Results 31 to 40 of about 13,754 (143)

The recommended dosage regimen for caspofungin in patients with higher body weight or hypoalbuminaemia will result in low exposure: Five years of data based on a population pharmacokinetic model and Monte-Carlo simulations

Frontiers in Pharmacology, 2022
Background: To develop a population pharmacokinetic (PPK) model for caspofungin, identify parameters influencing caspofungin pharmacokinetics, and assess the required probability of target attainment (PTA) and cumulative fraction of response (CFR) for ...
Qianting Yang, Tao Zhang, Ying Zhang, Dan Sun, Dan Sun, Xiaowei Zheng, Xiaowei Zheng, Qian Du, Xue Wang, Xue Wang, Xiaoliang Cheng, Jianfeng Xing, Jianfeng Xing, Yalin Dong   +13 more
doaj   +1 more source

Caspofungin Use in Daily Clinical Practice for Treatment of Invasive Aspergillosis: Results of a Prospective Observational Registry

BMC Infectious Diseases, 2010
Background A prospective observational registry assessed real world experience with caspofungin monotherapy or combination therapy for the initial or salvage treatment of proven or probable invasive aspergillosis (IA).
Chandwani Sheenu, Stek Michael, Reichert Dietmar, Shin Wan, Maertens Johan, Egerer Gerlinde, Shivaprakash Malathi, Viscoli Claudio   +7 more
doaj   +1 more source

Drug-Resistant Candida glabrata Infection in Cancer Patients

Emerging Infectious Diseases, 2014
Cancer patients are at risk for candidemia, and increasing Candida spp. resistance poses an emerging threat. We determined rates of antifungal drug resistance, identified factors associated with resistance, and investigated the correlation between ...
Dimitrios Farmakiotis, Jeffrey J. Tarrand, Dimitrios P. Kontoyiannis   +2 more
doaj   +1 more source

Successful caspofungin treatment of persistent candidemia in extreme prematurity at 23 and 24 weeks' gestation

Journal of the Formosan Medical Association, 2014
Systemic fungal infection continues to be a major cause of mortality in extremely low-birth-weight premature infants. Amphotericin B has been recommended as the primary treatment; however, its use is limited due to drug-induced nephrotoxicity and ...
Ga Won Jeon, Jong Beom Sin
doaj   +1 more source

Caspofungin binding to iron compromises its antifungal efficacy against Candida albicans

Communications Biology
Echinocandins, which inhibit the synthesis of β-1,3-D-glucans, essential components of the fungal cell wall, are frontline drugs for invasive fungal infections (IFIs) caused by Candida spp.
Andreia Pedras, Cláudia Malta-Luís, Luís M. P. Lima, Dalila Mil-Homens, Catarina Amaral, Américo G. Duarte, Wilson Antunes, Ana Gaspar-Cordeiro, Ricardo O. Louro, Pedro Lamosa, Cláudio M. Soares, Diana Lousa, Catarina Pimentel   +12 more
doaj   +1 more source

Culture media influences Candida parapsilosis growth, susceptibility, and virulence

Frontiers in Cellular and Infection Microbiology, 2023
IntroductionCandida parapsilosis, a pathogenic yeast associated with systemic infections, exhibits metabolic adaptability in response to nutrient availability.MethodsWe investigated the impact of RPMI glucose supplemented (RPMId), TSB, BHI and YPD media ...
Betsy V. Arévalo-Jaimes, Betsy V. Arévalo-Jaimes, Joana Admella, Joana Admella, Núria Blanco-Cabra, Núria Blanco-Cabra, Eduard Torrents, Eduard Torrents   +7 more
doaj   +1 more source

Biomarkers of caspofungin resistance in Candida albicans isolates: A proteomic approach

Virulence, 2022
Candida albicans is a clinically important polymorphic fungal pathogen that causes life-threatening invasive infections in immunocompromised patients.
Giuseppe Buda De Cesare, Ahmed Hafez, David Stead, Carlos Llorens, Carol A. Munro   +4 more
doaj   +1 more source

Antifungal Caspofungin Sensitizes MRSA Isolates Towards Zabofloxacin, A Proteomic Study

Journal of Pure and Applied Microbiology, 2020
The incidence of methicillin-resistant Staphylococcus aureus (MRSA) having an increased rate of fluoroquinolone resistance is currently noted in Egypt necessitating the implication of new strategies to restrain the rapid spread of this resistance.
Nelly M. Mohamed, Azza S. Zakaria, Eva A. Edward   +2 more
doaj   +1 more source

Fighting Emerging Caspofungin-Resistant Candida Species: Mitigating Fks1-Mediated Resistance and Enhancing Caspofungin Efficacy by Chitosan

Antibiotics
Invasive candidiasis poses a worldwide threat because of the rising prevalence of antifungal resistance, resulting in higher rates of morbidity and mortality. Additionally, Candida species, which are opportunistic infections, have significant medical and
Aya Tarek, Yasmine H. Tartor, Mohamed N. Hassan, Ioan Pet, Mirela Ahmadi, Adel Abdelkhalek   +5 more
doaj   +1 more source

Stimulation of Eryptosis by Caspofungin

Cellular Physiology and Biochemistry, 2016
Background/Aims: The echinocandin antifungal agent caspofungin has been shown to trigger apoptosis of fungal cells. Beyond that, caspofungin is toxic for host mitochondria.
Thomas Peter, Rosi Bissinger, Florian Lang   +2 more
doaj   +1 more source