Results 11 to 20 of about 109,209 (296)
Natural Cyclic Peptides: Synthetic Strategies and Biomedical Applications [PDF]
BiomedicinesNatural cyclic peptides, a diverse class of bioactive compounds, have been isolated from various natural sources and are renowned for their extensive structural variability and broad spectrum of medicinal properties.
Devan Buchanan +3 more
doaj +2 more sources
HighFold-MeD: a Rosetta distillation model to accelerate structure prediction of cyclic peptides with backbone N-methylation and d-amino acids [PDF]
Journal of CheminformaticsAbstract Cyclic peptides with backbone N-methylated amino acids (BNMeAAs) and D-amino acids (D-AAs) have gained increasing attention for their stability, membrane permeability, and other therapeutic potentials.
Zhigang Cao +6 more
doaj +2 more sources
The Evolution ofMomordicaCyclic Peptides
Molecular Biology and Evolution, 2014 Cyclic proteins have evolved for millions of years across all kingdoms of life to confer structural stability over their acyclic counterparts while maintaining intrinsic functional properties. Here, we show that cyclic miniproteins (or peptides) from Momordica (Cucurbitaceae) seeds evolved in species that diverged from an African ancestor around 19 Ma.
Mahatmanto, Tunjung +6 more
openaire +6 more sources
Antimicrobial cyclic peptides effectively inhibit multiple forms of Borrelia and cross the blood-brain barrier model [PDF]
Scientific ReportsInfection caused by neuroinvasive Borrelia often manifests long-term CNS disorders and is difficult to treat as most antibiotics fail to attain an effective concentration within the brain or cannot kill the persister forms of Borrelia (cysts and round ...
Evelína Mochnáčová +5 more
doaj +2 more sources
Pharmaceuticals, 2023 Fungal infections remain a significant concern for human health. The emergence of microbial resistance, the improper use of antimicrobial drugs, and the need for fewer toxic antifungal treatments in immunocompromised patients have sparked substantial ...
Naiera M. Helmy, Keykavous Parang
doaj +1 more source
A computational study of cyclic peptides with vibrational circular dichroism [PDF]
, 2022 Cyclic peptides are a class of molecules that has shown antimicrobial potential. These are complex compounds to investigate with their large conformational space and multiple chiral centers. A technique that can be used to investigate both conformational
Eikås, Karolina Di Remigio
core +1 more source
Comparison of Collisional Fragmentation Pathways of Sodiated and Protonated Cyclic Peptide Analogs [PDF]
Zhipu Xuebao, 2023 Cyclic peptides and their related species have been shown a unique class of molecules characterized by their biological function and structural diversity.
DU Meng-ying1;JIAO Lu-yang1;XU Yi-cheng1;LI Shu-qi1;CUI Yong-liang1;ZHANG Sen1;KONG Xiang-lei1,2,3
doaj +1 more source
More than skin deep: cyclic peptides as wound healing and cytoprotective compounds
Frontiers in Cell and Developmental Biology, 2023 The prevalence and cost of wounds pose a challenge to patients as well as the healthcare system. Wounds can involve multiple tissue types and, in some cases, become chronic and difficult to treat.
Ying-Chiang J. Lee +3 more
doaj +1 more source
Anion recognition by cyclic peptides [PDF]
Chemical Communications, 2015 Cyclic peptides provide excellent scaffolds for anion recognition and improved binding affinity and selectivity has been achieved through peptide backbone rigidification and the introduction of side chains bearing anion recognition groups.
Elmes, Robert B. P. +1 more
openaire +5 more sources
Frontiers in Molecular Biosciences, 2023 Genetically-encoded combinatorial peptide libraries are convenient tools to identify peptides to be used as therapeutics, antimicrobials and functional synthetic biology modules. Here, we report the identification and characterization of a cyclic peptide,
Stefano Rosa +11 more
doaj +1 more source