Results 41 to 50 of about 202,161 (307)

Cyclic Peptides for Drug Development

Angewandte Chemie International Edition, 2023
AbstractCyclic peptides are fascinating molecules abundantly found in nature and exploited as molecular format for drug development as well as other applications, ranging from research tools to food additives. Advances in peptide technologies made over many years through improved methods for synthesis and drug development have resulted in a steady ...
Ji, Xinjian, Nielsen, Alexander L., Heinis, Christian   +2 more
openaire   +2 more sources

Regulation of the G2/M Transition in Rodent Oocytes [PDF]

, 2010
Regulation of maturation in meiotically competent mammalian oocytes is a complex process involving the carefully coordinated exchange of signals between the somatic and germ cell compartments of the ovarian follicle via paracrine and cell–cell coupling ...
Downs, Stephen
core   +2 more sources

Directed Evolution of Bicyclic Peptides for Therapeutic Application

CHIMIA, 2013
Many naturally occurring cyclic peptides or derivatives thereof are used as therapeutics such as the human hormones vasopressin and oxytocin or the antibiotics vancomycin and daptomycin.
Philippe Diderich, Christian Heinis
doaj   +1 more source

Cyclic peptide oral bioavailability: lessons from the past [PDF]

, 2016
Achieving high oral bioavailability for drugs is a key design objective in drug development. It is not surprising then that with the growing expectation of peptides as future drugs, there has also been an increasing interest in developing oral peptide ...
Craik, David J., Wang, Conan K.
core   +1 more source

Natural Cyclic Peptides as an Attractive Modality for Therapeutics: A Mini Review

Molecules, 2018
Peptides are important biomolecules which facilitate the understanding of complex biological processes, which in turn could be serendipitous biological targets for future drugs. They are classified as a unique therapeutic niche and will play an important
Muna Ali Abdalla, Lyndy J. McGaw
doaj   +1 more source

Truncated and Helix-Constrained Peptides with High Affinity and Specificity for the cFos Coiled-Coil of AP-1 [PDF]

, 2013
Protein-based therapeutics feature large interacting surfaces. Protein folding endows structural stability to localised surface epitopes, imparting high affinity and target specificity upon interactions with binding partners.
A Patgiri, B Ibarra-Molero, BN Bullock, BR Brooks, BW Ozanne, CN Pace, D Aud, D Derossi, D Krylov, D Seebach, D Wang, D Wang, D Wang, D Wang, DA Guarracino, David P. Fairlie, DH Appella, DP Fairlie, DP Fairlie, E Vives, EF Wagner, EK O’Shea, EK O’Shea, EK O’Shea, F Bernal, F Bernal, GH Bird, GH Bird, Gloria Ruiz-Gómez, Huy N. Hoang, J Liu, JD Tyndall, JK Judice, JM Dixon, JM Mason, JM Mason, JM Mason, JM Mason, JN Glover, Jody M. Mason, Jose M. Sanchez-Ruiz, LD Walensky, LD Walensky, LK Henchey, LM Johnson, NE Shepherd, NE Shepherd, NE Shepherd, P Lavigne, PS Kutchukian, R Eferl, R Zenz, RE Moellering, RN Chapman, RO Crooks, RS Harrison, S Baek, SM Fuchs, T Wiseman, TA Libermann, Tara Rao, Timothy A. Hill, YW Kim, YW Kim   +63 more
core   +3 more sources

Methionine epimerization in cyclic peptides

RSC Advances, 2021
One step regioselective methionine epimerization in cyclic peptides followed by selective functionalization leads to chemical novelty.
Pramodkumar D. Jadhav, Jianheng Shen, Peta-Gaye Burnett, Jian Yang, Ramaswami Sammynaiken, Martin J. T. Reaney   +5 more
openaire   +3 more sources

Macrocylases as synthetic tools for ligand synthesis: enzymatic synthesis of cyclic peptides containing metal-binding amino acids

Royal Society Open Science, 2021
Improving the sustainability of synthesis is a major goal in green chemistry, which has been greatly aided by the development of asymmetric transition metal catalysis.
Richard C. Brewster, Irati Colmenero Labeaga, Catriona E. Soden, Amanda G. Jarvis   +3 more
doaj   +1 more source

Efficient Monte Carlo Methods for Cyclic Peptides

, 1999
We present a new, biased Monte Carlo scheme for simulating complex, cyclic peptides. Backbone atoms are equilibrated with a biased rebridging scheme, and side-chain atoms are equilibrated with a look-ahead configurational bias Monte Carlo.
Deem, Michael W., Wu, Minghong G.
core   +4 more sources

Absolute proteomic quantification reveals design principles of sperm flagellar chemosensation [PDF]

, 2019
© The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Troetschel, C., Hamzeh, H., Alvarez, L., Pascal, R., Lavryk, F., Boenigk, W., Koerschen, H.
Alvarez, Luis, Bönigk, Wolfgang, Gui, Long, Hamzeh, Hussein, Kaupp, U. Benjamin, Körschen, Heinz Gerd, Lavryk, Fedir, Müller, Astrid, Nicastro, Daniela, Pascal, René, Poetsch, Ansgar, Rennhack, Andreas, Seifert, Reinhard, Strünker, Timo, Trotschel, Christian   +14 more
core   +1 more source