Results 41 to 50 of about 2,011,052 (344)

Evidence for a novel mechanism of antimicrobial action of a cyclic R-,W-rich hexapeptide. [PDF]

PLoS ONE, 2015
The development of antimicrobial peptides as new class of antibiotic agents requires structural characterisation and understanding of their diverse mechanisms of action. As the cyclic hexapeptide cWFW (cyclo(RRRWFW)) does not exert its rapid cell killing
Kathi Scheinpflug, Oxana Krylova, Heike Nikolenko, Charley Thurm, Margitta Dathe   +4 more
doaj   +1 more source

Inhibiting UCH-L5: Rational Design of a Cyclic Ubiquitin-Based Peptide Inhibitor

Frontiers in Molecular Biosciences, 2022
The ubiquitin-proteasome system is an essential regulator of many cellular processes including controlling protein homeostasis. The degradation of proteins by the multi-subunit proteasome complex is tightly regulated through a series of checkpoints ...
Dharjath S. Hameed, Huib Ovaa, Gerbrand J. van der Heden van Noort, Aysegul Sapmaz   +3 more
doaj   +1 more source

Inhibition of HIV budding by a genetically selected cyclic peptide targeting the Gag?TSG101 interaction

, 2008
The egress of HIV particles from virus-infected cells is accomplished by the recruitment of proteins that normally mediate host cell endocytic functions.
Gam, Jongsik, Cohen, Stanley N., Benkovic, Stephen J., Pans, Hui, Tavassoli, Ali, Lu, Quan   +5 more
core   +1 more source

Improving In Vivo Brain Delivery of Monoclonal Antibody Using Novel Cyclic Peptides

Pharmaceutics, 2019
Many proteins can be used to treat brain diseases; however, the presence of the blood−brain barrier (BBB) creates an obstacle to delivering them into the brain.
Kavisha R. Ulapane, Brian M. Kopec, Teruna J. Siahaan   +2 more
doaj   +1 more source

Cyclic AMP signalling in pancreatic islets

, 2010
Cyclic 3'5'AMP (cAMP) is an important physiological amplifier of glucose-induced insulin secretion by the pancreatic islet β-cell, where it is formed by the activity of adenylyl cyclases, which are stimulated by glucose, through elevation in ...
Nigel J. Pyne, Pyne, Nigel J., Brian Furman, Wee Kiat Ong, Furman, Brian L., Ong, Wee Kiat, Ong, W.K., Furman, Brian   +7 more
core   +1 more source

Trypsin inhibition by macrocyclic and open-chain variants of the squash inhibitor MCoTI-II [PDF]

, 2005
MCoTl-I and MCoTl-II from the seeds of Momordica cochinchinensis are inhibitors of trypsin-like proteases and the only known members of the large family of squash inhibitors that are cyclic and contain an additional loop connecting the amino- and the ...
Avrutina, Olga, Gabrijelcic-Geiger, Dusica, Le Nguyen, Dung, Schmoldt, H. U., Sommerhoff, Christian P., Kolmar, Harald, Gabrijelcic-Geiger, D., Le Nguyen, D., Schmoldt, Hans-Ulrich, Diederichsen, Ulf   +9 more
core   +1 more source

Pyridyl Disulfide Reaction Chemistry: An Efficient Strategy toward Redox-Responsive Cyclic Peptide-Polymer Conjugates.

ACS Macro Letters, 2019
Cyclic peptide-polymer conjugates are capable of self-assembling into supramolecular polymeric nanotubes driven by the strong multiple hydrogen bonding interactions between the cyclic peptides.
Qiao Song, Jie Yang, Stephen C. L. Hall, Pratik Gurnani, S. Perrier   +4 more
semanticscholar   +1 more source

A macrolactonization approach to the total synthesis of the antimicrobial cyclic depsipeptide LI-F04a and diastereoisomeric analogues

Beilstein Journal of Organic Chemistry, 2012
The cyclic peptide core of the antifungal and antibiotic cyclic depsipeptide LI-F04a was synthesised by using a modified Yamaguchi macrolactonization approach.
James R. Cochrane, Dong Hee Yoon, Christopher S. P. McErlean, Katrina A. Jolliffe   +3 more
doaj   +1 more source

Structures of the CXCR4 chemokine receptor in complex with small molecule and cyclic peptide antagonists

Science, 2010
Regulating Migration The migration of cells around the body is an important factor in cancer development and the establishment of infection. Movement is induced by small proteins called chemokines, and so for a specific function, migration is controlled ...
Beili Wu, E. Chien, C. Mol, G. Fenalti, Wei Liu, V. Katritch, R. Abagyan, A. Brooun, P. Wells, F. Bi, Damon J. Hamel, P. Kuhn, T. Handel, V. Cherezov, R. Stevens   +14 more
semanticscholar   +1 more source

Presence of short and cyclic peptides in Acacia and Ziziphus honeys may potentiate their medicinal values

Open Chemistry, 2021
Acacia honey is characterized by high nutritional, antioxidant, antibacterial and immuno-modulatory values. This work investigated the presence of short and cyclic peptides in Acacia and Ziziphus honey samples.
ALaerjani Wed Mohammed Ali, Abu-Melha Saraa Abdullah, Khan Khalid Ali, Ghramh Hamed A., Alalmie Ali Yahya A., Alshareef Rahaf Mohammed Hussein, AL-Shehri Badria M., Mohammed Mohammed Elimam Ahamed   +7 more
doaj   +1 more source