Results 31 to 40 of about 202,161 (307)

Cyclo19,31[D-Cys19]-uPA19-31 is a potent competitive antagonist of the interaction of urokinase-type plasminogen activator with its receptor (CD87) [PDF]

, 2001
Urokinase-type plasminogen activator (uPA) represents a central molecule in pericellular proteolysis and is implicated in a variety of physiological and pathophysiological processes such as tissue remodelling, wound healing, tumor invasion, and ...
Arroyo de Prada, Nuria, Bürgle, Markus, Degitz, Klaus, Kellermann, Josef, Kessler, Horst, Magdolen, Viktor, Riemer, Christoph, Schmiedeberg, Niko, Schmitt, Manfred, Schroeck, Florian, Wilhelm, Olaf G.   +10 more
core   +1 more source

Genome sequences of Rhizopogon roseolus, Mariannaea elegans, Myrothecium verrucaria, and Sphaerostilbella broomeana and the identification of biosynthetic gene clusters for fungal peptide natural products

G3: Genes, Genomes, Genetics, 2022
In recent years, a variety of fungal cyclic peptides with interesting bioactivities have been discovered. For many of these peptides, the biosynthetic pathways are unknown and their elucidation often holds surprises.
Eva Vogt, Christopher M Field, Lukas Sonderegger, Markus Künzler   +3 more
doaj   +1 more source

Trypsin inhibition by macrocyclic and open-chain variants of the squash inhibitor MCoTI-II [PDF]

, 2005
MCoTl-I and MCoTl-II from the seeds of Momordica cochinchinensis are inhibitors of trypsin-like proteases and the only known members of the large family of squash inhibitors that are cyclic and contain an additional loop connecting the amino- and the ...
Avrutina, Olga, Diederichsen, Ulf, Gabrijelcic-Geiger, Dusica, Kolmar, Harald, Le Nguyen, Dung, Schmoldt, Hans-Ulrich, Sommerhoff, Christian P.   +6 more
core   +1 more source

Presence of short and cyclic peptides in Acacia and Ziziphus honeys may potentiate their medicinal values

Open Chemistry, 2021
Acacia honey is characterized by high nutritional, antioxidant, antibacterial and immuno-modulatory values. This work investigated the presence of short and cyclic peptides in Acacia and Ziziphus honey samples.
ALaerjani Wed Mohammed Ali, Abu-Melha Saraa Abdullah, Khan Khalid Ali, Ghramh Hamed A., Alalmie Ali Yahya A., Alshareef Rahaf Mohammed Hussein, AL-Shehri Badria M., Mohammed Mohammed Elimam Ahamed   +7 more
doaj   +1 more source

Molecular model for the self-assembly of the cyclic lipodepsipeptide pseudodesmin A [PDF]

, 2019
Self-assembly of peptides into supramolecular structures represents an active field of research with potential applications ranging from material science to medicine.
Crowet, Jean-Marc, Deleu, Magali, Fehér, Krisztina, Laurin, Yoann, Lins, Laurence, Martins, José, Sinnaeve, Davy   +6 more
core   +4 more sources

Peptídeos cíclicos de biomassa vegetal: características, diversidade, biossíntese e atividades biológicas Cyclic peptide from plant biomass: chemical features and diversity, biosynthesis and biological activities

Química Nova, 2009
Natural peptides are outstanding as the most promising macromolecules in the search for new drugs, especially those of cyclic nature. The higher plants revealed a very peculiar composition of their cyclic peptides, which distinguish themselves by a "head-
Douglas Gatte Picchi, Wanessa Fernanda Altei, Mônica Sue Saito, Vanderlan da Silva Bolzani, Eduardo Maffud Cilli   +4 more
doaj   +1 more source

A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells [PDF]

, 2013
Hypoxia inducible factor-1 (HIF-1) is a heterodimeric transcription factor that acts as the master regulator of cellular response to reduced oxygen levels, thus playing a key role in the adaptation, survival and progression of tumors.
Court, William, Cuda, F., Eccles, Suzanne A., Fox, Keith R., Hoakwie, Franciane, Lawrence, Charlotte, Male, Abigail, Miranda, Elena, Nordgren, Ida, Packham, Graham K., Tavassoli, Ali, Townsend, Paul   +11 more
core   +1 more source

Ternatin and improved synthetic variants kill cancer cells by targeting the elongation factor-1A ternary complex. [PDF]

, 2015
Cyclic peptide natural products have evolved to exploit diverse protein targets, many of which control essential cellular processes. Inspired by a series of cyclic peptides with partially elucidated structures, we designed synthetic variants of ternatin,
Carelli, Jordan D, Jain, Rishi K, Merrick, William C, Miller, Howard R, Ross, Nathan T, Sethofer, Steven G, Simard, Jillian L, Smith, Geoffrey A, Taunton, Jack   +8 more
core   +2 more sources

Rapid selection of cyclic peptides that reduce alpha-synuclein toxicity in yeast and animal models [PDF]

, 2009
Phage display has demonstrated the utility of cyclic peptides as general protein ligands but cannot access proteins inside eukaryotic cells. Expanding a new chemical genetics tool, we describe the first expressed library of head-to-tail cyclic peptides ...
A Ramirez, A Tavassoli, A Tavassoli, A Tavassoli, AA Cooper, AD Gitler, AD Gitler, AM Burja, AR Horswill, AR Horswill, C Cabrele, CP Scott, CP Scott, CW Olanow, DS Wilson, EA Kersteen, EM Driggers, Guy A Caldwell, H van der Putten, H Yu, I Ghosh, J Michael McCaffery, J Winderickx, JF Rual, Joshua A Kritzer, JW Kehoe, Kim A Caldwell, L Burdine, L Cheng, L Ellgaard, LO Nilsson, MBT Bickle, MG Spillantini, MH Polymeropoulos, ML Duennwald, P Sun, PM Abou-Sleiman, R Nass, RR Yocum, S Brenner, S Cao, S Hamamichi, S Hoon, S Li, S Willingham, Sandro Santagata, Shusei Hamamichi, Susan Lindquist, TA Naumann, TC Evans Jr., TF Outeiro, TF Outeiro, TM Kinsella, Todd A Naumann, VMY Lee, Y Ding   +55 more
core   +2 more sources

Sweetening Cyclic Peptide Libraries [PDF]

ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
openaire   +2 more sources