Results 31 to 40 of about 820,776 (296)

Peptídeos cíclicos de biomassa vegetal: características, diversidade, biossíntese e atividades biológicas Cyclic peptide from plant biomass: chemical features and diversity, biosynthesis and biological activities

Química Nova, 2009
Natural peptides are outstanding as the most promising macromolecules in the search for new drugs, especially those of cyclic nature. The higher plants revealed a very peculiar composition of their cyclic peptides, which distinguish themselves by a "head-
Douglas Gatte Picchi, Wanessa Fernanda Altei, Mônica Sue Saito, Vanderlan da Silva Bolzani, Eduardo Maffud Cilli   +4 more
doaj   +1 more source

Cyclic, Cell-Penetrating Peptides Tailor-Made for the Creation of Peptide Libraries with Intrinsic Cell Permeability [PDF]

, 2020
The discovery of high-affinity peptides to many intracellular targets has become feasible through the development of diverse macrocyclic peptide libraries. But lack of cell permeability is a key feature hampering the use of these peptides as therapeutics.
Koushambi, Mitra, Matthew, Hartman, Anthony, Le, Nicolas A., Abrigo, Kaylee, Newcomb, Kara, Dods   +5 more
core   +1 more source

Directed Evolution of Bicyclic Peptides for Therapeutic Application

CHIMIA, 2013
Many naturally occurring cyclic peptides or derivatives thereof are used as therapeutics such as the human hormones vasopressin and oxytocin or the antibiotics vancomycin and daptomycin.
Philippe Diderich, Christian Heinis
doaj   +1 more source

Natural Cyclic Peptides as an Attractive Modality for Therapeutics: A Mini Review

Molecules, 2018
Peptides are important biomolecules which facilitate the understanding of complex biological processes, which in turn could be serendipitous biological targets for future drugs. They are classified as a unique therapeutic niche and will play an important
Muna Ali Abdalla, Lyndy J. McGaw
doaj   +1 more source

Cyclic Tau-derived peptides for stabilization of microtubules [PDF]

The cyclization of peptides is a valuable strategy for the development of binding motifs to target proteins with improved affinity. Microtubules (MTs) are important targets for therapeutics, and a variety of MT-targeted drugs and peptides have recently ...
Matsuura, Kazunori, 00778011, 60283389, イナバ, ヒロシ, Miyake, Kyeongmi Juliano, Kakugo, Akira, 27324, Inaba, Hiroshi, Sada, Kazuki, 27325, マツウラ, カズノリ, Nagata, Miyuu, Kabir, Arif Md. Rashedul, 100000881, 稲葉, 央, 27322, 100001643, 27323, 27321, 4763, 4648, 松浦, 和則   +21 more
core   +1 more source

Macrocylases as synthetic tools for ligand synthesis: enzymatic synthesis of cyclic peptides containing metal-binding amino acids

Royal Society Open Science, 2021
Improving the sustainability of synthesis is a major goal in green chemistry, which has been greatly aided by the development of asymmetric transition metal catalysis.
Richard C. Brewster, Irati Colmenero Labeaga, Catriona E. Soden, Amanda G. Jarvis   +3 more
doaj   +1 more source

Docking Flexible Cyclic Peptides with AutoDock CrankPep [PDF]

, 2019
While a new therapeutic cyclic peptide is approved nearly every year, docking large macrocycles has remained challenging. Here, we present a new version of our peptide docking software AutoDock CrankPep (ADCP), extended to dock peptides cyclized through ...
Yuqi, Zhang, Yuqi Zhang (6824981), Michel, Sanner, Michel Sanner (6904883)   +3 more
core   +2 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Crystal structures of protein-bound cyclic peptides

, 2019
Cyclization is an important post-translational modification of peptides and proteins that confers key advantages such as protection from proteolytic degradation, altered solubility, membrane permeability, bioavailability, and especially restricted ...
Fairlie, David P., Alpeshkumar K. Malde, Timothy A. Hill, Hill, Timothy A., Malde, Alpeshkumar K, Fairlie, David P, Abishek Iyer, Iyer, Abishek, David P. Fairlie, Malde, Alpeshkumar K., Hill, Timothy A   +10 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source