Results 61 to 70 of about 295,340 (305)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Computational Design and Optimization of Peptide Inhibitors for SIRT2

Pharmaceuticals
Sirtuin 2 (SIRT2), an NAD+-dependent deacetylase, is crucial for regulating vital physiological processes, including aging, DNA repair, and cell cycle progression.
Heba A. Alkhatabi, Fatmah M. A. Naemi, Reem Alsolami, Hisham N. Alatyb   +3 more
doaj   +1 more source

Prevalence of antibodies against a cyclic peptide mimicking the FG loop of the human papillomavirus type 16 capsid among Tunisian women

Journal of Translational Medicine, 2020
Background In the past decade, cervical cancer has gone from being the second to the fourth most common cancer in women worldwide, but remains the second most common in developing countries. This cancer is most commonly caused by high-risk types of human
Elham Hassen, Devendra Bansal, Randa Ghdira, Anouar Chaieb, Hedi Khairi, Abdelfattah Zakhama, Sami Remadi, Johan Hoebeke, Ali A. Sultan, Lotfi Chouchane   +9 more
doaj   +1 more source

Identification and Pharmacological Characterization of a Low-Liability Antinociceptive Bifunctional MOR/DOR Cyclic Peptide

Molecules, 2023
Peptide-based opioid ligands are important candidates for the development of novel, safer, and more effective analgesics to treat pain. To develop peptide-based safer analgesics, we synthesized a mixture-based cyclic pentapeptide library containing a ...
Yangmei Li, Shainnel O. Eans, Michelle Ganno-Sherwood, Abbe Eliasof, Richard A. Houghten, Jay P. McLaughlin   +5 more
doaj   +1 more source

Novel pH-Sensitive Cyclic Peptides [PDF]

Scientific Reports, 2016
AbstractA series of cyclic peptides containing a number of tryptophan (W) and glutamic acid (E) residues were synthesized and evaluated as pH-sensitive agents for targeting of acidic tissue and pH-dependent cytoplasmic delivery of molecules. Biophysical studies revealed the molecular mechanism of peptides action and localization within the lipid ...
Weerakkody, Dhammika, Moshnikova, Anna, El-Sayed, Naglaa Salem, Adochite, Ramona-Cosima, Slaybaugh, Gregory, Golijanin, Jovana, Tiwari, Rakesh, Andreev, Oleg A., Parang, Keykavous, Reshetnyak, Yana K.   +9 more
openaire   +3 more sources

Improving binding affinity through cyclization [PDF]

, 2017
Cancer chemotherapy results in systematic damage as the drugs used are also toxic to benign tissue. Sensitizing a cancer cell to therapy by interfering with the DNA repair mechanisms would decrease overall toxicity, as the necessary dosage of ...
Abrigo, Nicolas, Newcomb, Kaylee M
core   +1 more source

Pass-back chain extension expands multimodular assembly line biosynthesis. [PDF]

, 2020
Modular nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS) enzymatic assembly lines are large and dynamic protein machines that generally effect a linear sequence of catalytic cycles.
Huan, Tao, Moore, Bradley S, Ross, Avena C, Tang, Xiaoyu, Tang, Xiaoyu, Zhang, Jia Jia   +5 more
core  

Truncated and Helix-Constrained Peptides with High Affinity and Specificity for the cFos Coiled-Coil of AP-1 [PDF]

, 2013
Protein-based therapeutics feature large interacting surfaces. Protein folding endows structural stability to localised surface epitopes, imparting high affinity and target specificity upon interactions with binding partners.
A Patgiri, B Ibarra-Molero, BN Bullock, BR Brooks, BW Ozanne, CN Pace, D Aud, D Derossi, D Krylov, D Seebach, D Wang, D Wang, D Wang, D Wang, DA Guarracino, David P. Fairlie, DH Appella, DP Fairlie, DP Fairlie, E Vives, EF Wagner, EK O’Shea, EK O’Shea, EK O’Shea, F Bernal, F Bernal, GH Bird, GH Bird, Gloria Ruiz-Gómez, Huy N. Hoang, J Liu, JD Tyndall, JK Judice, JM Dixon, JM Mason, JM Mason, JM Mason, JM Mason, JN Glover, Jody M. Mason, Jose M. Sanchez-Ruiz, LD Walensky, LD Walensky, LK Henchey, LM Johnson, NE Shepherd, NE Shepherd, NE Shepherd, P Lavigne, PS Kutchukian, R Eferl, R Zenz, RE Moellering, RN Chapman, RO Crooks, RS Harrison, S Baek, SM Fuchs, T Wiseman, TA Libermann, Tara Rao, Timothy A. Hill, YW Kim, YW Kim   +63 more
core   +3 more sources

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Software-aided approach to investigate peptide structure and metabolic susceptibility of amide bonds in peptide drugs based on high resolution mass spectrometry. [PDF]

PLoS ONE, 2017
Interest in using peptide molecules as therapeutic agents due to high selectivity and efficacy is increasing within the pharmaceutical industry. However, most peptide-derived drugs cannot be administered orally because of low bioavailability and ...
Tatiana Radchenko, Andreas Brink, Yves Siegrist, Christopher Kochansky, Alison Bateman, Fabien Fontaine, Luca Morettoni, Ismael Zamora   +7 more
doaj   +1 more source