Results 51 to 60 of about 17,702 (177)

Caspofungin on ARGET-ATRP grafted PHEMA polymers: enhancement and selectivity of prevention of attachment of Candida albicans [PDF]

, 2017
There is a need for coatings for biomedical devices and implants that can prevent the attachment of fungal pathogens while allowing human cells and tissue to appose without cytotoxicity. Here, the authors study whether a poly(2-hydroxyethylmethacrylate) (
Hans J. Griesser, Michl, T., Griesser, Hans J., Harm-Anton Klok, Kathryn Futrega, Thomas D. Michl, Doran, Michael R., Futrega, K., Klok, H., Mocny, P., Griesser, H., Mocny, Piotr, Giles, C., Coad, Bryan R., Klok, Harm-Anton, Futrega, Kathryn, Coad, B., Bryan R. Coad, Doran, M., Michael R. Doran, Carla Giles, Michl, Thomas D., Giles, Carla, Piotr Mocny   +23 more
core   +1 more source

Caspofungin Use in Daily Clinical Practice for Treatment of Invasive Aspergillosis: Results of a Prospective Observational Registry

BMC Infectious Diseases, 2010
Background A prospective observational registry assessed real world experience with caspofungin monotherapy or combination therapy for the initial or salvage treatment of proven or probable invasive aspergillosis (IA).
Chandwani Sheenu, Stek Michael, Reichert Dietmar, Shin Wan, Maertens Johan, Egerer Gerlinde, Shivaprakash Malathi, Viscoli Claudio   +7 more
doaj   +1 more source

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, Volume 46, Issue 6, Page 1477-1498, November 2026.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

Comparison of caspofungin and amphotericin B for invasive candidiasis.

, 2002
Background: Caspofungin is an echinocandin agent with fungicidal activity against candida species. We performed a double-blind trial to compare caspofungin with amphotericin B deoxycholate for the primary treatment of invasive candidiasis.Methods: We ...
Colombo, A. L., Rotstein, C., Smietana, J., Lupinacci, R., Betts, R., Perfect, J., Mora-Duarte, J., Caspofungin Invasive Candidiasis S, Thompson-Moya, L., Kartsonis, N., Sable, C.   +10 more
core   +1 more source

Drug-Resistant Candida glabrata Infection in Cancer Patients

Emerging Infectious Diseases, 2014
Cancer patients are at risk for candidemia, and increasing Candida spp. resistance poses an emerging threat. We determined rates of antifungal drug resistance, identified factors associated with resistance, and investigated the correlation between ...
Dimitrios Farmakiotis, Jeffrey J. Tarrand, Dimitrios P. Kontoyiannis   +2 more
doaj   +1 more source

Antifungal Dispensing in Denmark: Patterns Across Primary Care, Secondary Care, and Over‐the‐Counter Sectors

APMIS, Volume 134, Issue 10, October 2026.
ABSTRACT Fungal infections pose a significant health burden in Denmark. Increasing global antifungal use and emerging antifungal resistance underscore the need for ongoing characterization of national prescribing trends to inform antifungal stewardship.
Aditya K. Gupta, Elizabeth M. Teasell, Gregory Pellegrino, Vasiliki Economopoulos, Ditte M. L. Saunte   +4 more
wiley   +1 more source

Pharmacokinetics of caspofungin in ICU patients [PDF]

, 2014
OBJECTIVES: Caspofungin is used for treatment of invasive fungal infections. As the pharmacokinetics (PK) of antimicrobial agents in critically ill patients can be highly variable, we set out to explore caspofungin PK in ICU patients.
Burger, D.M., Leeuwen, H.J. van, Muilwijk, E.W., Zanten, A.R. van, Pickkers, P., Lange, D.W. de, Bruggemann, R.J.M., Schouten, J.A., Colbers, A., Verweij, P.E.   +9 more
core   +1 more source

Caspofungin binding to iron compromises its antifungal efficacy against Candida albicans

Communications Biology
Echinocandins, which inhibit the synthesis of β-1,3-D-glucans, essential components of the fungal cell wall, are frontline drugs for invasive fungal infections (IFIs) caused by Candida spp.
Andreia Pedras, Cláudia Malta-Luís, Luís M. P. Lima, Dalila Mil-Homens, Catarina Amaral, Américo G. Duarte, Wilson Antunes, Ana Gaspar-Cordeiro, Ricardo O. Louro, Pedro Lamosa, Cláudio M. Soares, Diana Lousa, Catarina Pimentel   +12 more
doaj   +1 more source

Peer review of the pesticide risk assessment of the active substance Trichoderma afroharzianum (formerly harzianum) T‐22

EFSA Journal, Volume 24, Issue 10, October 2026.
Abstract The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessments carried out by the competent authorities of the rapporteur Member State, Sweden, and co‐rapporteur Member State, Netherlands, for the pesticide active substance Trichoderma afroharzianum (formerly harzianum) T‐22 are reported.
European Food Safety Authority (EFSA), Fernando Álvarez, Maria Arena, Domenica Auteri, Sofia Batista Leite, Marco Binaglia, Anna Federica Castoldi, Arianna Chiusolo, Angelo Colagiorgi, Mathilde Colas, Federica Crivellente, Chloe De Lentdecker, Isabella De Magistris, Gabriella Fait, Franco Ferilli, German Giner Santonja, Varvara Gouliarmou, Alessio Ippolito, Frederique Istace, Dimitra Kardassi, Aude Kienzler, Anna Lanzoni, Roberto Lava, Renata Leuschner, Alberto Linguadoca, Mariano Lopez Romano, Jochem Louisse, Christopher Lythgo, Oriol Magrans, Iris Mangas, Silvia Mazzega, Andrea Mioč, Ileana Miron, Tunde Molnar, Laura Padovani, Vincenzo Padricello, Martina Panzarea, Juan Manuel Parra Morte, Simone Rizzuto, Miguel Santos, Rositsa Serafimova, Rachel Sharp, Csaba Szentes, Anne Theobald, Manuela Tiramani, Giorgia Vianello, Laura Villamar‐Bouza, Adriana Scattareggia Marchese   +47 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, Volume 600, Issue 17, Page 2579-2614, September 2026.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source