Results 41 to 50 of about 801,510 (301)

Serum stabilities of short tryptophan- and arginine-rich antimicrobial peptide analogs. [PDF]

PLoS ONE, 2010
Several short antimicrobial peptides that are rich in tryptophan and arginine residues were designed with a series of simple modifications such as end capping and cyclization.
Leonard T Nguyen, Johnny K Chau, Nicole A Perry, Leonie de Boer, Sebastian A J Zaat, Hans J Vogel   +5 more
doaj   +1 more source

Antimicrobial Peptides in Reptiles

Pharmaceuticals, 2014
Reptiles are among the oldest known amniotes and are highly diverse in their morphology and ecological niches. These animals have an evolutionarily ancient innate-immune system that is of great interest to scientists trying to identify new and useful ...
Monique L. van Hoek
doaj   +1 more source

Bioinformatic Analysis of 1000 Amphibian Antimicrobial Peptides Uncovers Multiple Length-Dependent Correlations for Peptide Design and Prediction

, 2020
Amphibians are widely distributed on different continents, except for the polar regions. They are important sources for the isolation, purification and characterization of natural compounds, including peptides with various functions.
Guangshun Wang
core   +1 more source

Self-assembly antimicrobial peptide for treatment of multidrug-resistant bacterial infection

Journal of Nanobiotechnology
The wide-spreading of multidrug resistance poses a significant threat to human and animal health. Although antimicrobial peptides (AMPs) show great potential application, their instability has severely limited their clinical application.
Xuanxuan Ma, Na Yang, Ruoyu Mao, Ya Hao, Yuanyuan Li, Ying Guo, Da Teng, Yinhua Huang, Jianhua Wang   +8 more
doaj   +1 more source

Enhanced antifouling properties of marine antimicrobial peptides by PEGylation

Frontiers in Bioengineering and Biotechnology, 2023
Covalent immobilisation of antimicrobial peptides (AMPs) on underwater surfaces to combat marine biofouling is of great interest as it is an efficient, broad-spectrum and environmentally friendly strategy.
Tong Lou, Xiuqin Bai, Xiuqin Bai, Xiaoyan He, Xiaoyan He, Wencheng Liu, Zongcheng Yang, Ying Yang, Chengqing Yuan   +8 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Design and Evaluation of Short Bovine Lactoferrin-Derived Antimicrobial Peptides against Multidrug-Resistant Enterococcus faecium

, 2022
Enterococcus faecium has become an important drug-resistant nosocomial pathogen because of widespread antibiotic abuse. We developed short and chemically simple antimicrobial peptides (AMPs) with a selective amino acid composition, fixed charge, and ...
LewisOscar Felix, Murry, Daryl J., Chhonker, Yashpal Singh, Narchonai Ganesan, Mishra, Biswajit, Mylonakis, Eleftherios, Biswajit Mishra, Sai Sundeep Kollala, Ganesan, Narchonai, Anindya Basu, Eleftherios Mylonakis, Basu, Anindya, Yashpal Singh Chhonker, Daryl J. Murry, Felix, LewisOscar, Kollala, Sai Sundeep   +15 more
core   +1 more source

A Uniform In Vitro Efficacy Dataset to Guide Antimicrobial Peptide Design

Data, 2019
Antimicrobial peptides are ubiquitous molecules that form the innate immune system of organisms across all kingdoms of life. Despite their prevalence and early origins, they continue to remain potent natural antimicrobial agents.
Deepesh Nagarajan, Tushar Nagarajan, Neha Nanajkar, Nagasuma Chandra   +3 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source