Results 21 to 30 of about 238,096 (231)

Targeted Antimicrobial Peptides [PDF]

Frontiers in Immunology, 2012
The existence of natural antimicrobial substances, contributing to the mechanisms of host defenses, has been recognized since the late nineteenth century. In 1963, the in vitro antibacterial activity of leukocyte extracts was attributed to basic proteins.
openaire   +3 more sources

Wheat antimicrobial peptides

Russian Journal of Genetics: Applied Research, 2013
Antimicrobial peptides (AMPs) are low-molecular-weight defense polypeptides, produced in all living organisms either constitutively or upon perception of signals from pathogenic microorganisms. They are important components of the immune system in both animals and plants. AMPs differ in structure and mode of action. Most of them belong to cysteine-rich
T. I. Odintsova, T. V. Korostyleva, L. L. Utkina, Ya. A. Andreev, A. A. Slavokhotova, E. A. Istomina, V. A. Pukhal’skii, T. A. Egorov   +7 more
openaire   +2 more sources

Destabilization of α-helical structure in solution improves bactericidal activity of antimicrobial peptides: Opposing effects on bacterial and viral targets [PDF]

, 2016
We have previously examined the mechanism of antimicrobial peptides on the outer membrane of vaccinia virus. Here we show that the formulation of peptides LL37 and magainin-2B amide in polysorbate 20 (Tween-20™) results in greater reductions in virus ...
Beck, Konrad, Fox, Marc A., Gumbleton, Mark, Morris, Christopher J., Ulaeto, David O.   +4 more
core   +2 more sources

Free energy barrier for melittin reorientation from a membrane-bound state to a transmembrane state [PDF]

, 2013
An important step in a phospholipid membrane pore formation by melittin antimicrobial peptide is a reorientation of the peptide from a surface into a transmembrane conformation.
Allende D., Almeida P. F., Andersson M., Berneche S., Chen F. Y., Constantinescu I., de Jongh H. H. J., Glattli A., Gordon-Grossman M., Hess B., Hristova K., Huang H. W., Huang H. W., Humphrey W., Irudayam S. J., Irudayam S. J., Jämbeck J. P. M., Klocek G., Kuchinka E., Ladokhin A. S., Lam K. L. H., Lin J. H., Lu N. Y., Manna M., Matsuzaki K., Max L. Berkowitz, Mihajlovic M., Mihajlovic M., Mihajlovic M., Naito A., Nguyen L. T., Pott T., Pott T., Qiu W. H., Raghuraman H., Raghuraman H., Raghuraman H., Raghuraman H., Santo K. P., Sengupta D., Sheeba J. Irudayam, Tobias Pobandt, Torrie G. M., Ulmschneider J. P., Vivcharuk V., Wessman P., Wiedman G., Wimley W. C., Wimley W. C., Yang L., Yeh I. C.   +50 more
core   +3 more sources

Autoregulation of Nisin Biosynthesis in Lactococcus lactis by Signal Transduction [PDF]

, 1995
The post-translationally modified, antimicrobial peptide nisin is secreted by strains of Lactococcus lactis that contain the chromosomally located nisin biosynthetic gene cluster nisABTCIPRKFEG.
Buchman, Casadaban, de Vos, de Vos, Engelke, Engelke, Fukase, Gallo, Gao, Gasson, Goodman, Gross, Gross, Gutowski-Eckel, Holo, Horinouchi, Hurst, Kaletta, Klein, Kuipers, Kuipers, Kuipers, Mattick, Mulders, Parkinson, Peschel, Piard, Piard, Platteeuw, Rauch, Sahl, Sahl, Sahl, Sanger, Schnell, Siegers, Stock, Tanaka, van der Meer, Wakamiya, Wakamiya, Wakamiya, Wanner, Yanisch-Perron   +43 more
core   +2 more sources

In vivo therapeutic efficacy of frog skin-derived peptides against Pseudomonas aeruginosa-induced pulmonary infection [PDF]

, 2017
Pseudomonas aeruginosa is an opportunistic and frequently drug-resistant pulmonary pathogen especially in cystic fibrosis sufferers. Recently, the frog skin-derived antimicrobial peptide (AMP) Esc(1-21) and its diastereomer Esc(1-21)-1c were found to ...
Chen, Chen, Di, Y. Peter, Mangoni, Maria Luisa   +2 more
core   +1 more source

Chain-end modifications and sequence arrangements of antimicrobial peptoids for mediating activity and nano-assembly [PDF]

, 2020
Poly(N-substituted glycine) “peptoids” are an interesting class of peptidomimics that can resist proteolysis and mimic naturally found antimicrobial peptides (AMPs), which exhibit wide spectrum activity against bacteria.
Castelletto, Valeria, Hamley, Ian W., Hasan, Abshar, Lau, King Hang Aaron, Pandey, Lalit M., Ruokolainen, Janne, Saxena, Varun, Sefcik, Jan, Seitsonen, Jani, Zimbitas, Georgina   +9 more
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Antimicrobial peptides

Upsala Journal of Medical Sciences, 2014
With increasing antibiotics resistance, there is an urgent need for novel infection therapeutics. Since antimicrobial peptides provide opportunities for this, identification and optimization of such peptides have attracted much interest during recent years.
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source