Results 1 to 10 of about 1,065,101 (302)

Heuristic energy-based cyclic peptide design. [PDF]

PLoS Computational Biology
Rational computational design is crucial to the pursuit of novel drugs and therapeutic agents. Meso-scale cyclic peptides, which consist of 7-40 amino acid residues, are of particular interest due to their conformational rigidity, binding specificity ...
Qiyao Zhu, Vikram Khipple Mulligan, Dennis Shasha   +2 more
doaj   +2 more sources

Identification of a novel and high-affinity cyclic peptide targeting Keap1 for inflammation treatment by a combined virtual screening strategy [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry
Inhibition of the Keap1-Nrf2 protein-protein interaction with cyclic peptides represents an attractive strategy to treat inflammation. However, the cyclic peptides for this inhibition are constrained by their low affinity. In this study, the peptides 1-6
Shenglin Gao, Xiaokai Shi, Shudan Yang, Yuting Wang, Qian Wang, Minyan Yang   +5 more
doaj   +2 more sources

Machine learning-driven identification of DLL3 as a molecular target and development of a DLL3-binding cyclic peptide for glioblastoma [PDF]

Frontiers in Oncology
BackgroundGlioblastoma (GBM) remains the most aggressive primary brain tumor and is associated with a dismal prognosis despite maximal multimodal therapy.
Dan Xu, Dan Xu, Dan Xu, Daqing Huang, Daqing Huang, Zhijie Li, Yan Yan, Zhencun Cui, Zhongfang Zhao, Zhongfang Zhao, Xiaoju Chen, Maolong Chen, Xiongxiong Liu, Zhaobo Zhou, Qianxi Ni, Taofeng Zhang, Hui Wang, Hui Wang, Hui Wang, Qi Zeng, Xi’an Xiong, Bin Liu, Bin Liu   +22 more
doaj   +2 more sources

MultiCycPermea: accurate and interpretable prediction of cyclic peptide permeability using a multimodal image-sequence model [PDF]

BMC Biology
Background Cyclic peptides, known for their high binding affinity and low toxicity, show potential as innovative drugs for targeting “undruggable” proteins. However, their therapeutic efficacy is often hindered by poor membrane permeability.
Zixu Wang, Yangyang Chen, Yifan Shang, Xiulong Yang, Wenqiong Pan, Xiucai Ye, Tetsuya Sakurai, Xiangxiang Zeng   +7 more
doaj   +2 more sources

Research Progress on Cyclic-Peptide Functionalized Nanoparticles for Tumor-Penetrating Delivery [PDF]

International Journal of Nanomedicine
Chenkai Wang,1,2 Zefan Shen,1,2 Yiyang Chen,1,2 Yifan Wang,2 Xuanyi Zhou,2 Xinyi Chen,1 Yuhang Li,2 Pu Zhang,2 Qi Zhang2 1The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, People’s Republic of China; 2Urology ...
Wang C, Shen Z, Chen Y, Wang Y, Zhou X, Chen X, Li Y, Zhang P, Zhang Q   +8 more
doaj   +2 more sources

A cyclic peptide-based PROTAC induces intracellular degradation of palmitoyltransferase and potently decreases PD-L1 expression in human cervical cancer cells

Frontiers in Immunology, 2023
IntroductionOur previous research has found that degradation of palmitoyltransferase in tumor cells using a linear peptide PROTAC leads to a significant decrease in PD-L1 expression in tumors.
Yu-Ying Shi, Di-Rong Dong, Gang Fan, Meng-Yuan Dai, Miao Liu   +4 more
doaj   +1 more source

The cyclic peptide G4CP2 enables the modulation of galactose metabolism in yeast by interfering with GAL4 transcriptional activity

Frontiers in Molecular Biosciences, 2023
Genetically-encoded combinatorial peptide libraries are convenient tools to identify peptides to be used as therapeutics, antimicrobials and functional synthetic biology modules. Here, we report the identification and characterization of a cyclic peptide,
Stefano Rosa, Andrea Tagliani, Chiara Bertaso, Luca Tadini, Cristina Visentin, Louise Jane Gourlay, Sabrina Pricl, Sabrina Pricl, Lucia Feni, Sara Pellegrino, Paolo Pesaresi, Simona Masiero   +11 more
doaj   +1 more source

Efficient 3D conformer generation of cyclic peptides formed by a disulfide bond

Journal of Cheminformatics, 2022
Cyclic peptides formed by disulfide bonds have been one large group of common drug candidates in drug development. Structural information of a peptide is essential to understand its interaction with its target.
Huanyu Tao, Qilong Wu, Xuejun Zhao, Peicong Lin, Sheng-You Huang   +4 more
doaj   +1 more source

Rapid in silico Design of Potential Cyclic Peptide Binders Targeting Protein-Protein Interfaces

Frontiers in Chemistry, 2020
Rational design of specific inhibitors of protein-protein interactions is desirable for drug design to control cellular signal transduction but also for studying protein-protein interaction networks.
Brianda L. Santini, Martin Zacharias
doaj   +1 more source

Screening technology of cyclic peptide library based on gene encoding

Medicine in Drug Discovery, 2022
As a powerful tool for the discovery of peptide compounds, high-throughput library screening technology can also perform multitarget screening with high chemical diversity as a condition, which accelerates the process of exploring high-affinity peptide ...
Yangqiang Chen, Chonggang Duan, Kai Chen, Shumeng Sun, Daizhou Zhang, Xiangjing Meng   +5 more
doaj   +1 more source