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Pharmaceuticals, 2013 The rapid increase in drug-resistant infections has presented a serious challenge to antimicrobial therapies. The failure of the most potent antibiotics to kill “superbugs” emphasizes the urgent need to develop other control agents. Here we review the history and new development of antimicrobial peptides (AMPs), a growing class of natural and synthetic
Ali Adem Bahar, Dacheng Ren
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Current Biology, 2016 Antimicrobial peptides and proteins (AMPs) are a diverse class of naturally occurring molecules that are produced as a first line of defense by all multicellular organisms. These proteins can have broad activity to directly kill bacteria, yeasts, fungi, viruses and even cancer cells.
Zhang, Ling-juan, Gallo, Richard L.
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Antimicrobial Peptides in Action [PDF]
Journal of the American Chemical Society, 2006 Molecular dynamics simulations of the magainin MG-H2 peptide interacting with a model phospholipid membrane have been used to investigate the mechanism by which antimicrobial peptides act. Multiple copies of the peptide were randomly placed in solution close to the membrane.
Leontiadou, H. +2 more
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Antimicrobial Peptides in 2014 [PDF]
Pharmaceuticals, 2015 This article highlights new members, novel mechanisms of action, new functions, and interesting applications of antimicrobial peptides reported in 2014. As of December 2014, over 100 new peptides were registered into the Antimicrobial Peptide Database, increasing the total number of entries to 2493.
Guangshun Wang +5 more
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Antimicrobial peptides and pregnancy [PDF]
Reproduction, 2011 Abstract Antimicrobial peptides (AMPs) are small proteins produced by epithelial surfaces and inflammatory cells, which have broad-spectrum antimicrobial and immunomodulatory activities. They are known to be important in a number of infectious and inflammatory conditions and have been shown to be present in a number of sites ...
Lorraine, Frew, Sarah J, Stock
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Plant antimicrobial peptides [PDF]
Folia Microbiologica, 2013 Plant antimicrobial peptides (AMPs) are a component of barrier defense system of plants. They have been isolated from roots, seeds, flowers, stems, and leaves of a wide variety of species and have activities towards phytopathogens, as well as against bacteria pathogenic to humans.
Nawrot, Robert +5 more
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Upsala Journal of Medical Sciences, 2014 With increasing antibiotics resistance, there is an urgent need for novel infection therapeutics. Since antimicrobial peptides provide opportunities for this, identification and optimization of such peptides have attracted much interest during recent years.
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Targeted Antimicrobial Peptides [PDF]
Frontiers in Immunology, 2012 The existence of natural antimicrobial substances, contributing to the mechanisms of host defenses, has been recognized since the late nineteenth century. In 1963, the in vitro antibacterial activity of leukocyte extracts was attributed to basic proteins.
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Worms’ Antimicrobial Peptides [PDF]
Marine Drugs, 2019 Antimicrobial peptides (AMPs) are natural antibiotics produced by all living organisms. In metazoans, they act as host defense factors by eliminating microbial pathogens. But they also help to select the colonizing bacterial symbionts while coping with specific environmental challenges.
Renato, Bruno +12 more
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Russian Journal of Genetics: Applied Research, 2013 Antimicrobial peptides (AMPs) are low-molecular-weight defense polypeptides, produced in all living organisms either constitutively or upon perception of signals from pathogenic microorganisms. They are important components of the immune system in both animals and plants. AMPs differ in structure and mode of action. Most of them belong to cysteine-rich
T. I. Odintsova +7 more
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