Results 31 to 40 of about 28,829 (241)
Population Pharmacokinetics of Caspofungin and Dose Simulations in Heart Transplant Recipients
Antimicrobial Agents and Chemotherapy, 2022 The effect of heart transplantation (HTx) on the pharmacokinetics (PK) of caspofungin is not well-characterized. The aim of this study was to investigate the population PK of caspofungin in HTx and non-HTx patients and to identify covariates that may ...
Zheng Wu +9 more
semanticscholar +1 more source
bioRxiv, 2021 The in vitro and in vivo efficacy of caspofungin was determined in combination with isavuconazole against Candida auris. Drug–drug interactions were assessed utilising the fractional inhibitory concentration indices (FICIs), the Bliss independence model ...
F. Nagy +7 more
semanticscholar +1 more source
Caspofungin Treatment of Aspergillus fumigatus Results in ChsG-Dependent Upregulation of Chitin Synthesis and the Formation of Chitin-Rich Microcolonies [PDF]
, 2015 Date of Acceptance: 23/07/2015 We thank Gillian Milne for help with electron microscopy, Sophie M. Schäfer for pilot experiments, and Emilia Mellado for strains. All authors acknowledge financial support of Gilead Sciences through Ph.D.
Gow, Neil A R +3 more
core +1 more source
The Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation [PDF]
, 2017 We thank Cowen lab members for helpful discussions. We also thank David Rogers (University of Tennessee) for sharing microarray analysis of the CAS5 homozygous mutant, and Li Ang (University of Macau) for assistance in optimizing the ChIP-Seq experiments.
Andrews, Brenda J +18 more
core +2 more sources
Frontiers in Microbiology, 2017 Public health problems are associated with device-associated biofilm infections, with Candida albicans being the major fungal pathogen. We previously identified potent antibiofilm combination treatment in which the antifungal plant defensin HsAFP1 is co ...
Tanne L. Cools +15 more
doaj +1 more source
Quantitative Analysis of Candida Cell Wall Components by Flow Cytometrywith Triple-Fluorescence Staining [PDF]
, 2017 This work was supported by the European Commission within the FP7 Framework Programme [Fungitect-Grant No 602125]. We also thank Thomas Sauer, Vienna Biocenter Campus (VBC), Austria, for technical support at the FACS facility of the MFPL, Karl Kuchler ...
Gow, N +5 more
core +1 more source
Pharmaceutics, 2021 Treatment of invasive infections caused by Candida auris is challenging due to the limited therapeutic options. The combination of antifungal drugs may be an interesting and feasible approach to be investigated.
Unai Caballero +3 more
semanticscholar +1 more source
Absent in vitro interaction between chloroquine and antifungals against Aspergillus fumigatus [PDF]
, 2017 This work was supported by Medical Mycology Section, Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, the Netherlands.
Seyedmousavi, Seyedmojtaba +3 more
core +1 more source
bioRxiv, 2021 Aspergillus fumigatus is the main causative agent of invasive pulmonary aspergillosis (IPA), a severe disease that affects immunosuppressed patients worldwide.
A. C. Colabardini +14 more
semanticscholar +1 more source
Cellular apoptosis: An alternative mechanism of action for caspofungin against Candida glabrata [PDF]
Current Medical Mycology, 2019 Background and Purpose: Although the mechanism of action for echinocandins is known, the physiological mechanisms by which these antifungal agents cause cell death via the classical apoptotic pathways are not well-defined yet. Regarding this, the present
Parisa Aryamloo +8 more
doaj +1 more source