Results 1 to 10 of about 100,338 (264)
CycloPepper: a machine learning platform for predicting cyclization outcomes and optimizing synthesis of therapeutic cyclopeptides [PDF]
Nature CommunicationsCyclic peptides exhibit remarkable stability, membrane permeability, and binding affinity, positioning them as promising therapeutics. However, their synthesis, particularly on-resin head-to-tail cyclization, remains challenging, with cyclization site ...
Yourong Pan +5 more
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Pharmaceuticals, 2023 Fungal infections remain a significant concern for human health. The emergence of microbial resistance, the improper use of antimicrobial drugs, and the need for fewer toxic antifungal treatments in immunocompromised patients have sparked substantial ...
Naiera M. Helmy, Keykavous Parang
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Cyclic Peptides in Pipeline: What Future for These Great Molecules?
Pharmaceuticals, 2023 Cyclic peptides are molecules that are already used as drugs in therapies approved for various pharmacological activities, for example, as antibiotics, antifungals, anticancer, and immunosuppressants.
Lia Costa +2 more
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More than skin deep: cyclic peptides as wound healing and cytoprotective compounds
Frontiers in Cell and Developmental Biology, 2023 The prevalence and cost of wounds pose a challenge to patients as well as the healthcare system. Wounds can involve multiple tissue types and, in some cases, become chronic and difficult to treat.
Ying-Chiang J. Lee +3 more
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Comparison of Collisional Fragmentation Pathways of Sodiated and Protonated Cyclic Peptide Analogs [PDF]
Zhipu Xuebao, 2023 Cyclic peptides and their related species have been shown a unique class of molecules characterized by their biological function and structural diversity.
DU Meng-ying1;JIAO Lu-yang1;XU Yi-cheng1;LI Shu-qi1;CUI Yong-liang1;ZHANG Sen1;KONG Xiang-lei1,2,3
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Current Medicinal Chemistry, 2016 For decades the opioid receptors have been an attractive therapeutic target for the treatment of pain. Since the first discovery of enkephalin, approximately a dozen endogenous opioid peptides have been known to produce opioid activity and analgesia, but their therapeutics have been limited mainly due to low blood brain barrier penetration and poor ...
Michael, Remesic +2 more
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Cyclic Peptides for the Treatment of Cancers: A Review
Molecules, 2022 Cyclic peptides have been widely reported to have therapeutic abilities in the treatment of cancer. This has been proven through in vitro and in vivo studies against breast, lung, liver, colon, and prostate cancers, among others.
Dalifa Ramadhani +3 more
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Frontiers in Molecular Biosciences, 2023 Genetically-encoded combinatorial peptide libraries are convenient tools to identify peptides to be used as therapeutics, antimicrobials and functional synthetic biology modules. Here, we report the identification and characterization of a cyclic peptide,
Stefano Rosa +11 more
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CHIMIA, 2021 Proteins with large and flat binding sites as well as protein–protein interactions are considered ' undruggable ' with conventional small-molecule drugs.
Stephanie M. Linker +4 more
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Marine Cyclic Peptides: Antimicrobial Activity and Synthetic Strategies
Marine Drugs, 2022 Oceans are a rich source of structurally unique bioactive compounds from the perspective of potential therapeutic agents. Marine peptides are a particularly interesting group of secondary metabolites because of their chemistry and wide range of ...
Ricardo Ribeiro +3 more
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