Results 31 to 40 of about 2,011,052 (344)

A novel cyclic peptide targeting LAG-3 for cancer immunotherapy by activating antigen-specific CD8+ T cell responses

Acta Pharmaceutica Sinica B, 2020
PD-1 and CTLA-4 antibodies offer great hope for cancer immunotherapy. However, many patients are incapable of responding to PD-1 and CTLA-4 blockade and show low response rates due to insufficient immune activation. The combination of checkpoint blockers
Wenjie Zhai, Xiuman Zhou, Hongfei Wang, Wanqiong Li, Guanyu Chen, Xinghua Sui, Guodong Li, Yuanming Qi, Yanfeng Gao   +8 more
semanticscholar   +1 more source

Association analysis of anti-Epstein-Barr nuclear antigen-1 antibodies, anti-cyclic citrullinated peptide antibodies, the shared epitope and smoking status in Brazilian patients with rheumatoid arthritis

Clinics, 2011
INTRODUCTION: Epstein-Barr virus exposure appears to be an environmental trigger for rheumatoid arthritis that interacts with other risk factors. Relationships among anti-cyclic citrullinated peptide antibodies, the shared epitope, and smoking status ...
Michel Alexandre Yazbek, Silvia de Barros-Mazon, Cláudio Lúcio Rossi, Ana Carolina Londe, Lilian Tereza Lavras Costallat, Manoel Barros Bertolo   +5 more
doaj   +1 more source

Peptide oligomers from ultra-short peptides using sortase

Biochemistry and Biophysics Reports, 2017
Sortase A catalyzed ligation of ultra-short peptides leads to inter/intra-molecular transpeptidation to form either linear or cyclic oligomers dependent upon the peptide length.
Natalya Voloshchuk, Long Chen, Qiang Li, Jun F. Liang   +3 more
doaj   +1 more source

Biomechanical signals and the C-type natriuretic peptide counteract catabolic activities induced by IL-1? in chondrocyte/agarose constructs [PDF]

, 2011
Introduction: The present study examined the effect of C-type natriuretic peptide (CNP) on the anabolic and catabolic activities in chondrocyte/agarose constructs subjected to dynamic compression.
Achan, P., Chowdhury, T.T., Salter, Donald M, Ramachandran, Manoj, Salter, DM, Chowdhury, TT, Ramachandran, M., Ramachandran, M, Dan L Bader, Achan, Prim, Salter, D.M., Tina T Chowdhury, Bader, Dan L, Bader, DL, Prim Achan, Donald M Salter, Chowdhury, Tina T, Bader, Dan L., Manoj Ramachandran, Achan, P   +19 more
core   +1 more source

Methionine epimerization in cyclic peptides

RSC Advances, 2021
One step regioselective methionine epimerization in cyclic peptides followed by selective functionalization leads to chemical novelty.
Pramodkumar D. Jadhav, Jianheng Shen, Peta-Gaye Burnett, Jian Yang, Ramaswami Sammynaiken, Martin J. T. Reaney   +5 more
openaire   +3 more sources

Directed Evolution of Bicyclic Peptides for Therapeutic Application

CHIMIA, 2013
Many naturally occurring cyclic peptides or derivatives thereof are used as therapeutics such as the human hormones vasopressin and oxytocin or the antibiotics vancomycin and daptomycin.
Philippe Diderich, Christian Heinis
doaj   +1 more source

Synthesis of the chlorofusin cyclic peptide [PDF]

Tetrahedron, 2009
An efficient and convergent solution-phase synthesis of the cyclic peptide of the natural product chlorofusin, a reported inhibitor of the MDM2-p53 interaction, is detailed.
Sang Yeul, Lee, Dale L, Boger
openaire   +2 more sources

Discovery and Characteristics of a Novel Antitumor Cyclopeptide Derived from Shark

Bioengineering, 2023
Peptides pose a challenge in drug development due to their short half-lives in vivo. In this study, we conducted in vitro degradation experiments on SAIF, which is a shark-derived peptide that we previously studied.
Fu Li, Minghua Lei, Junye Xie, Shujun Guo, Weicai Li, Xiujuan Ren, Teng Wang, Songxiong Lin, Qiuling Xie, Xiaojia Chen   +9 more
doaj   +1 more source

A Genetically Encoded, Phage-Displayed Cyclic Peptide Library

Angewandte Chemie, 2019
Superior to linear peptides in biological activities, cyclic peptides are considered to have great potentials used as therapeutic agents. In order to identify cyclic peptide ligands for therapeutic targets, selection from phage-displayed peptide ...
Xiaosha Wang, P. Chen, J. T. Hampton, Jeffery M. Tharp, C. A. Reed, Sukant Das, Duen-Shian Wang, Hamed S. Hayatshahi, Yang Shen, Jin Liu, Wenshe Ray Liu   +10 more
semanticscholar   +1 more source

Binding Interactions of Peptide Aptamers

Molecules, 2020
Peptide aptamers are short amino acid chains that are capable of binding specifically to ligands in the same way as their much larger counterparts, antibodies. Ligands of therapeutic interest that can be targeted are other peptide chains or loops located
Roger R. C. New, Tam T. T. Bui, Michal Bogus   +2 more
doaj   +1 more source