Janus cyclic peptide–polymer nanotubes [PDF]
Nature Communications, 2013 Self-assembled nanotubular structures have numerous potential applications but these are limited by a lack of control over size and functionality. Controlling these features at the molecular level may allow realization of the potential of such structures.
Maarten, Danial +4 more
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On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds. [PDF]
, 2011 Backbone N-methylation is common among peptide natural products and has a substantial impact on both the physical properties and the conformational states of cyclic peptides.
Bauman, Jonathan N +16 more
core +1 more source
Regulation of the G2/M Transition in Rodent Oocytes [PDF]
, 2010 Regulation of maturation in meiotically competent mammalian oocytes is a complex process involving the carefully coordinated exchange of signals between the somatic and germ cell compartments of the ovarian follicle via paracrine and cell–cell coupling ...
Downs, Stephen
core +2 more sources
Three-dimensional Migration of Neurites Is Mediated by Adhesion Site Density and Affinity [PDF]
, 2000 Three-dimensional neurite outgrowth rates within fibrin matrices that contained variable amounts of RGD peptides were shown to depend on adhesion site density and affinity. Bi-domain peptides with a factor XIIIa substrate in one domain and a RGD sequence
Hubbell, Jeffrey A., Schense, Jason C.
core
CAPA neuropeptides and their receptor form an anti-diuretic hormone signalling system in the human disease vector, Aedes aegypti [PDF]
, 2020 Insect CAPA neuropeptides are homologs of mammalian neuromedin U and are known to influence ion and water balance by regulating the activity of the Malpighian ‘renal’ tubules (MTs).
Ber, Lindsay Taylor +7 more
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The Calbindin-D28k binding site on inositol monophosphatase may allow inhibition independent of the lithium site of action [PDF]
, 2011 Among numerous reported biochemical effects the lithium-inhibitable enzyme inositol-monophosphatase (IMPase) remains a viable target for lithium's therapeutic mechanism of action.
Amnon Hoffman +8 more
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Dual-acting stapled peptides target both HIV-1 entry and assembly [PDF]
, 2013 Background: Previously, we reported the conversion of the 12-mer linear and cell-impermeable peptide CAI to a cell-penetrating peptide NYAD-1 by using an i,i + 4 hydrocarbon stapling technique and confirmed its binding to the C-terminal domain (CTD ...
Bhargava, P. +12 more
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Efficient 3D conformer generation of cyclic peptides formed by a disulfide bond
Journal of Cheminformatics, 2022 Cyclic peptides formed by disulfide bonds have been one large group of common drug candidates in drug development. Structural information of a peptide is essential to understand its interaction with its target.
Huanyu Tao +4 more
doaj +1 more source
Cyclic Peptide-Based Sirtuin Substrates [PDF]
Molecules, 2019 In the current study, four side chain-to-side chain cyclic peptides (three 5-mers and one 4-mer) harboring Nε-acetyl-lysine or Nε-myristoyl-lysine were found to be in vitro substrates of the human SIRT1/2/3-catalyzed deacylation with good substrate activities, as judged by the kcat/KM ratios.
Di Chen, Lingling Yan, Weiping Zheng
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Cyclic peptide production using a macrocyclase with enhanced substrate promiscuity and relaxed recognition determinants [PDF]
, 2017 This project was supported by grants from the ERC (no. 339367, MJ), BBSRC IBCatalyst (no. BB/M028526/1, MJ, WEH), BBSRC FoF (no. BB/M013669/1, MJ, WEH), IBioIC Exemplar (no. 2014-2-4, MJ, WEH), an AstraZeneca studentship (MJ, WEH, LT, KR), the Academy of
Alexandru-Crivac, Cristina N. +16 more
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