Deletion of AIF1 but not of YCA1/MCA1 protects Saccharomyces cerevisiae and Candida albicans cells from caspofungin-induced programmed cell death [PDF]
Microbial Cell, 2014 Caspofungin was the first member of a new class of antifungals called echinocandins to be approved by a drug regulatory authority. Like the other echinocandins, caspofungin blocks the synthesis of β(1,3)-D-glucan of the fungal cell wall by inhibiting the
Christopher Chin +5 more
doaj +2 more sources
Endoplasmic reticulum stress reduces caspofungin resistance in Cryptococcus neoformans [PDF]
mSphereEchinocandin antifungal drugs, such as caspofungin, inhibit β-1,3-glucan synthesis to impair cell wall formation. Caspofungin is effective in the clinic against Aspergillus and Candida species but ineffective against Cryptococcus neoformans, the fungus ...
Xianya Qu +4 more
doaj +2 more sources
Calcineurin‐Dependent Stress Adaptation Enables Caspofungin Heteroresistance Leading to Stable Resistance in Candida Glabrata [PDF]
Advanced Science, Volume 13, Issue 53, 24 September 2026.Caspofungin heteroresistance is prevalent in clinical Candida glabrata isolates and depends on calcineurin‐mediated stress adaptation. This transient phenotype serves as a reservoir for resistance evolution, enabling the emergence of stable resistant descendants under prolonged drug pressure.
Yanyu Su +7 more
wiley +2 more sources
Antifungal Caspofungin Sensitizes MRSA Isolates Towards Zabofloxacin, A Proteomic Study
Journal of Pure and Applied Microbiology, 2020 The incidence of methicillin-resistant Staphylococcus aureus (MRSA) having an increased rate of fluoroquinolone resistance is currently noted in Egypt necessitating the implication of new strategies to restrain the rapid spread of this resistance.
Nelly M. Mohamed +2 more
doaj +2 more sources
Antifungal Susceptibility Profile and Biocide Tolerance in Clinically Relevant Yeasts: Implications for Therapy and Hospital Infection Control [PDF]
Mycoses, Volume 69, Issue 9, September 2026.ABSTRACT Background Opportunistic yeasts account for a substantial proportion of invasive fungal infections and are important agents of healthcare‐associated infections, especially in intensive care units (ICUs). Objectives To describe the clinical and epidemiological characteristics of hospitalized patients with positive cultures for medically ...
Yasmim Passos Lima +8 more
wiley +2 more sources
Stimulation of Eryptosis by Caspofungin
Cellular Physiology and Biochemistry, 2016 Background/Aims: The echinocandin antifungal agent caspofungin has been shown to trigger apoptosis of fungal cells. Beyond that, caspofungin is toxic for host mitochondria.
Thomas Peter +2 more
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AntibioticsInvasive candidiasis poses a worldwide threat because of the rising prevalence of antifungal resistance, resulting in higher rates of morbidity and mortality. Additionally, Candida species, which are opportunistic infections, have significant medical and
Aya Tarek +5 more
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Evidence supporting a role for mammalian chitinases in efficacy of caspofungin against experimental aspergillosis in immunocompromised rats. [PDF]
PLoS ONE, 2013 Caspofungin, currently used as salvage therapy for invasive pulmonary aspergillosis (IPA), strangely only causes morphological changes in fungal growth in vitro but does not inhibit the growth. In vivo it has good efficacy.
Patricia E B Verwer +6 more
doaj +1 more source
Antibiotics, 2022 Candida auris is a potential multidrug-resistant pathogen able to cause biofilm-associated outbreaks, where frequently indwelling devices are the source of infections.
Noémi Balla +9 more
doaj +1 more source
An on-line solid phase extraction procedure for the routine quantification of caspofungin by liquid chromatography-tandem mass spectrometry [PDF]
, 2012 Background: Extensive sets of data are required to investigate the potential use of a therapeutic drug monitoring with individualization of dosage of the antimycotic compound caspofungin.
Rieger, Christina +11 more
core +1 more source