Results 21 to 30 of about 2,011,052 (344)

Cyclization and Docking Protocol for Cyclic Peptide–Protein Modeling Using HADDOCK2.4

Journal of Chemical Theory and Computation, 2022
An emerging class of therapeutic molecules are cyclic peptides with over 40 cyclic peptide drugs currently in clinical use. Their mode of action is, however, not fully understood, impeding rational drug design.
Vicky Charitou, Siri C. van Keulen, A. Bonvin   +2 more
semanticscholar   +1 more source

Screening technology of cyclic peptide library based on gene encoding

Medicine in Drug Discovery, 2022
As a powerful tool for the discovery of peptide compounds, high-throughput library screening technology can also perform multitarget screening with high chemical diversity as a condition, which accelerates the process of exploring high-affinity peptide ...
Yangqiang Chen, Chonggang Duan, Kai Chen, Shumeng Sun, Daizhou Zhang, Xiangjing Meng   +5 more
doaj   +1 more source

Research Progress on Cyclic-Peptide Functionalized Nanoparticles for Tumor-Penetrating Delivery [PDF]

International Journal of Nanomedicine
Chenkai Wang,1,2 Zefan Shen,1,2 Yiyang Chen,1,2 Yifan Wang,2 Xuanyi Zhou,2 Xinyi Chen,1 Yuhang Li,2 Pu Zhang,2 Qi Zhang2 1The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, People’s Republic of China; 2Urology ...
Wang C, Shen Z, Chen Y, Wang Y, Zhou X, Chen X, Li Y, Zhang P, Zhang Q   +8 more
doaj   +2 more sources

Anion recognition by cyclic peptides [PDF]

Chemical Communications, 2015
Cyclic peptides provide excellent scaffolds for anion recognition and improved binding affinity and selectivity has been achieved through peptide backbone rigidification and the introduction of side chains bearing anion recognition groups.
Elmes, Robert B. P., Jolliffe, Katrina A.   +1 more
openaire   +5 more sources

Plant derived cyclic peptides [PDF]

Biochemical Society Transactions, 2021
Cyclic peptides are widespread throughout the plant kingdom, and display diverse sequences, structures and bioactivities. The potential applications attributed to these peptides and their unusual biosynthesis has captivated the attention of researchers for many years.
Norelle L. Daly, David T. Wilson
openaire   +3 more sources

A Rapid and Efficient Building Block Approach for Click Cyclization of Peptoids

Frontiers in Chemistry, 2020
Cyclic peptide-peptoid hybrids possess improved stability and selectivity over linear peptides and are thus better drug candidates. However, their synthesis is far from trivial and is usually difficult to automate.
Mamidi Samarasimhareddy, Mai Shamir, Deborah E. Shalev, Deborah E. Shalev, Mattan Hurevich, Assaf Friedler   +5 more
doaj   +1 more source

Click Conjugation of Boron Dipyrromethene (BODIPY) Fluorophores to EGFR-Targeting Linear and Cyclic Peptides

Molecules, 2021
Through a simple 1,3-cycloaddition reaction, three BODIPY-peptide conjugates that target the extracellular domain of the epidermal growth factor receptor (EGFR) were prepared and their ability for binding to EGFR was investigated.
Tyrslai M. Williams, Nichole E. M. Kaufman, Zehua Zhou, Sitanshu S. Singh, Seetharama D. Jois, Maria da Graça H. Vicente   +5 more
doaj   +1 more source

Cyclic Peptides for the Treatment of Cancers: A Review

Molecules, 2022
Cyclic peptides have been widely reported to have therapeutic abilities in the treatment of cancer. This has been proven through in vitro and in vivo studies against breast, lung, liver, colon, and prostate cancers, among others.
Dalifa Ramadhani, Rani Maharani, Amirah Mohd Gazzali, Muchtaridi Muchtaridi   +3 more
doaj   +1 more source

GTP-State-Selective Cyclic Peptide Ligands of K-Ras(G12D) Block Its Interaction with Raf

ACS Central Science, 2020
We report the identification of three cyclic peptide ligands of K-Ras(G12D) using an integrated in vitro translation–mRNA display selection platform. These cyclic peptides show preferential binding to the GTP-bound state of K-Ras(G12D) over the GDP-bound
Ziyang Zhang, R. Gao, Q. Hu, H. Peacock, D. M. Peacock, Shizhong A. Dai, K. Shokat, H. Suga, −. D.MatthewPeacock   +8 more
semanticscholar   +1 more source

Natriuretic peptide receptors regulate cytoprotective effects in an ex vivo human 3D/bioreactor model [PDF]

, 2013
IntroductionThe present study examined the effect of C-type natriuretic peptide (CNP) and biomechanical signals on anabolic and catabolic activities in chondrocyte/agarose constructs.MethodsNatriuretic peptide (Npr) 2 and 3 expression were compared in ...
Salter, Donald M, Salter, Donald M., Ramachandran, Manoj, Adrian J Hobbs, Hobbs, Adrian J., Ramachandran, M, Moyes, AJ, Amie J Moyes, Peake, Nicholas, Bader, Dan L, Bader, DL, Chowdhury, Tina T., Donald M Salter, Pramod Achan, Bader, Dan L., Peake, N, Su, N, Achan, P, Hobbs, AJ, Salter, DM, Nyan Su, Achan, Pramod, Nicholas Peake, Chowdhury, TT, Moyes, Amie J., Dan L Bader, Tina T Chowdhury, Su, Nyan, Chowdhury, Tina T, Hobbs, Adrian J, Moyes, Amie J, Manoj Ramachandran   +31 more
core   +1 more source