Alice M. Clark, Ameeta K. Agarwal   +12 more
doaj   +1 more source

A paradox növekedés in vitro vizsgálata caspofungin jelenlétében Candida albicans klinikai izolátumok ellen

, 2014
A gomba eredetű fertőzések incidenciája az elmúlt évtizedekben jelentősen megemelkedett. Az infekciók többségét a Candida genus tagjai okozzák, közülük máig a leggyakrabban izolált faj a C. albicans.
Szegő, Csilla
core  

Caspofungin Treatment Schedule.

, 2013
Caspofungin Treatment Schedule.
Joris Veltman (431438), Jordan Dimitrakoff (431442), Adam P. Fagin (147181), Theo S. Plantinga (164719), Emeric F. Bojarski (431436), Mihai G. Netea (105648), Alexander Hoischen (195016), Adam C. Strauss (431437), Victor J. Anciano Granadillo (431440), Stephen A. Allsop (431439), Arsani William (431441)   +10 more
core   +1 more source