Results 11 to 20 of about 13,754 (143)

Phosphoproteomics of Aspergillus fumigatus Exposed to the Antifungal Drug Caspofungin

mSphere, 2020
Aspergillus fumigatus is an opportunistic and allergenic pathogenic fungus, responsible for fungal infections in humans. A. fumigatus infections are usually treated with polyenes, azoles, or echinocandins.
Eliciane Cevolani Mattos, Giuseppe Palmisano, Gustavo H. Goldman   +2 more
doaj   +1 more source

Synergistic Interaction of Caspofungin Combined with Posaconazole against FKS Wild-Type and Mutant Candida auris Planktonic Cells and Biofilms

Antibiotics, 2022
Candida auris is a potential multidrug-resistant pathogen able to cause biofilm-associated outbreaks, where frequently indwelling devices are the source of infections.
Noémi Balla, Fruzsina Kovács, Bence Balázs, Andrew M. Borman, Aliz Bozó, Ágnes Jakab, Zoltán Tóth, Ola Kobaissi, László Majoros, Renátó Kovács   +9 more
doaj   +1 more source

Development of Antifungal Peptides against Cryptococcus neoformans; Leveraging Knowledge about the cdc50Δ Mutant Susceptibility for Lead Compound Development

Microbiology Spectrum, 2022
Cryptococcus neoformans is a major fungal pathogen that often causes life-threatening meningitis in immunocompromised populations. This yeast pathogen is highly resistant to the echinocandin drug caspofungin.
Robert J. Tancer, Yina Wang, Siddhi Pawar, Chaoyang Xue, Gregory R. Wiedman   +4 more
doaj   +1 more source

Candida albicans Strains Adapted to Caspofungin Due to Aneuploidy Become Highly Tolerant under Continued Drug Pressure

Microorganisms, 2022
Candida albicans is a prevalent fungal pathogen of humans. Understanding the development of decreased susceptibility to ECN drugs of this microbe is of substantial interest, as it is viewed as an intermediate step allowing the formation of FKS1 ...
Farha Husain, Anshuman Yadav, Sudisht K. Sah, Jeffrey J. Hayes, Elena Rustchenko   +4 more
doaj   +1 more source

Evidence supporting a role for mammalian chitinases in efficacy of caspofungin against experimental aspergillosis in immunocompromised rats. [PDF]

PLoS ONE, 2013
Caspofungin, currently used as salvage therapy for invasive pulmonary aspergillosis (IPA), strangely only causes morphological changes in fungal growth in vitro but does not inhibit the growth. In vivo it has good efficacy.
Patricia E B Verwer, Marian T ten Kate, Franco H Falcone, Shaun Morroll, Henri A Verbrugh, Irma A J M Bakker-Woudenberg, Wendy W J van de Sande   +6 more
doaj   +1 more source

A Linear 19-Mer Plant Defensin-Derived Peptide Acts Synergistically with Caspofungin against Candida albicans Biofilms

Frontiers in Microbiology, 2017
Public health problems are associated with device-associated biofilm infections, with Candida albicans being the major fungal pathogen. We previously identified potent antibiofilm combination treatment in which the antifungal plant defensin HsAFP1 is co ...
Tanne L. Cools, Caroline Struyfs, Caroline Struyfs, Jan W. Drijfhout, Soňa Kucharíková, Soňa Kucharíková, Celia Lobo Romero, Celia Lobo Romero, Patrick Van Dijck, Patrick Van Dijck, Marcelo H. S. Ramada, Marcelo H. S. Ramada, Carlos Bloch, Bruno P. A. Cammue, Bruno P. A. Cammue, Karin Thevissen   +15 more
doaj   +1 more source

Population Pharmacokinetics of Caspofungin and Dosing Optimization in Children With Allogeneic Hematopoietic Stem Cell Transplantation

Frontiers in Pharmacology, 2020
Caspofungin is the first echinocandin antifungal agent that licented for pediatric use in invasive candidiasis and aspergillosis. In this study, we evaluated the population pharmacokinetics of caspofungin and investigate appropriate dosing optimization ...
Chang-He Niu, Hua Xu, Liu-Liu Gao, Ying-Ming Nie, Li-Peng Xing, Li-Peng Yu, San-Lan Wu, Yang Wang   +7 more
doaj   +1 more source

Cellular apoptosis: An alternative mechanism of action for caspofungin against Candida glabrata [PDF]

Current Medical Mycology, 2019
Background and Purpose: Although the mechanism of action for echinocandins is known, the physiological mechanisms by which these antifungal agents cause cell death via the classical apoptotic pathways are not well-defined yet. Regarding this, the present
Parisa Aryamloo, Hossein Asgarian-Omran, Narges Aslani, Hadi Hossein-Nataj, Tahereh Shokohi, Hamid Badali, Mojtaba Nabili, Atefeh Abdollahi Gohar, Maryam Moazeni   +8 more
doaj   +1 more source

Susceptibility to caspofungin is regulated by temperature and is dependent on calcineurin in Candida albicans

Microbiology Spectrum, 2023
Candida albicans is a prevalent opportunistic human fungal pathogen. Echinocandins are first-line drugs for the treatment of invasive candidiasis. Molecular mechanisms of resistance to echinocandins have been extensively studied; however, the effect of ...
Lijun Zheng, Yi Xu, Chen Wang, Feng Yang, Yubo Dong, Liangsheng Guo   +5 more
doaj   +1 more source

Caspofungin

Reactions Weekly, 2009
Caspofungin is a new antifungal drug meant for intravenous use. It has been shown to be comparable to other antifungal agents such as amphotericin B and fluconazole for empirical therapy in febrile neutropenic patients, oropharyngeal/esophageal candidiasis and invasive aspergillosis.
Ankit, Parakh, Anand Prakash, Dubey, Debopam, Samanta   +2 more
  +5 more sources