Results 1 to 10 of about 2,011,052 (344)
Rapid in silico Design of Potential Cyclic Peptide Binders Targeting Protein-Protein Interfaces
Frontiers in Chemistry, 2020 Rational design of specific inhibitors of protein-protein interactions is desirable for drug design to control cellular signal transduction but also for studying protein-protein interaction networks.
Brianda L. Santini, Martin Zacharias
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A cyclic peptide inhibitor of the SARS-CoV-2 main protease
European Journal of Medicinal Chemistry, 2021 This paper presents the design and study of a first-in-class cyclic peptide inhibitor against the SARS-CoV-2 main protease (Mpro). The cyclic peptide inhibitor is designed to mimic the conformation of a substrate at a C-terminal autolytic cleavage site ...
Adam G Kreutzer, , Elizabeth M Diessner
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Marine Drugs, 2021 Peptides have a three-dimensional configuration that can adopt particular conformations for binding to proteins, which are well suited to interact with larger contact surface areas on target proteins.
Zhengshuang Xu
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European Journal of Pharmaceutical Sciences, 2022 Peptide ligand modified nanoparticles can simply prepared by post-insertion method to mix pre-formed nanoparticles with peptide-lipid conjugates in an aqueous solution at an optimal temperature. Therefore, water dispersibility of peptide-lipid conjugates
Naoya Kato +2 more
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Cyclic peptide therapeutics: past, present and future
Current Opinion in Chemical Biology, 2017 Cyclic peptides combine several favorable properties such as good binding affinity, target selectivity and low toxicity that make them an attractive modality for the development of therapeutics.
Zorzi, Alessandro +2 more
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Cyclic Peptides for Drug Development
Angewandte Chemie International Edition, 2023 AbstractCyclic peptides are fascinating molecules abundantly found in nature and exploited as molecular format for drug development as well as other applications, ranging from research tools to food additives. Advances in peptide technologies made over many years through improved methods for synthesis and drug development have resulted in a steady ...
Ji, Xinjian +2 more
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Sweetening Cyclic Peptide Libraries [PDF]
ChemInform, 2004 Enzymatic macrolactamization of linear glycosidated peptides provides access to an important class of drug-like molecules. The work presented in this issue [1] shows that it may be possible to make complex libraries of glycosidated cyclic peptides by ...
Christopher N. Boddy +1 more
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Recyclable hypervalent-iodine-mediated solid-phase peptide synthesis and cyclic peptide synthesis
Beilstein Journal of Organic Chemistry, 2018 The system of the hypervalent iodine(III) reagent FPID and (4-MeOC6H4)3P was successfully applied to solid-phase peptide synthesis and cyclic peptide synthesis.
Dan Liu, Ya-Li Guo, Jin Qu, Chi Zhang
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Future Medicinal Chemistry, 2015 Many cyclic peptide natural products are larger and structurally more complex than conventional small molecule drugs. Although some molecules in this class are known to possess favorable pharmacokinetic properties, there have been few reports on the ...
Valerie Chen +2 more
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Cyclic Peptide Synthesis with Thioacids
Organic Letters, 2010 International audienceC-Terminal amino acid 9-fluorenylmethylthioesters may be carried through Boc chemistry solution phase peptide synthesis sequences.
Kaname Sasaki +3 more
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