Results 31 to 40 of about 16,636 (201)

Pharmacodynamic Effects of Simulated Standard Doses of Antifungal Drugs against Aspergillus Species in a New In Vitro Pharmacokinetic/Pharmacodynamic Model [PDF]

, 2011
In conventional MIC tests, fungi are exposed to constant drug concentrations, whereas in vivo, fungi are exposed to changing drug concentrations.
Thomas J. Walsh, Emmanuel Roilides, Aristea Velegraki, Walsh, Thomas, Zerva, Loukia, Meletiadis, Joseph, Joseph Meletiadis, Roilides, Emmanuel, Rafal Al-Saigh, Velegraki, Aristea, Loukia Zerva, Al Saigh, Rafal   +11 more
core   +1 more source

Disseminated candidemia refractory to caspofungin therapy in an infant with extremely low birth weight

Journal of the Formosan Medical Association, 2012
Systemic fungal infections have high morbidity and mortality rates in neonates, especially neonates with an extremely low birth weight (ELBW). Here, we describe a 21-day-old ELBW female infant with an amphotericin B-unresponsive congenital Candida ...
Meng-Ju Li, Po-Ren Hsueh, Chun-Yi Lu, Hung-Chieh Chou, Ping-Ing Lee, Luan-Yin Chang, Li-Min Huang   +6 more
doaj   +1 more source

Caspofungin-induced β(1,3)-glucan exposure in Candida albicans is driven by increased chitin levels

mBio, 2023
To successfully induce disease, Candida albicans must effectively evade the host immune system. One mechanism used by C. albicans to achieve this is to mask immunogenic β(1,3)-glucan epitopes within its cell wall under an outer layer of mannosylated ...
Andrew S. Wagner, Stephen W. Lumsdaine, Mikayla M. Mangrum, Todd B. Reynolds   +3 more
doaj   +1 more source

Efficacy and safety of caspofungin for patients with hepatic insufficiency

BMC Infectious Diseases, 2022
Background To observe the changes of hepatic function and efficacy of conventional dosage of caspofungin in the treatment of patients with different Child–Pugh scores.
Xiaoyun Ran, Pengfei Wang, An Zhang, Binfei Tang   +3 more
doaj   +1 more source

Ocular penetration of caspofungin in a rabbit uveitis model [PDF]

, 2007
BACKGROUND: Little is known about the ocular penetration of echinocandin antifungals. We studied the ocular distribution of systemically administered caspofungin in a rabbit uveitis model. METHODS: Caspofungin (1 mg/kg per day) was given intravenously to
Zimmerli, Stefan, Goldblum, David, Thormann, Wolfgang, Theurillat, Regula, Fausch, Kathrin, Frueh, Beatrice E   +5 more
core   +1 more source

Aspergillus fumigatus Transcription Factors Involved in the Caspofungin Paradoxical Effect

mBio, 2020
Aspergillus fumigatus is the leading cause of pulmonary fungal diseases. Azoles have been used for many years as the main antifungal agents to treat and prevent invasive aspergillosis.
Clara Valero, Ana Cristina Colabardini, Jéssica Chiaratto, Lakhansing Pardeshi, Patrícia Alves de Castro, Jaire Alves Ferreira Filho, Lilian Pereira Silva, Marina Campos Rocha, Iran Malavazi, Jonas Henrique Costa, Taícia Fill, Mário Henrique Barros, Sarah Sze Wah Wong, Vishukumar Aimanianda, Koon Ho Wong, Gustavo H. Goldman   +15 more
doaj   +1 more source

Caspofungin activity against clinical isolates of azole cross-resistant Candida glabrata overexpressing efflux pump genes

, 2006
OBJECTIVES: Several studies have documented the potent in vitro activity of caspofungin against Candida spp. This is of special concern for Candida glabrata infections that are often resistant to many azole antifungal agents and, consequently, difficult
La Sorda M, Fadda G., Spanu T, Posteraro B, Fiori B, Sanguinetti M   +5 more
core   +1 more source

An expanded cell wall damage signaling network is comprised of the transcription factors Rlm1 and Sko1 in Candida albicans.

PLoS Genetics, 2020
The human fungal pathogen Candida albicans is constantly exposed to environmental challenges impacting the cell wall. Signaling pathways coordinate stress adaptation and are essential for commensalism and virulence.
Marienela Y Heredia, Mélanie A C Ikeh, Deepika Gunasekaran, Karen A Conrad, Sviatlana Filimonava, Dawn H Marotta, Clarissa J Nobile, Jason M Rauceo   +7 more
doaj   +1 more source

Gel Formulations with an Echinocandin for Cutaneous Candidiasis: The Influence of Azone and Transcutol on Biopharmaceutical Features

Gels, 2023
Caspofungin is a drug that is used for fungal infections that are difficult to treat, including invasive aspergillosis and candidemia, as well as other forms of invasive candidiasis.
Noelia Pérez-González, Lupe Carolina Espinoza, María Rincón, Lilian Sosa, Mireia Mallandrich, Joaquim Suñer-Carbó, Nuria Bozal-de Febrer, Ana Cristina Calpena, Beatriz Clares-Naveros   +8 more
doaj   +1 more source

Neurofilament light chain as in vitro and clinical biomarker of vincristine‐induced peripheral neuropathy

British Journal of Clinical Pharmacology, EarlyView.
Aims Vincristine‐induced peripheral neuropathy (VIPN) is a common side effect in children and adolescents treated with vincristine. Assessing VIPN, especially in young children, is challenging due to a lack of sensitive tools. This limits our understanding of the nature and risk factors of VIPN. This study aimed to investigate neurofilament light chain
Peter Erik Lotko Pontoppidan, Christian Bach Vase, Christina Mortensen, Liv Andres‐Jensen, Dorte Aalund Olsen, Jonna Skov Madsen, Kjeld Schmiegelow, Rene Mathiasen, Tore Bjerregaard Stage   +8 more
wiley   +1 more source