Results 31 to 40 of about 17,702 (177)

Disseminated candidemia refractory to caspofungin therapy in an infant with extremely low birth weight

Journal of the Formosan Medical Association, 2012
Systemic fungal infections have high morbidity and mortality rates in neonates, especially neonates with an extremely low birth weight (ELBW). Here, we describe a 21-day-old ELBW female infant with an amphotericin B-unresponsive congenital Candida ...
Meng-Ju Li, Po-Ren Hsueh, Chun-Yi Lu, Hung-Chieh Chou, Ping-Ing Lee, Luan-Yin Chang, Li-Min Huang   +6 more
doaj   +1 more source

Efficacy and safety of caspofungin for patients with hepatic insufficiency

BMC Infectious Diseases, 2022
Background To observe the changes of hepatic function and efficacy of conventional dosage of caspofungin in the treatment of patients with different Child–Pugh scores.
Xiaoyun Ran, Pengfei Wang, An Zhang, Binfei Tang   +3 more
doaj   +1 more source

Caspofungin-induced β(1,3)-glucan exposure in Candida albicans is driven by increased chitin levels

mBio, 2023
To successfully induce disease, Candida albicans must effectively evade the host immune system. One mechanism used by C. albicans to achieve this is to mask immunogenic β(1,3)-glucan epitopes within its cell wall under an outer layer of mannosylated ...
Andrew S. Wagner, Stephen W. Lumsdaine, Mikayla M. Mangrum, Todd B. Reynolds   +3 more
doaj   +1 more source

Ocular penetration of caspofungin in a rabbit uveitis model [PDF]

, 2007
BACKGROUND: Little is known about the ocular penetration of echinocandin antifungals. We studied the ocular distribution of systemically administered caspofungin in a rabbit uveitis model. METHODS: Caspofungin (1 mg/kg per day) was given intravenously to
Zimmerli, Stefan, Goldblum, David, Thormann, Wolfgang, Theurillat, Regula, Fausch, Kathrin, Frueh, Beatrice E   +5 more
core   +2 more sources

Caspofungin activity against clinical isolates of azole cross-resistant Candida glabrata overexpressing efflux pump genes

, 2006
OBJECTIVES: Several studies have documented the potent in vitro activity of caspofungin against Candida spp. This is of special concern for Candida glabrata infections that are often resistant to many azole antifungal agents and, consequently, difficult
La Sorda M, Fadda G., Spanu T, Posteraro B, Fiori B, Sanguinetti M   +5 more
core   +1 more source

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie International Edition, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +1 more source

Toxoplasma gondii Infection After Kidney Transplantation: A Case Report and Literature Review

Organ Medicine, EarlyView.
Toxoplasma gondii infection after kidney transplantation is rare and presents with nonspecific clinical manifestations; however, the associated mortality rate is high. We discuss the relevant literature, clinical manifestations, therapeutic regimens, and prognoses of post‐transplantation toxoplasmosis.
Peng Zhang, Xingqiang Lai, Rongxin Chen, Li Li, Jiali Fang, Guanghui Li, Junjie Ma, Luhao Liu, Zheng Chen   +8 more
wiley   +1 more source

An expanded cell wall damage signaling network is comprised of the transcription factors Rlm1 and Sko1 in Candida albicans.

PLoS Genetics, 2020
The human fungal pathogen Candida albicans is constantly exposed to environmental challenges impacting the cell wall. Signaling pathways coordinate stress adaptation and are essential for commensalism and virulence.
Marienela Y Heredia, Mélanie A C Ikeh, Deepika Gunasekaran, Karen A Conrad, Sviatlana Filimonava, Dawn H Marotta, Clarissa J Nobile, Jason M Rauceo   +7 more
doaj   +1 more source

Long‐term outcomes of haploidentical hematopoietic stem cell transplantation with antithymocyte globulin–based myeloablative conditioning in pediatric refractory or relapsed non‐Hodgkin lymphoma

Pediatric Investigation, EarlyView.
Single‐center retrospective data showed that ATG‐based myeloablative haploidentical hematopoietic stem cell transplantation provides durable remission and favorable long‐term survival in children with refractory/relapsed non‐Hodgkin lymphoma, achieving high engraftment rates, low relapse incidence, and acceptable toxicity.
Chenguang Jia, Jie Zheng, Meng Yuan, Hongbo He, Yibo Fan, Bin Wang, Guanghua Zhu, Jun Yang, Yanhui Luo, Lixiao Cai, Pan Zhang, Yanlong Duan, Maoquan Qin   +12 more
wiley   +1 more source

The siderophore transporter Sit1 is involved in the uptake of caspofungin by Candida albicans

Antimicrobial Agents and Chemotherapy
Invasive infections caused by the yeast Candida albicans are a significant health concern due to their high rates of mortality and morbidity. Current treatment guidelines recommend echinocandin drugs as a primary therapeutic option.
Andreia Pedras, Catarina Amaral, Cristiano Conceição, Cláudia Malta-Luís, Teresa Pissarro, Carolina V. Mariano, Oscar A. Lenis-Rojas, M. Rita Ventura, Catarina Pimentel   +8 more
doaj   +1 more source