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Development of proteome-derived cyclic peptide libraries via ortho-phthalaldehyde-assisted cyclization [PDF]
iScienceSummary: Cyclic peptides possess unique structural features and binding capabilities that make them attractive scaffolds for molecular recognition. However, strategies for generating functionally diverse libraries directly from natural proteomes remain ...
Ying Wei +6 more
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Cyclic Peptides for the Treatment of Cancers: A Review
Molecules, 2022 Cyclic peptides have been widely reported to have therapeutic abilities in the treatment of cancer. This has been proven through in vitro and in vivo studies against breast, lung, liver, colon, and prostate cancers, among others.
Dalifa Ramadhani +3 more
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Heuristic energy-based cyclic peptide design. [PDF]
PLoS Computational BiologyRational computational design is crucial to the pursuit of novel drugs and therapeutic agents. Meso-scale cyclic peptides, which consist of 7-40 amino acid residues, are of particular interest due to their conformational rigidity, binding specificity ...
Qiyao Zhu +2 more
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Identification of a novel and high-affinity cyclic peptide targeting Keap1 for inflammation treatment by a combined virtual screening strategy [PDF]
Journal of Enzyme Inhibition and Medicinal ChemistryInhibition of the Keap1-Nrf2 protein-protein interaction with cyclic peptides represents an attractive strategy to treat inflammation. However, the cyclic peptides for this inhibition are constrained by their low affinity. In this study, the peptides 1-6
Shenglin Gao +5 more
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Recent Advances in Cyclic Peptide-Based Therapeutic Strategies for Renal Cell Carcinoma: A Focused Review [PDF]
Drug Design, Development and TherapyLiming Sun,1,* Xiaoting Li,2,* Yan Liu,1,* Guangzhen Wu11Department of Urology, the First Affiliated Hospital of Dalian Medical University, Dalian, 116011, People’s Republic of China; 2Department of Radiology, The First Affiliated
Sun L, Li X, Liu Y, Wu G
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Frontiers in Immunology, 2023 IntroductionOur previous research has found that degradation of palmitoyltransferase in tumor cells using a linear peptide PROTAC leads to a significant decrease in PD-L1 expression in tumors.
Yu-Ying Shi +4 more
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Frontiers in Molecular Biosciences, 2023 Genetically-encoded combinatorial peptide libraries are convenient tools to identify peptides to be used as therapeutics, antimicrobials and functional synthetic biology modules. Here, we report the identification and characterization of a cyclic peptide,
Stefano Rosa +11 more
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Efficient 3D conformer generation of cyclic peptides formed by a disulfide bond
Journal of Cheminformatics, 2022 Cyclic peptides formed by disulfide bonds have been one large group of common drug candidates in drug development. Structural information of a peptide is essential to understand its interaction with its target.
Huanyu Tao +4 more
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Current Medicinal Chemistry, 2016 For decades the opioid receptors have been an attractive therapeutic target for the treatment of pain. Since the first discovery of enkephalin, approximately a dozen endogenous opioid peptides have been known to produce opioid activity and analgesia, but their therapeutics have been limited mainly due to low blood brain barrier penetration and poor ...
Michael, Remesic +2 more
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Rapid in silico Design of Potential Cyclic Peptide Binders Targeting Protein-Protein Interfaces
Frontiers in Chemistry, 2020 Rational design of specific inhibitors of protein-protein interactions is desirable for drug design to control cellular signal transduction but also for studying protein-protein interaction networks.
Brianda L. Santini, Martin Zacharias
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