Results 11 to 20 of about 864,219 (292)
Anion recognition by cyclic peptides [PDF]
Chemical Communications, 2015 Cyclic peptides provide excellent scaffolds for anion recognition and improved binding affinity and selectivity has been achieved through peptide backbone rigidification and the introduction of side chains bearing anion recognition groups.
Elmes, Robert B. P. +1 more
openaire +7 more sources
Small Natural Cyclic Peptides from DBAASP Database
PharmaceuticalsAntimicrobial peptides (AMPs) are promising tools for combating microbial resistance. However, their therapeutic potential is hindered by two intrinsic drawbacks—low target affinity and poor in vivo stability.
Evgenia Alimbarashvili +3 more
doaj +2 more sources
A computational study of cyclic peptides with vibrational circular dichroism [PDF]
, 2022 Cyclic peptides are a class of molecules that has shown antimicrobial potential. These are complex compounds to investigate with their large conformational space and multiple chiral centers. A technique that can be used to investigate both conformational
Eikås, Karolina Di Remigio +2 more
core +1 more source
Lessons for Oral Bioavailability: How Conformationally Flexible Cyclic Peptides Enter and Cross Lipid Membranes [PDF]
, 2022 Cyclic peptides are able to extend the druggable space of pharmaceutical targets, due to their size, conformational behavior, and high proportion of hydrogen bond donors and acceptors.
Sereina, Riniker +6 more
core +1 more source
Plant derived cyclic peptides [PDF]
, 2021 Cyclic peptides are widespread throughout the plant kingdom, and display diverse sequences, structures and bioactivities. The potential applications attributed to these peptides and their unusual biosynthesis has captivated the attention of researchers ...
Wilson, David T. +3 more
core +1 more source
Current Medicinal Chemistry, 2016 For decades the opioid receptors have been an attractive therapeutic target for the treatment of pain. Since the first discovery of enkephalin, approximately a dozen endogenous opioid peptides have been known to produce opioid activity and analgesia, but their therapeutics have been limited mainly due to low blood brain barrier penetration and poor ...
Michael, Remesic +2 more
openaire +2 more sources
Comparison of Collisional Fragmentation Pathways of Sodiated and Protonated Cyclic Peptide Analogs [PDF]
Zhipu Xuebao, 2023 Cyclic peptides and their related species have been shown a unique class of molecules characterized by their biological function and structural diversity.
DU Meng-ying1;JIAO Lu-yang1;XU Yi-cheng1;LI Shu-qi1;CUI Yong-liang1;ZHANG Sen1;KONG Xiang-lei1,2,3
doaj +1 more source
Frontiers in Molecular Biosciences, 2023 Genetically-encoded combinatorial peptide libraries are convenient tools to identify peptides to be used as therapeutics, antimicrobials and functional synthetic biology modules. Here, we report the identification and characterization of a cyclic peptide,
Stefano Rosa +11 more
doaj +1 more source
CHIMIA, 2021 Proteins with large and flat binding sites as well as protein–protein interactions are considered ' undruggable ' with conventional small-molecule drugs.
Stephanie M. Linker +4 more
doaj +1 more source
Marine Cyclic Peptides: Antimicrobial Activity and Synthetic Strategies
Marine Drugs, 2022 Oceans are a rich source of structurally unique bioactive compounds from the perspective of potential therapeutic agents. Marine peptides are a particularly interesting group of secondary metabolites because of their chemistry and wide range of ...
Ricardo Ribeiro +3 more
doaj +1 more source