Cyclic Peptides in Pipeline: What Future for These Great Molecules?
Pharmaceuticals, 2023 Cyclic peptides are molecules that are already used as drugs in therapies approved for various pharmacological activities, for example, as antibiotics, antifungals, anticancer, and immunosuppressants.
Lia Costa +2 more
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Cyclic Peptides for the Treatment of Cancers: A Review
Molecules, 2022 Cyclic peptides have been widely reported to have therapeutic abilities in the treatment of cancer. This has been proven through in vitro and in vivo studies against breast, lung, liver, colon, and prostate cancers, among others.
Dalifa Ramadhani +3 more
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Investigation of cyclic peptides as drug delivery systems for the delivery of the anti-tuberculosis drug pyrazinamide [PDF]
Nanoscale AdvancesOne of the important goals of drug delivery in the treatment of diseases is to effectively deliver drugs to deep and inaccessible areas of tissues. In recent years, cyclic peptides (CPs) have been used as drug delivery systems due to their high affinity ...
Batoul Makiabadi +3 more
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Bioinformatics-Assisted Discovery of Antioxidant Cyclic Peptides from Corn Gluten Meal [PDF]
FoodsUsing a multidisciplinary approach, this paper was designed to prepare, identify, and characterize novel maize antioxidant cyclic peptides from protein hydrolysate of corn gluten meal (CGM).
Hongcheng Liu +8 more
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C2PO: an ML-powered optimizer of the membrane permeability of cyclic peptides through chemical modification [PDF]
Journal of CheminformaticsPeptide drug development is currently receiving due attention as a modality between small and large molecules. Therapeutic peptides represent an opportunity to achieve high potency, selectivity, and reach intracellular targets.
Roy Aerts +6 more
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Natural Cyclic Peptides: Synthetic Strategies and Biomedical Applications [PDF]
BiomedicinesNatural cyclic peptides, a diverse class of bioactive compounds, have been isolated from various natural sources and are renowned for their extensive structural variability and broad spectrum of medicinal properties.
Devan Buchanan +3 more
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Chemical Properties, Preparation, and Pharmaceutical Effects of Cyclic Peptides from Pseudostellaria heterophylla [PDF]
MoleculesRadix Pseudostellariae (Tai-Zi-Shen), the dried tuberous root of the Caryophyllaceae plant Pseudostellaria heterophylla (Miq.) Pax (P. heterophylla), has been widely used in traditional Chinese medicine (TCM) for thousands of years. It is slightly bitter,
Yue Yang +6 more
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HighFold-MeD: a Rosetta distillation model to accelerate structure prediction of cyclic peptides with backbone N-methylation and d-amino acids [PDF]
Journal of CheminformaticsAbstract Cyclic peptides with backbone N-methylated amino acids (BNMeAAs) and D-amino acids (D-AAs) have gained increasing attention for their stability, membrane permeability, and other therapeutic potentials.
Zhigang Cao +6 more
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Pharmaceuticals, 2023 Fungal infections remain a significant concern for human health. The emergence of microbial resistance, the improper use of antimicrobial drugs, and the need for fewer toxic antifungal treatments in immunocompromised patients have sparked substantial ...
Naiera M. Helmy, Keykavous Parang
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More than skin deep: cyclic peptides as wound healing and cytoprotective compounds
Frontiers in Cell and Developmental Biology, 2023 The prevalence and cost of wounds pose a challenge to patients as well as the healthcare system. Wounds can involve multiple tissue types and, in some cases, become chronic and difficult to treat.
Ying-Chiang J. Lee +3 more
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