Results 41 to 50 of about 151,205 (306)

Development and challenges of antimicrobial peptides for therapeutic applications

, 2020
More than 3000 antimicrobial peptides (AMPs) have been discovered, seven of which have been approved by the U.S. Food and Drug Administration (FDA). Now commercialized, these seven peptides have mostly been utilized for topical medications, though some ...
Lu, Timothy K, Timothy K. Lu, Chen, Charles H., Charles H. Chen   +3 more
core   +1 more source

Antimicrobial peptides

Upsala Journal of Medical Sciences, 2014
With increasing antibiotics resistance, there is an urgent need for novel infection therapeutics. Since antimicrobial peptides provide opportunities for this, identification and optimization of such peptides have attracted much interest during recent years.
openaire   +2 more sources

Design and Evaluation of Short Bovine Lactoferrin-Derived Antimicrobial Peptides against Multidrug-Resistant Enterococcus faecium

, 2022
Enterococcus faecium has become an important drug-resistant nosocomial pathogen because of widespread antibiotic abuse. We developed short and chemically simple antimicrobial peptides (AMPs) with a selective amino acid composition, fixed charge, and ...
LewisOscar Felix, Murry, Daryl J., Chhonker, Yashpal Singh, Narchonai Ganesan, Mishra, Biswajit, Mylonakis, Eleftherios, Biswajit Mishra, Sai Sundeep Kollala, Ganesan, Narchonai, Anindya Basu, Eleftherios Mylonakis, Basu, Anindya, Yashpal Singh Chhonker, Daryl J. Murry, Felix, LewisOscar, Kollala, Sai Sundeep   +15 more
core   +1 more source

Polylactic Glycolic Acid-Mediated Delivery of Plectasin Derivative NZ2114 in Staphylococcus epidermidis Biofilms

Antibiotics
Antimicrobial peptides (AMPs) are antibiotic candidates; however, their instability and protease susceptibility limit clinical applications. In this study, the polylactic acid–glycolic acid (PLGA)–polyvinyl alcohol (PVA) drug delivery system was screened
Xuanxuan Ma, Na Yang, Ruoyu Mao, Ya Hao, Da Teng, Yinhua Huang, Jianhua Wang   +6 more
doaj   +1 more source

Performance evaluation of antimicrobial peptide ll-37 and hepcidin and β-defensin-2 secreted by mesenchymal stem cells

Heliyon, 2019
Peptides are secreted by different cell types and are trendy therapeutic agents that have attracted attention for the treatment of several diseases such as infections.
Reza Esfandiyari, Raheleh Halabian, Elham Behzadi, Hamid Sedighian, Ramezan Jafari, Abbas Ali Imani Fooladi   +5 more
doaj   +1 more source

Serum stabilities of short tryptophan- and arginine-rich antimicrobial peptide analogs. [PDF]

PLoS ONE, 2010
Several short antimicrobial peptides that are rich in tryptophan and arginine residues were designed with a series of simple modifications such as end capping and cyclization.
Leonard T Nguyen, Johnny K Chau, Nicole A Perry, Leonie de Boer, Sebastian A J Zaat, Hans J Vogel   +5 more
doaj   +1 more source

Bioinformatic Analysis of 1000 Amphibian Antimicrobial Peptides Uncovers Multiple Length-Dependent Correlations for Peptide Design and Prediction

, 2020
Amphibians are widely distributed on different continents, except for the polar regions. They are important sources for the isolation, purification and characterization of natural compounds, including peptides with various functions.
Guangshun Wang
core   +1 more source

Antimicrobial Peptides and Colitis [PDF]

Current Pharmaceutical Design, 2012
Antimicrobial peptides (AMPs) are important components of innate immunity. They are often expressed in response to colonic inflammation and infection. Over the last several years, the roles of several antimicrobial peptides have been explored. Gene expression of many AMPs (beta defensin HBD2-4 and cathelicidin) is induced in response to invasion of gut
Samantha, Ho, Charalabos, Pothoulakis, Hon Wai, Koon   +2 more
openaire   +2 more sources

Enhanced antifouling properties of marine antimicrobial peptides by PEGylation

Frontiers in Bioengineering and Biotechnology, 2023
Covalent immobilisation of antimicrobial peptides (AMPs) on underwater surfaces to combat marine biofouling is of great interest as it is an efficient, broad-spectrum and environmentally friendly strategy.
Tong Lou, Xiuqin Bai, Xiuqin Bai, Xiaoyan He, Xiaoyan He, Wencheng Liu, Zongcheng Yang, Ying Yang, Chengqing Yuan   +8 more
doaj   +1 more source

A Uniform In Vitro Efficacy Dataset to Guide Antimicrobial Peptide Design

Data, 2019
Antimicrobial peptides are ubiquitous molecules that form the innate immune system of organisms across all kingdoms of life. Despite their prevalence and early origins, they continue to remain potent natural antimicrobial agents.
Deepesh Nagarajan, Tushar Nagarajan, Neha Nanajkar, Nagasuma Chandra   +3 more
doaj   +1 more source