Results 71 to 80 of about 28,829 (241)

The recommended dosage regimen for caspofungin in patients with higher body weight or hypoalbuminaemia will result in low exposure: Five years of data based on a population pharmacokinetic model and Monte-Carlo simulations

Frontiers in Pharmacology, 2022
Background: To develop a population pharmacokinetic (PPK) model for caspofungin, identify parameters influencing caspofungin pharmacokinetics, and assess the required probability of target attainment (PTA) and cumulative fraction of response (CFR) for ...
Qianting Yang, Tao Zhang, Ying Zhang, Dan Sun, Dan Sun, Xiaowei Zheng, Xiaowei Zheng, Qian Du, Xue Wang, Xue Wang, Xiaoliang Cheng, Jianfeng Xing, Jianfeng Xing, Yalin Dong   +13 more
doaj   +1 more source

Infection Complications in Pediatric Patients With Inborn Errors of Immunity After Umbilical Cord Blood Transplantation: A Chinese Single‐Center Study

Transplant Infectious Disease, EarlyView.
This study reveals that infections are highly prevalent in pediatric IEI patients after umbilical cord blood transplantation, with early‐stage infections and bloodstream infections strongly associated with poorer survival. These findings advocate for risk‐stratified surveillance and preemptive strategies in high‐risk subgroups.
Zhongling Wei, Ping Wang, Wenjin Jiang, Jie Man, Ying Huang, Xiaochuan Wang, Hongsheng Wang, Xiaowen Qian, Xiaowen Zhai   +8 more
wiley   +1 more source

Elevated Vacuolar Uptake of Fluorescently Labeled Antifungal Drug Caspofungin Predicts Echinocandin Resistance in Pathogenic Yeast

ACS Central Science, 2020
Echinocandins are the newest class of antifungal drugs in clinical use. These agents inhibit β-glucan synthase, which catalyzes the synthesis of β-glucan, an essential component of the fungal cell wall, and have a high clinical efficacy and low toxicity.
Qais Z. Jaber, Maayan Bibi, Ewa Ksiezopolska, T. Gabaldón, J. Berman, M. Fridman   +5 more
semanticscholar   +1 more source

An Update on Invasive Fungal Infections in Solid Organ Transplant Recipients

Transplant Infectious Disease, EarlyView.
ABSTRACT Invasive fungal infections (IFI) remain a significant infection‐related complication in solid organ transplant recipients (SOTRs), the incidence of which has not changed overtime. With a focus on studies and data published after 2019, this narrative review provides an update on the epidemiology and prevention of IFIs in SOTRs and highlights ...
Tina Marinelli, Shahid Husain
wiley   +1 more source

Cell wall composition and biofilm formation of azoles-susceptible and -resistant Candida glabrata strains [PDF]

, 2011
In the present study, three strains of Candida glabrata have been investigated to shed light on the mechanisms involved in azole resistance during adherence and biofilm formation.
Vitali, Alberto, Vavala, Elisabetta, Marzano, Valeria, Leone, Claudia, Castagnola, Massimo, Iavarone, Federica, Angiolella, Letizia   +6 more
core   +3 more sources

A Randomized Trial of Caspofungin vs Triazoles Prophylaxis for Invasive Fungal Disease in Pediatric Allogeneic Hematopoietic Cell Transplant.

Journal of the Pediatric Infectious Diseases Society, 2020
BACKGROUND Children and adolescents undergoing allogeneic hematopoietic cell transplantation (HCT) are at high risk for invasive fungal disease (IFD). METHODS This multicenter, randomized, open-label trial planned to enroll 560 children and adolescents
C. Dvorak, B. Fisher, A. Esbenshade, M. Nieder, S. Alexander, W. Steinbach, H. Dang, D. Villaluna, Lu Chen, Micah Skeens, T. Zaoutis, L. Sung   +11 more
semanticscholar   +1 more source

Sus1 Modulates Chromatin Remodeling and Gene Expression via the Cell Wall Integrity Pathway in Saccharomyces cerevisiae

The FASEB Journal, Volume 40, Issue 9, 15 May 2026.
Cell wall stress in yeast triggers transcriptional reprogramming through the CWI pathway. This study identifies Sus1, a subunit of SAGA and TREX‐2, as a key regulator in this process. Sus1 associates with stress‐responsive genes, promoting pre‐initiation complex assembly, chromatin remodeling, and RNA Pol II progression independently of H2B ...
Mónica Pavón‐Vergés, Raúl García, José M. Rodríguez‐Peña, Ana Belén Sanz, Javier Arroyo   +4 more
wiley   +1 more source

Drug-Resistant Candida glabrata Infection in Cancer Patients

Emerging Infectious Diseases, 2014
Cancer patients are at risk for candidemia, and increasing Candida spp. resistance poses an emerging threat. We determined rates of antifungal drug resistance, identified factors associated with resistance, and investigated the correlation between ...
Dimitrios Farmakiotis, Jeffrey J. Tarrand, Dimitrios P. Kontoyiannis   +2 more
doaj   +1 more source

Laryngeal Transplantation in Cancer Patients: Evaluation of Surgical Outcomes and Functional Recovery

MedComm, Volume 7, Issue 5, May 2026.
Our pilot clinical study in laryngeal transplantation achieved divergent outcomes: two cases maintained functional speech/swallowing with around 2 year graft survival and have been ongoing, while two succumbed to sepsis (10mo) and hemorrhagic recurrence (11mo).
Zheng Jiang, Mailudan Ainiwaer, Pengwei Zhao, Yansheng Hu, Xin Yang, Yu Xiong, Bin Zeng, Longhao Wang, Jun Liu, Fei Chen   +9 more
wiley   +1 more source

Titan cell production in Cryptococcus neoformans reshapes the cell wall and capsule composition during infection [PDF]

, 2018
This work was supported by the National Institutes of Health (R01AI080275 and R21AI22352), the NIH Fogarty International Center (R25TW009345), the University of Minnesota Center for Translational Science Institute (UL1TR000114), Wellcome Trust (086827 ...
Gow, Neil A R, Lee, Keunsook, Mukaremera, Liliane, Nielsen, Kirsten, Wagener, Jeanette, Wiesner, D. L.   +5 more
core   +1 more source