Results 31 to 40 of about 295,340 (305)
Sweetening Cyclic Peptide Libraries [PDF]
ChemInform, 2004 AbstractFor Abstract see ChemInform Abstract in Full Text.
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Cyclic Peptides for Drug Development
Angewandte Chemie International Edition, 2023 AbstractCyclic peptides are fascinating molecules abundantly found in nature and exploited as molecular format for drug development as well as other applications, ranging from research tools to food additives. Advances in peptide technologies made over many years through improved methods for synthesis and drug development have resulted in a steady ...
Ji, Xinjian +2 more
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Binding Interactions of Peptide Aptamers
Molecules, 2020 Peptide aptamers are short amino acid chains that are capable of binding specifically to ligands in the same way as their much larger counterparts, antibodies. Ligands of therapeutic interest that can be targeted are other peptide chains or loops located
Roger R. C. New +2 more
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Evidence for a novel mechanism of antimicrobial action of a cyclic R-,W-rich hexapeptide. [PDF]
PLoS ONE, 2015 The development of antimicrobial peptides as new class of antibiotic agents requires structural characterisation and understanding of their diverse mechanisms of action. As the cyclic hexapeptide cWFW (cyclo(RRRWFW)) does not exert its rapid cell killing
Kathi Scheinpflug +4 more
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Discovery and Characteristics of a Novel Antitumor Cyclopeptide Derived from Shark
Bioengineering, 2023 Peptides pose a challenge in drug development due to their short half-lives in vivo. In this study, we conducted in vitro degradation experiments on SAIF, which is a shark-derived peptide that we previously studied.
Fu Li +9 more
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Natriuretic peptide receptors regulate cytoprotective effects in a human ex vivo 3D/bioreactor model [PDF]
, 2013 © 2013 Peake et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and ...
Achan, P +8 more
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Improving In Vivo Brain Delivery of Monoclonal Antibody Using Novel Cyclic Peptides
Pharmaceutics, 2019 Many proteins can be used to treat brain diseases; however, the presence of the blood−brain barrier (BBB) creates an obstacle to delivering them into the brain.
Kavisha R. Ulapane +2 more
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Beilstein Journal of Organic Chemistry, 2012 The cyclic peptide core of the antifungal and antibiotic cyclic depsipeptide LI-F04a was synthesised by using a modified Yamaguchi macrolactonization approach.
James R. Cochrane +3 more
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A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells [PDF]
, 2013 Hypoxia inducible factor-1 (HIF-1) is a heterodimeric transcription factor that acts as the master regulator of cellular response to reduced oxygen levels, thus playing a key role in the adaptation, survival and progression of tumors.
Court, William +11 more
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Methionine epimerization in cyclic peptides
RSC Advances, 2021 One step regioselective methionine epimerization in cyclic peptides followed by selective functionalization leads to chemical novelty.
Pramodkumar D. Jadhav +5 more
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