Results 11 to 20 of about 16,636 (201)

Cost-utility analysis of caspofungin and fluconazole for primary treatment of invasive candidiasis and candidemia in Ethiopia

BMC Health Services Research, 2022
Background Invasive candidiasis and/or candidemia (IC/C) is a common fungal infection leading to significant health and economic losses worldwide. Caspofungin was shown to be more effective than fluconazole in treating inpatients with IC/C. However, cost-
Gebremedhin Beedemariam Gebretekle, Atalay Mulu Fentie, Girma Tekle Gebremariam, Eskinder Eshetu Ali, Daniel Asfaw Erku, Tinsae Alemayehu, Workeabeba Abebe, Beate Sander   +7 more
doaj   +2 more sources

Deletion of AIF1 but not of YCA1/MCA1 protects Saccharomyces cerevisiae and Candida albicans cells from caspofungin-induced programmed cell death

Microbial Cell, 2014
Caspofungin was the first member of a new class of antifungals called echinocandins to be approved by a drug regulatory authority. Like the other echinocandins, caspofungin blocks the synthesis of β(1,3)-D-glucan of the fungal cell wall by inhibiting the
Christopher Chin, Faith Donaghey, Katherine Helming, Morgan McCarthy, Stephen Rogers, Nicanor Austriaco   +5 more
doaj   +3 more sources

Antifungal Caspofungin Sensitizes MRSA Isolates Towards Zabofloxacin, A Proteomic Study

Journal of Pure and Applied Microbiology, 2020
The incidence of methicillin-resistant Staphylococcus aureus (MRSA) having an increased rate of fluoroquinolone resistance is currently noted in Egypt necessitating the implication of new strategies to restrain the rapid spread of this resistance.
Nelly M. Mohamed, Azza S. Zakaria, Eva A. Edward   +2 more
doaj   +2 more sources

Stimulation of Eryptosis by Caspofungin

Cellular Physiology and Biochemistry, 2016
Background/Aims: The echinocandin antifungal agent caspofungin has been shown to trigger apoptosis of fungal cells. Beyond that, caspofungin is toxic for host mitochondria.
Thomas Peter, Rosi Bissinger, Florian Lang   +2 more
doaj   +2 more sources

Comparative efficacy and safety of topical caspofungin 0.5% and voriconazole 1% for fungal keratitis: a pilot clinical trial [PDF]

Scientific Reports
To compare the efficacy of topical caspofungin 0.5% with topical voriconazole 1% in patients with fungal keratitis. In this pilot clinical trial, thirty-four eyes from 34 patients diagnosed with fungal keratitis, confirmed by positive smear or culture ...
Mehrnaz Atighehchian, Golshan Latifi, Ahmed Shalaby Bardan, Dean Ouano, Siamak Zarei-Ghanavati, Zohreh Abedinifar, Mehran Zarei-Ghanavati   +6 more
doaj   +2 more sources

Fighting Emerging Caspofungin-Resistant Candida Species: Mitigating Fks1-Mediated Resistance and Enhancing Caspofungin Efficacy by Chitosan

Antibiotics
Invasive candidiasis poses a worldwide threat because of the rising prevalence of antifungal resistance, resulting in higher rates of morbidity and mortality. Additionally, Candida species, which are opportunistic infections, have significant medical and
Aya Tarek, Yasmine H. Tartor, Mohamed N. Hassan, Ioan Pet, Mirela Ahmadi, Adel Abdelkhalek   +5 more
doaj   +2 more sources

<i>Candida glabrata</i> Isolated From Tubo-Ovarian Abscess Cultures in Two Immunocompetent Patients. [PDF]

Clin Case Rep
Persistent 7.3 × 5.8 cm TOA unresponsive to 4 weeks of antibiotic treatment and percutaneous drainage, growing Candida glabrata on cultures. ABSTRACT In this clinical case report, we present two immunocompetent patients with tubo‐ovarian abscesses (TOAs) that were positive for Candida glabrata.
Hirsch M, DePaola R, Eisenberg J, Shay A, Moore TM, Katz A, Stein RA.   +6 more
europepmc   +2 more sources

In vitro synergistic antifungal activities of caspofungin in combination with fluconazole or voriconazole against Candida species determined by the Etest method

International Journal of Infectious Diseases, 2022
Objectives: Increased resistance of Candida species, especially Candida. glabrata is problematic. Combination antifungal therapies were studied to solve the problem.
Qianting Yang, Zhiyong Liu, Yan Wang, Jiao Xie, Kanghuai Zhang, Yalin Dong, Yun F. Wang   +6 more
doaj   +1 more source

Synergistic Activity of the Human Lactoferricin-Derived Peptide hLF1-11 in Combination with Caspofungin against Candida Species

Microbiology Spectrum, 2022
Candida species are the main fungal opportunistic pathogens causing systemic infections that are often associated with drug resistance and biofilm production on medical devices.
Roberta Fais, Cosmeri Rizzato, Iacopo Franconi, Arianna Tavanti, Antonella Lupetti   +4 more
doaj   +1 more source

Assessment of Caspofungin use at a Tertiary Teaching Hospital and compliance with IDSA guidelines and FDA labelings

Saudi Pharmaceutical Journal, 2022
Objective: The aim of this study is to evaluate the utilization pattern of Caspofungin in an academic tertiary care hospital in Riyadh, Saudi Arabia. Methods: This is a retrospective study, conducted at King Saud University Medical City, Riyadh, Saudi ...
Abrar F. Alshehri, Thamer A. Almangour, Abdullah A. Alhifany, Abdulaziz Alhossan   +3 more
doaj   +1 more source